Mutations in the HFE gene and sporadic amyotrophic lateral sclerosis risk: a meta-analysis of observational studies

Mutations in the HFE gene and sporadic amyotrophic lateral sclerosis risk: a meta-analysis of observational studies

Iron homeostasis dysregulation has been regarded as an important mechanism in neurodegenerative diseases. The H63D and C282Y polymorphisms in the HFE gene may be involved in the development of sporadic amyotrophic lateral sclerosis (ALS) through the disruption of iron homeostasis. However, studies i...

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Bibliographic Details
Main Authors: M. Li, L. Wang, W. Wang, X.L. Qi, Z.Y. Tang
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2014-03-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Amyotrophic lateral sclerosis
HFE
C282Y
H63D
Polymorphism
Meta-analysis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300215&lng=en&tlng=en

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