Mitochondrial apoptosis-related gene polymorphisms are associated with responses to anthracycline-based chemotherapy in acute myeloid leukaemia

Mitochondrial apoptosis-related gene polymorphisms are associated with responses to anthracycline-based chemotherapy in acute myeloid leukaemia

BackgroundAlthough anthracyclines are the first-line chemotherapy drugs for treating non-M3 acute myeloid leukaemia (AML), their efficacy remains limited. It is important to identify factors that influence the efficacy of anthracyclines against AML. Mitochondrial apoptosis-related genes play signifi...

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Bibliographic Details
Main Authors: Guangqiang Meng, Mingying Li, Yuan Xia, Yuyan Wu, Yuechan Ma, Min Ji, Jingru Zhang, Jingjing Ye, Tao Sun, Chunyan Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia
mitochondrial apoptosis
single nucleotide polymorphisms
anthracyclines
CRISPR/Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1179937/full

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