Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice
Loss of function of the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2) causes the progressive neurological disorder Rett syndrome (RTT). Conversely, duplication or triplication of Xq28 causes an equally wide-ranging progressive neurological disorder, MECP2 duplication syndrome, whose fe...
Main Authors: | Laura Dean Heckman, Maria H Chahrour, Huda Y Zoghbi |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-06-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/02676 |
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