Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review
Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable drug resistance from scratch. This group of cel...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-07-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1177466/full |
| _version_ | 1827906152787083264 |
|---|---|
| author | Xian-Wen Liang Bing- Liu Jia-Cheng Chen Zhi Cao Feng-ran Chu Xiong Lin Sheng-Zhong Wang Jin-Cai Wu |
| author_facet | Xian-Wen Liang Bing- Liu Jia-Cheng Chen Zhi Cao Feng-ran Chu Xiong Lin Sheng-Zhong Wang Jin-Cai Wu |
| author_sort | Xian-Wen Liang |
| collection | DOAJ |
| description | Drug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable drug resistance from scratch. This group of cells first enters the drug tolerance state (DT state) under drug pressure, and gradually acquires stable drug resistance through adaptive mutations in this state. Although the specific mechanisms underlying the formation of drug tolerant cells (DTCs) remain unclear, various proteins and signalling pathways have been identified as being involved in the formation of DTCs. In the current review, we summarize the characteristics, molecular mechanisms and therapeutic strategies of DTCs in detail. |
| first_indexed | 2024-03-13T00:51:34Z |
| format | Article |
| id | doaj.art-b6d886f2240d4459884a926098d02d66 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T00:51:34Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b6d886f2240d4459884a926098d02d662023-07-07T12:54:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.11774661177466Characteristics and molecular mechanism of drug-tolerant cells in cancer: a reviewXian-Wen Liang0Bing- Liu1Jia-Cheng Chen2Zhi Cao3Feng-ran Chu4Xiong Lin5Sheng-Zhong Wang6Jin-Cai Wu7Department of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, ChinaDepartment of Gastrointestinal Surgery, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, ChinaDepartment of Gastrointestinal Surgery, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, ChinaDrug resistance in tumours has seriously hindered the therapeutic effect. Tumour drug resistance is divided into primary resistance and acquired resistance, and the recent study has found that a significant proportion of cancer cells can acquire stable drug resistance from scratch. This group of cells first enters the drug tolerance state (DT state) under drug pressure, and gradually acquires stable drug resistance through adaptive mutations in this state. Although the specific mechanisms underlying the formation of drug tolerant cells (DTCs) remain unclear, various proteins and signalling pathways have been identified as being involved in the formation of DTCs. In the current review, we summarize the characteristics, molecular mechanisms and therapeutic strategies of DTCs in detail.https://www.frontiersin.org/articles/10.3389/fonc.2023.1177466/fullcancerdrug tolerancecharacteristicsmolecular mechanismstherapeutic strategies |
| spellingShingle | Xian-Wen Liang Bing- Liu Jia-Cheng Chen Zhi Cao Feng-ran Chu Xiong Lin Sheng-Zhong Wang Jin-Cai Wu Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review Frontiers in Oncology cancer drug tolerance characteristics molecular mechanisms therapeutic strategies |
| title | Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review |
| title_full | Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review |
| title_fullStr | Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review |
| title_full_unstemmed | Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review |
| title_short | Characteristics and molecular mechanism of drug-tolerant cells in cancer: a review |
| title_sort | characteristics and molecular mechanism of drug tolerant cells in cancer a review |
| topic | cancer drug tolerance characteristics molecular mechanisms therapeutic strategies |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1177466/full |
| work_keys_str_mv | AT xianwenliang characteristicsandmolecularmechanismofdrugtolerantcellsincancerareview AT bingliu characteristicsandmolecularmechanismofdrugtolerantcellsincancerareview AT jiachengchen characteristicsandmolecularmechanismofdrugtolerantcellsincancerareview AT zhicao characteristicsandmolecularmechanismofdrugtolerantcellsincancerareview AT fengranchu characteristicsandmolecularmechanismofdrugtolerantcellsincancerareview AT xionglin characteristicsandmolecularmechanismofdrugtolerantcellsincancerareview AT shengzhongwang characteristicsandmolecularmechanismofdrugtolerantcellsincancerareview AT jincaiwu characteristicsandmolecularmechanismofdrugtolerantcellsincancerareview |