Synthesis, characterization and biological activity of zinc complexes of ethylenediamine and its derivatives
Inorganic Complexes are widely used in pharmaceutical industry. Especially chelating complexes are used as the scavengers of heavy metal ions. This present study is aimed to synthesis ethylenediamine and its derivative Zn (II) complexes, and identifies the biological efficiency of the complexes. The...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Chemical Physics Impact |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667022423000889 |
| _version_ | 1797400886192898048 |
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| author | M. Jaya Brabha M. Anitha Malbi |
| author_facet | M. Jaya Brabha M. Anitha Malbi |
| author_sort | M. Jaya Brabha |
| collection | DOAJ |
| description | Inorganic Complexes are widely used in pharmaceutical industry. Especially chelating complexes are used as the scavengers of heavy metal ions. This present study is aimed to synthesis ethylenediamine and its derivative Zn (II) complexes, and identifies the biological efficiency of the complexes. The 1H NMR spectra of ligands and Zn complexes are confirming the complexation. Downfield shifts of complexes further support the complexation. All the complexes are well crystalline and the average particle size is 80. The calculated percentage of an element in all the complexes is well agreed with the percentage of elements obtained from the CHNS analyzer. Applications of the complexes are studied by its Invitro Anti-diabetic activity. [Zn(pren)2]2+complex exhibits greater percentage inhibition (63.57%). The homo catenation of the ligand is response to increase the drug efficiency. |
| first_indexed | 2024-03-09T02:02:06Z |
| format | Article |
| id | doaj.art-b6ccdc2b4ddc4bc5979ec600e9edf778 |
| institution | Directory Open Access Journal |
| issn | 2667-0224 |
| language | English |
| last_indexed | 2024-03-09T02:02:06Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Physics Impact |
| spelling | doaj.art-b6ccdc2b4ddc4bc5979ec600e9edf7782023-12-08T04:46:21ZengElsevierChemical Physics Impact2667-02242023-12-017100248Synthesis, characterization and biological activity of zinc complexes of ethylenediamine and its derivativesM. Jaya Brabha0M. Anitha Malbi1Department of Chemistry, Holy Cross College, Nagercoil, Affiliated to Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, IndiaCorresponding author.; Department of Chemistry, Holy Cross College, Nagercoil, Affiliated to Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, IndiaInorganic Complexes are widely used in pharmaceutical industry. Especially chelating complexes are used as the scavengers of heavy metal ions. This present study is aimed to synthesis ethylenediamine and its derivative Zn (II) complexes, and identifies the biological efficiency of the complexes. The 1H NMR spectra of ligands and Zn complexes are confirming the complexation. Downfield shifts of complexes further support the complexation. All the complexes are well crystalline and the average particle size is 80. The calculated percentage of an element in all the complexes is well agreed with the percentage of elements obtained from the CHNS analyzer. Applications of the complexes are studied by its Invitro Anti-diabetic activity. [Zn(pren)2]2+complex exhibits greater percentage inhibition (63.57%). The homo catenation of the ligand is response to increase the drug efficiency.http://www.sciencedirect.com/science/article/pii/S2667022423000889Anti-diabeticAlpha-glucosidaseAlpha- amylase1H NMR and CHNS |
| spellingShingle | M. Jaya Brabha M. Anitha Malbi Synthesis, characterization and biological activity of zinc complexes of ethylenediamine and its derivatives Chemical Physics Impact Anti-diabetic Alpha-glucosidase Alpha- amylase 1H NMR and CHNS |
| title | Synthesis, characterization and biological activity of zinc complexes of ethylenediamine and its derivatives |
| title_full | Synthesis, characterization and biological activity of zinc complexes of ethylenediamine and its derivatives |
| title_fullStr | Synthesis, characterization and biological activity of zinc complexes of ethylenediamine and its derivatives |
| title_full_unstemmed | Synthesis, characterization and biological activity of zinc complexes of ethylenediamine and its derivatives |
| title_short | Synthesis, characterization and biological activity of zinc complexes of ethylenediamine and its derivatives |
| title_sort | synthesis characterization and biological activity of zinc complexes of ethylenediamine and its derivatives |
| topic | Anti-diabetic Alpha-glucosidase Alpha- amylase 1H NMR and CHNS |
| url | http://www.sciencedirect.com/science/article/pii/S2667022423000889 |
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