Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory bowel disease

Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory bowel disease

ABSTRACTIntestinal epithelial cell (IEC) regulation of barrier function and mucosal homeostasis enables the establishment of a harmonious gut microenvironment. However, host-derived regulatory networks that modulate intestinal antimicrobial defenses have not been fully defined. Herein we generated m...

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Bibliographic Details
Main Authors: Gengfeng Li, Jian Lin, Xiang Gao, Huiling Su, Ritian Lin, Han Gao, Zhongsheng Feng, Huili Wu, Baisui Feng, Keqiang Zuo, Yingchuan Li, Wei Wu, Leilei Fang, Zhanju Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
GPR65
intestinal epithelial cell
antimicrobial peptide
inflammatory bowel disease
antimicrobial defense
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2257269

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