Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice.
Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregnancy, folic acid (FA) supplementation may reduce the risk of abnormal pregnancy outcomes. Intriguingly, FA may have a beneficial effect on the adverse pregnancy outcomes assoc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-05-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1008521 |
| _version_ | 1819133150717018112 |
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| author | Yogy Simanjuntak Hui-Ying Ko Yi-Ling Lee Guann-Yi Yu Yi-Ling Lin |
| author_facet | Yogy Simanjuntak Hui-Ying Ko Yi-Ling Lee Guann-Yi Yu Yi-Ling Lin |
| author_sort | Yogy Simanjuntak |
| collection | DOAJ |
| description | Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregnancy, folic acid (FA) supplementation may reduce the risk of abnormal pregnancy outcomes. Intriguingly, FA may have a beneficial effect on the adverse pregnancy outcomes associated with ZIKV infection. Here, we show that FA inhibits ZIKV replication in human umbilical vein endothelial cells (HUVECs) and a cell culture model of blood-placental barrier (BPB). The inhibitory effect of FA against ZIKV infection is associated with FRα-AMPK signaling. Furthermore, treatment with FA reduces pathological features in the placenta, number of fetal resorptions, and stillbirths in two mouse models of in utero ZIKV transmission. Mice with FA treatment showed lower viral burden and better prognostic profiles in the placenta including reduced inflammatory response, and enhanced integrity of BPB. Overall, our findings suggest the preventive role of FA supplementation in ZIKV-associated abnormal pregnancy and warrant nutritional surveillance to evaluate maternal FA status in areas with active ZIKV transmission. |
| first_indexed | 2024-12-22T09:42:43Z |
| format | Article |
| id | doaj.art-b6cf19edc59341149c7bdecf545cbd07 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-22T09:42:43Z |
| publishDate | 2020-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-b6cf19edc59341149c7bdecf545cbd072022-12-21T18:30:38ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742020-05-01165e100852110.1371/journal.ppat.1008521Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice.Yogy SimanjuntakHui-Ying KoYi-Ling LeeGuann-Yi YuYi-Ling LinZika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregnancy, folic acid (FA) supplementation may reduce the risk of abnormal pregnancy outcomes. Intriguingly, FA may have a beneficial effect on the adverse pregnancy outcomes associated with ZIKV infection. Here, we show that FA inhibits ZIKV replication in human umbilical vein endothelial cells (HUVECs) and a cell culture model of blood-placental barrier (BPB). The inhibitory effect of FA against ZIKV infection is associated with FRα-AMPK signaling. Furthermore, treatment with FA reduces pathological features in the placenta, number of fetal resorptions, and stillbirths in two mouse models of in utero ZIKV transmission. Mice with FA treatment showed lower viral burden and better prognostic profiles in the placenta including reduced inflammatory response, and enhanced integrity of BPB. Overall, our findings suggest the preventive role of FA supplementation in ZIKV-associated abnormal pregnancy and warrant nutritional surveillance to evaluate maternal FA status in areas with active ZIKV transmission.https://doi.org/10.1371/journal.ppat.1008521 |
| spellingShingle | Yogy Simanjuntak Hui-Ying Ko Yi-Ling Lee Guann-Yi Yu Yi-Ling Lin Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. PLoS Pathogens |
| title | Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. |
| title_full | Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. |
| title_fullStr | Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. |
| title_full_unstemmed | Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. |
| title_short | Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. |
| title_sort | preventive effects of folic acid on zika virus associated poor pregnancy outcomes in immunocompromised mice |
| url | https://doi.org/10.1371/journal.ppat.1008521 |
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