Quaternary ammonium-based coating of textiles is effective against bacteria and viruses with a low risk to human health
Abstract While the global healthcare system is slowly recovering from the COVID-19 pandemic, new multi-drug-resistant pathogens are emerging as the next threat. To tackle these challenges there is a need for safe and sustainable antiviral and antibacterial functionalized materials. Here we develop a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-47707-3 |
| _version_ | 1827634482642944000 |
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| author | Philipp Meier Pietro Clement Stefanie Altenried Giacomo Reina Qun Ren Roland Züst Olivier Enger Francis Choi Nikolaus Nestle Ted Deisenroth Peter Neubauer Peter Wick |
| author_facet | Philipp Meier Pietro Clement Stefanie Altenried Giacomo Reina Qun Ren Roland Züst Olivier Enger Francis Choi Nikolaus Nestle Ted Deisenroth Peter Neubauer Peter Wick |
| author_sort | Philipp Meier |
| collection | DOAJ |
| description | Abstract While the global healthcare system is slowly recovering from the COVID-19 pandemic, new multi-drug-resistant pathogens are emerging as the next threat. To tackle these challenges there is a need for safe and sustainable antiviral and antibacterial functionalized materials. Here we develop an 'easy-to-apply' procedure for the surface functionalization of textiles, rendering them antiviral and antibacterial and assessing the performance of these textiles. A metal-free quaternary ammonium-based coating was applied homogeneously and non-covalently to hospital curtains. Abrasion, durability testing, and aging resulted in little change in the performance of the treated textile. Additionally, qualitative and quantitative antibacterial assays on Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumanii revealed excellent antibacterial activity with a CFU reduction of 98–100% within only 4 h of exposure. The treated curtain was aged 6 months before testing. Similarly, the antiviral activity tested according to ISO-18184 with murine hepatitis virus (MHV) showed > 99% viral reduction with the functionalized curtain. Also, the released active compounds of the coating 24 ± 5 µg mL−1 revealed no acute in vitro skin toxicity (IC50: 95 µg mL−1) and skin sensitization. This study emphasizes the potential of safe and sustainable metal-free textile coatings for the rapid antiviral and antibacterial functionalization of textiles. |
| first_indexed | 2024-03-09T15:13:59Z |
| format | Article |
| id | doaj.art-b6d9ad6c01d34f12b78964e89e0c4d8b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:13:59Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b6d9ad6c01d34f12b78964e89e0c4d8b2023-11-26T13:12:36ZengNature PortfolioScientific Reports2045-23222023-11-0113111210.1038/s41598-023-47707-3Quaternary ammonium-based coating of textiles is effective against bacteria and viruses with a low risk to human healthPhilipp Meier0Pietro Clement1Stefanie Altenried2Giacomo Reina3Qun Ren4Roland Züst5Olivier Enger6Francis Choi7Nikolaus Nestle8Ted Deisenroth9Peter Neubauer10Peter Wick11Particles-Biology Interactions Laboratory, Empa-Swiss Federal Laboratories for Materials Science and TechnologyParticles-Biology Interactions Laboratory, Empa-Swiss Federal Laboratories for Materials Science and TechnologyBiointerfaces Laboratory, Empa-Swiss Federal Laboratories for Materials Science and TechnologyParticles-Biology Interactions Laboratory, Empa-Swiss Federal Laboratories for Materials Science and TechnologyBiointerfaces Laboratory, Empa-Swiss Federal Laboratories for Materials Science and TechnologyFederal Office for Civil Protection FOCP, Spiez LaboratoryTechnology Scouting & Incubation, BASF Schweiz AGBASF CorporationBASF SEFormulation Research, BASF CorporationChair of Bioprocess Engineering, Institute of Biotechnology, TU BerlinParticles-Biology Interactions Laboratory, Empa-Swiss Federal Laboratories for Materials Science and TechnologyAbstract While the global healthcare system is slowly recovering from the COVID-19 pandemic, new multi-drug-resistant pathogens are emerging as the next threat. To tackle these challenges there is a need for safe and sustainable antiviral and antibacterial functionalized materials. Here we develop an 'easy-to-apply' procedure for the surface functionalization of textiles, rendering them antiviral and antibacterial and assessing the performance of these textiles. A metal-free quaternary ammonium-based coating was applied homogeneously and non-covalently to hospital curtains. Abrasion, durability testing, and aging resulted in little change in the performance of the treated textile. Additionally, qualitative and quantitative antibacterial assays on Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumanii revealed excellent antibacterial activity with a CFU reduction of 98–100% within only 4 h of exposure. The treated curtain was aged 6 months before testing. Similarly, the antiviral activity tested according to ISO-18184 with murine hepatitis virus (MHV) showed > 99% viral reduction with the functionalized curtain. Also, the released active compounds of the coating 24 ± 5 µg mL−1 revealed no acute in vitro skin toxicity (IC50: 95 µg mL−1) and skin sensitization. This study emphasizes the potential of safe and sustainable metal-free textile coatings for the rapid antiviral and antibacterial functionalization of textiles.https://doi.org/10.1038/s41598-023-47707-3 |
| spellingShingle | Philipp Meier Pietro Clement Stefanie Altenried Giacomo Reina Qun Ren Roland Züst Olivier Enger Francis Choi Nikolaus Nestle Ted Deisenroth Peter Neubauer Peter Wick Quaternary ammonium-based coating of textiles is effective against bacteria and viruses with a low risk to human health Scientific Reports |
| title | Quaternary ammonium-based coating of textiles is effective against bacteria and viruses with a low risk to human health |
| title_full | Quaternary ammonium-based coating of textiles is effective against bacteria and viruses with a low risk to human health |
| title_fullStr | Quaternary ammonium-based coating of textiles is effective against bacteria and viruses with a low risk to human health |
| title_full_unstemmed | Quaternary ammonium-based coating of textiles is effective against bacteria and viruses with a low risk to human health |
| title_short | Quaternary ammonium-based coating of textiles is effective against bacteria and viruses with a low risk to human health |
| title_sort | quaternary ammonium based coating of textiles is effective against bacteria and viruses with a low risk to human health |
| url | https://doi.org/10.1038/s41598-023-47707-3 |
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