Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes
Abstract In this study, we planned to investigate the clinical course of patients with breast cancer with oligometastatic bone disease (OMBD). The patients were grouped according to the characteristics and the sites of metastases. Group I included 928 patients without metastasis. Group II, the OMBD...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-99726-7 |
| _version_ | 1818897190240649216 |
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| author | Baha Zengel Mustafa Kilic Funda Tasli Cenk Simsek Murat Karatas Ozlem Ozdemir Demet Cavdar Raika Durusoy Kadir Koray Bas Adam Uslu |
| author_facet | Baha Zengel Mustafa Kilic Funda Tasli Cenk Simsek Murat Karatas Ozlem Ozdemir Demet Cavdar Raika Durusoy Kadir Koray Bas Adam Uslu |
| author_sort | Baha Zengel |
| collection | DOAJ |
| description | Abstract In this study, we planned to investigate the clinical course of patients with breast cancer with oligometastatic bone disease (OMBD). The patients were grouped according to the characteristics and the sites of metastases. Group I included 928 patients without metastasis. Group II, the OMBD group, included 68 patients. Group III, the widespread metastasis group, comprised 185 patients with multiple bone metastases and/or solid organ metastases. The mean overall survival of the groups was 16.7 ± 0.3 years in group 1, and 7.8 ± 0.8 and 5.9 ± 0.4 years in groups 2 and 3, respectively (p < 0.001 for the comparison of all three groups together; p < 0.001 for group 1 vs. 2 and 3) and (p = 0.037 for group 2 vs. group 3). In the subgroup survival analysis of patients in group 2 (OMBD), the mean and median survival was 5.5 ± 0.8 and 4.0 ± 0.8 years vs. 9.2 ± 0.98 and 9.0 ± 1.05 years in patients with more than one bone metastasis and single bone metastasis, respectively (p = 0.019). OMBD seems to be a different disease than breast cancer with isolated bone metastases. The high risk of developing OMBD, especially following locoregional recurrence, increases the importance of locoregional therapy in large T and N stage tumors. |
| first_indexed | 2024-12-19T19:12:14Z |
| format | Article |
| id | doaj.art-b6c8461397374162ade8005d10afb2f9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T19:12:14Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b6c8461397374162ade8005d10afb2f92022-12-21T20:09:14ZengNature PortfolioScientific Reports2045-23222021-10-0111111210.1038/s41598-021-99726-7Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomesBaha Zengel0Mustafa Kilic1Funda Tasli2Cenk Simsek3Murat Karatas4Ozlem Ozdemir5Demet Cavdar6Raika Durusoy7Kadir Koray Bas8Adam Uslu9Department of General Surgery, Izmir Bozyaka Health Practice and Research Center, University of Health Sciences TurkeyDepartment of General Surgery, Izmir Bozyaka Health Practice and Research Center, University of Health Sciences TurkeyDepartment of Pathology, Izmir Bozyaka Health Practice and Research Center, University of Health Sciences TurkeyDepartment of General Surgery, Izmir Bozyaka Health Practice and Research Center, University of Health Sciences TurkeyDepartment of General Surgery, Izmir Bozyaka Health Practice and Research Center, University of Health Sciences TurkeyDepartment of Medical Oncology, Izmir Bozyaka Health Practice and Research Center, University of Health Sciences TurkeyDepartment of Pathology, Izmir Bozyaka Health Practice and Research Center, University of Health Sciences TurkeyDepartment of Public Health, Medical Faculty, Ege UniversityDepartment of General Surgery, Izmir Bozyaka Health Practice and Research Center, University of Health Sciences TurkeyDepartment of General Surgery, Izmir Bozyaka Health Practice and Research Center, University of Health Sciences TurkeyAbstract In this study, we planned to investigate the clinical course of patients with breast cancer with oligometastatic bone disease (OMBD). The patients were grouped according to the characteristics and the sites of metastases. Group I included 928 patients without metastasis. Group II, the OMBD group, included 68 patients. Group III, the widespread metastasis group, comprised 185 patients with multiple bone metastases and/or solid organ metastases. The mean overall survival of the groups was 16.7 ± 0.3 years in group 1, and 7.8 ± 0.8 and 5.9 ± 0.4 years in groups 2 and 3, respectively (p < 0.001 for the comparison of all three groups together; p < 0.001 for group 1 vs. 2 and 3) and (p = 0.037 for group 2 vs. group 3). In the subgroup survival analysis of patients in group 2 (OMBD), the mean and median survival was 5.5 ± 0.8 and 4.0 ± 0.8 years vs. 9.2 ± 0.98 and 9.0 ± 1.05 years in patients with more than one bone metastasis and single bone metastasis, respectively (p = 0.019). OMBD seems to be a different disease than breast cancer with isolated bone metastases. The high risk of developing OMBD, especially following locoregional recurrence, increases the importance of locoregional therapy in large T and N stage tumors.https://doi.org/10.1038/s41598-021-99726-7 |
| spellingShingle | Baha Zengel Mustafa Kilic Funda Tasli Cenk Simsek Murat Karatas Ozlem Ozdemir Demet Cavdar Raika Durusoy Kadir Koray Bas Adam Uslu Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes Scientific Reports |
| title | Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes |
| title_full | Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes |
| title_fullStr | Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes |
| title_full_unstemmed | Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes |
| title_short | Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes |
| title_sort | breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes |
| url | https://doi.org/10.1038/s41598-021-99726-7 |
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