Mitophagy—A New Target of Bone Disease
Bone diseases are usually caused by abnormal metabolism and death of cells in bones, including osteoblasts, osteoclasts, osteocytes, chondrocytes, and bone marrow mesenchymal stem cells. Mitochondrial dysfunction, as an important cause of abnormal cell metabolism, is widely involved in the occurrenc...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/10/1420 |
| _version_ | 1797474951401308160 |
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| author | Zhipeng Zeng Xuchang Zhou Yan Wang Hong Cao Jianmin Guo Ping Wang Yajing Yang Yan Wang |
| author_facet | Zhipeng Zeng Xuchang Zhou Yan Wang Hong Cao Jianmin Guo Ping Wang Yajing Yang Yan Wang |
| author_sort | Zhipeng Zeng |
| collection | DOAJ |
| description | Bone diseases are usually caused by abnormal metabolism and death of cells in bones, including osteoblasts, osteoclasts, osteocytes, chondrocytes, and bone marrow mesenchymal stem cells. Mitochondrial dysfunction, as an important cause of abnormal cell metabolism, is widely involved in the occurrence and progression of multiple bone diseases, including osteoarthritis, intervertebral disc degeneration, osteoporosis, and osteosarcoma. As selective mitochondrial autophagy for damaged or dysfunctional mitochondria, mitophagy is closely related to mitochondrial quality control and homeostasis. Accumulating evidence suggests that mitophagy plays an important regulatory role in bone disease, indicating that regulating the level of mitophagy may be a new strategy for bone-related diseases. Therefore, by reviewing the relevant literature in recent years, this paper reviews the potential mechanism of mitophagy in bone-related diseases, including osteoarthritis, intervertebral disc degeneration, osteoporosis, and osteosarcoma, to provide a theoretical basis for the related research of mitophagy in bone diseases. |
| first_indexed | 2024-03-09T20:37:16Z |
| format | Article |
| id | doaj.art-b6cd22baff024f2b96e7bca186bbdef5 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:37:16Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-b6cd22baff024f2b96e7bca186bbdef52023-11-23T23:08:23ZengMDPI AGBiomolecules2218-273X2022-10-011210142010.3390/biom12101420Mitophagy—A New Target of Bone DiseaseZhipeng Zeng0Xuchang Zhou1Yan Wang2Hong Cao3Jianmin Guo4Ping Wang5Yajing Yang6Yan Wang7School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaDepartment of Rehabilitation, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Physical Education and Sports Science, Lingnan Normal University, Zhanjiang 524048, ChinaCancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, ChinaSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaBone diseases are usually caused by abnormal metabolism and death of cells in bones, including osteoblasts, osteoclasts, osteocytes, chondrocytes, and bone marrow mesenchymal stem cells. Mitochondrial dysfunction, as an important cause of abnormal cell metabolism, is widely involved in the occurrence and progression of multiple bone diseases, including osteoarthritis, intervertebral disc degeneration, osteoporosis, and osteosarcoma. As selective mitochondrial autophagy for damaged or dysfunctional mitochondria, mitophagy is closely related to mitochondrial quality control and homeostasis. Accumulating evidence suggests that mitophagy plays an important regulatory role in bone disease, indicating that regulating the level of mitophagy may be a new strategy for bone-related diseases. Therefore, by reviewing the relevant literature in recent years, this paper reviews the potential mechanism of mitophagy in bone-related diseases, including osteoarthritis, intervertebral disc degeneration, osteoporosis, and osteosarcoma, to provide a theoretical basis for the related research of mitophagy in bone diseases.https://www.mdpi.com/2218-273X/12/10/1420mitophagyosteoarthritisintervertebral disc degenerationosteoporosisosteosarcoma |
| spellingShingle | Zhipeng Zeng Xuchang Zhou Yan Wang Hong Cao Jianmin Guo Ping Wang Yajing Yang Yan Wang Mitophagy—A New Target of Bone Disease Biomolecules mitophagy osteoarthritis intervertebral disc degeneration osteoporosis osteosarcoma |
| title | Mitophagy—A New Target of Bone Disease |
| title_full | Mitophagy—A New Target of Bone Disease |
| title_fullStr | Mitophagy—A New Target of Bone Disease |
| title_full_unstemmed | Mitophagy—A New Target of Bone Disease |
| title_short | Mitophagy—A New Target of Bone Disease |
| title_sort | mitophagy a new target of bone disease |
| topic | mitophagy osteoarthritis intervertebral disc degeneration osteoporosis osteosarcoma |
| url | https://www.mdpi.com/2218-273X/12/10/1420 |
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