Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infants
This study assessed the effect of antiretroviral drugs administered to pregnant women on amylase and liver enzymes of the neonate. A prospective study was conducted on 52 neonates divided into three groups: infants born to HIV-infected mothers taking zidovudine (ZDV group, n = 18), infants born to m...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
|
| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300003&lng=en&tlng=en |
| _version_ | 1819208196443602944 |
|---|---|
| author | Patrícia El Beitune Geraldo Duarte Oona Campbell Silvana Maria Quintana Laura C. Rodrigues |
| author_facet | Patrícia El Beitune Geraldo Duarte Oona Campbell Silvana Maria Quintana Laura C. Rodrigues |
| author_sort | Patrícia El Beitune |
| collection | DOAJ |
| description | This study assessed the effect of antiretroviral drugs administered to pregnant women on amylase and liver enzymes of the neonate. A prospective study was conducted on 52 neonates divided into three groups: infants born to HIV-infected mothers taking zidovudine (ZDV group, n = 18), infants born to mothers taking zidovudine + lamivudine + nelfinavir (TT group, n = 22) and infants born to normal women (control group, n = 12). Umbilical cord blood from the newborn infant was used to determine liver transaminases and amylase. Data were analyzed statistically by nonparametric tests, with the level of significance set at p<0.05. The median levels for TT group newborns were 33.3 U/L for oxaloacetic transaminase, 21.5 U/L for pyruvic transaminase, 1.9 mg/dL for total bilirubin, 153 mg/dL for alkaline phosphatase, and 9.6 U/L for amylase. These results did not differ from those obtained for Control newborns or newborns exposed to ZDV alone. No association was observed between the use of antiretroviral drugs during pregnancy and adverse effects on neonatal amylase and hepatic parameters at birth. |
| first_indexed | 2024-12-23T05:35:33Z |
| format | Article |
| id | doaj.art-b6d245acb12941c9af63a638b7811cee |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-23T05:35:33Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-b6d245acb12941c9af63a638b7811cee2022-12-21T17:58:21ZengElsevierBrazilian Journal of Infectious Diseases1678-439111331431710.1590/S1413-86702007000300003S1413-86702007000300003Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infantsPatrícia El Beitune0Geraldo Duarte1Oona Campbell2Silvana Maria Quintana3Laura C. Rodrigues4Universidade de São PauloUniversidade de São PauloLondon School of Hygiene & Tropical MedicineUniversidade de São PauloLondon School of Hygiene & Tropical MedicineThis study assessed the effect of antiretroviral drugs administered to pregnant women on amylase and liver enzymes of the neonate. A prospective study was conducted on 52 neonates divided into three groups: infants born to HIV-infected mothers taking zidovudine (ZDV group, n = 18), infants born to mothers taking zidovudine + lamivudine + nelfinavir (TT group, n = 22) and infants born to normal women (control group, n = 12). Umbilical cord blood from the newborn infant was used to determine liver transaminases and amylase. Data were analyzed statistically by nonparametric tests, with the level of significance set at p<0.05. The median levels for TT group newborns were 33.3 U/L for oxaloacetic transaminase, 21.5 U/L for pyruvic transaminase, 1.9 mg/dL for total bilirubin, 153 mg/dL for alkaline phosphatase, and 9.6 U/L for amylase. These results did not differ from those obtained for Control newborns or newborns exposed to ZDV alone. No association was observed between the use of antiretroviral drugs during pregnancy and adverse effects on neonatal amylase and hepatic parameters at birth.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300003&lng=en&tlng=enCombination antiretroviral therapyhypothesis generationinfant toxicityumbilical cord blood |
| spellingShingle | Patrícia El Beitune Geraldo Duarte Oona Campbell Silvana Maria Quintana Laura C. Rodrigues Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infants Brazilian Journal of Infectious Diseases Combination antiretroviral therapy hypothesis generation infant toxicity umbilical cord blood |
| title | Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infants |
| title_full | Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infants |
| title_fullStr | Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infants |
| title_full_unstemmed | Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infants |
| title_short | Effects of antiretroviral agents during pregnancy on liver enzymes and amylase in HIV-exposed, uninfected newborn infants |
| title_sort | effects of antiretroviral agents during pregnancy on liver enzymes and amylase in hiv exposed uninfected newborn infants |
| topic | Combination antiretroviral therapy hypothesis generation infant toxicity umbilical cord blood |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300003&lng=en&tlng=en |
| work_keys_str_mv | AT patriciaelbeitune effectsofantiretroviralagentsduringpregnancyonliverenzymesandamylaseinhivexposeduninfectednewborninfants AT geraldoduarte effectsofantiretroviralagentsduringpregnancyonliverenzymesandamylaseinhivexposeduninfectednewborninfants AT oonacampbell effectsofantiretroviralagentsduringpregnancyonliverenzymesandamylaseinhivexposeduninfectednewborninfants AT silvanamariaquintana effectsofantiretroviralagentsduringpregnancyonliverenzymesandamylaseinhivexposeduninfectednewborninfants AT lauracrodrigues effectsofantiretroviralagentsduringpregnancyonliverenzymesandamylaseinhivexposeduninfectednewborninfants |