Tissue Augmentation by White Blood Cell-Containing Platelet-Rich Plasma
Platelet-rich plasma (PRP) is a matrix of fibrin and platelets that releases cytokines that are important in wound healing. PRP is produced from the patient's blood and therefore has less risk of allergic reaction and infection. We have obtained PRP with an enhanced white blood cell component (...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-03-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/096368911X605538 |
| _version_ | 1819210399104368640 |
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| author | Takeshi Kawazoe M.D., Ph.D. Hak Hee Kim |
| author_facet | Takeshi Kawazoe M.D., Ph.D. Hak Hee Kim |
| author_sort | Takeshi Kawazoe M.D., Ph.D. |
| collection | DOAJ |
| description | Platelet-rich plasma (PRP) is a matrix of fibrin and platelets that releases cytokines that are important in wound healing. PRP is produced from the patient's blood and therefore has less risk of allergic reaction and infection. We have obtained PRP with an enhanced white blood cell component (W-PRP) by optimizing the centrifugal separation of PRP from plasma. Here we show that injection of W-PRP into the auricle of nude mice gave greater tissue augmentation compared to PRP. Further augmentation occurred when bFGF was added to W-PRP, and there was a significant increase in the number of α-smooth muscle actin-positive cells in mice treated with W-PRP+bFGF. Our results suggest that W-PRP may have value in cosmetic surgery aimed at rejuvenation of wrinkled and sagging skin. W-PRP injection constitutes a new concept in cell transplantation, in which cells required for tissue regeneration are induced by cytokines released from the transplanted cells. |
| first_indexed | 2024-12-23T06:10:33Z |
| format | Article |
| id | doaj.art-b6cb505bff81488e86a3579190d6524b |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-23T06:10:33Z |
| publishDate | 2012-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-b6cb505bff81488e86a3579190d6524b2022-12-21T17:57:27ZengSAGE PublishingCell Transplantation0963-68971555-38922012-03-012110.3727/096368911X605538Tissue Augmentation by White Blood Cell-Containing Platelet-Rich PlasmaTakeshi Kawazoe M.D., Ph.D.0Hak Hee Kim1 Department of Plastic Reconstructive and Aesthetic Surgery, Kijunkai, Yoshikawa Hospital, Kyoto, Japan Institute for Frontier Medical Science, Kyoto University, Kyoto, JapanPlatelet-rich plasma (PRP) is a matrix of fibrin and platelets that releases cytokines that are important in wound healing. PRP is produced from the patient's blood and therefore has less risk of allergic reaction and infection. We have obtained PRP with an enhanced white blood cell component (W-PRP) by optimizing the centrifugal separation of PRP from plasma. Here we show that injection of W-PRP into the auricle of nude mice gave greater tissue augmentation compared to PRP. Further augmentation occurred when bFGF was added to W-PRP, and there was a significant increase in the number of α-smooth muscle actin-positive cells in mice treated with W-PRP+bFGF. Our results suggest that W-PRP may have value in cosmetic surgery aimed at rejuvenation of wrinkled and sagging skin. W-PRP injection constitutes a new concept in cell transplantation, in which cells required for tissue regeneration are induced by cytokines released from the transplanted cells.https://doi.org/10.3727/096368911X605538 |
| spellingShingle | Takeshi Kawazoe M.D., Ph.D. Hak Hee Kim Tissue Augmentation by White Blood Cell-Containing Platelet-Rich Plasma Cell Transplantation |
| title | Tissue Augmentation by White Blood Cell-Containing Platelet-Rich Plasma |
| title_full | Tissue Augmentation by White Blood Cell-Containing Platelet-Rich Plasma |
| title_fullStr | Tissue Augmentation by White Blood Cell-Containing Platelet-Rich Plasma |
| title_full_unstemmed | Tissue Augmentation by White Blood Cell-Containing Platelet-Rich Plasma |
| title_short | Tissue Augmentation by White Blood Cell-Containing Platelet-Rich Plasma |
| title_sort | tissue augmentation by white blood cell containing platelet rich plasma |
| url | https://doi.org/10.3727/096368911X605538 |
| work_keys_str_mv | AT takeshikawazoemdphd tissueaugmentationbywhitebloodcellcontainingplateletrichplasma AT hakheekim tissueaugmentationbywhitebloodcellcontainingplateletrichplasma |