Synthesis, characterization and biological activity of zinc complexes of ethylenediamine and its derivatives
Inorganic Complexes are widely used in pharmaceutical industry. Especially chelating complexes are used as the scavengers of heavy metal ions. This present study is aimed to synthesis ethylenediamine and its derivative Zn (II) complexes, and identifies the biological efficiency of the complexes. The...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Chemical Physics Impact |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667022423000889 |
| Summary: | Inorganic Complexes are widely used in pharmaceutical industry. Especially chelating complexes are used as the scavengers of heavy metal ions. This present study is aimed to synthesis ethylenediamine and its derivative Zn (II) complexes, and identifies the biological efficiency of the complexes. The 1H NMR spectra of ligands and Zn complexes are confirming the complexation. Downfield shifts of complexes further support the complexation. All the complexes are well crystalline and the average particle size is 80. The calculated percentage of an element in all the complexes is well agreed with the percentage of elements obtained from the CHNS analyzer. Applications of the complexes are studied by its Invitro Anti-diabetic activity. [Zn(pren)2]2+complex exhibits greater percentage inhibition (63.57%). The homo catenation of the ligand is response to increase the drug efficiency. |
|---|---|
| ISSN: | 2667-0224 |