Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases
PURPOSEWe aimed to evaluate the effectiveness and safety of radioembolization with yttrium-90 (90Y) microspheres in cases with unresectable neuroendocrine tumor liver metastases (NETLMs).METHODSThirty patients (mean age, 55 years) underwent resin-based 90Y radioembolization for unresectable NETLM at...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-01-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/radioembolization-with-yttrium-90-resin-microspher/55927
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| _version_ | 1797691169253097472 |
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| author | Ahmet Peker Okan Çiçek Çiğdem Soydal Nuriye Özlem Küçük Sadık Bilgiç |
| author_facet | Ahmet Peker Okan Çiçek Çiğdem Soydal Nuriye Özlem Küçük Sadık Bilgiç |
| author_sort | Ahmet Peker |
| collection | DOAJ |
| description | PURPOSEWe aimed to evaluate the effectiveness and safety of radioembolization with yttrium-90 (90Y) microspheres in cases with unresectable neuroendocrine tumor liver metastases (NETLMs).METHODSThirty patients (mean age, 55 years) underwent resin-based 90Y radioembolization for unresectable NETLM at a single institution between April 2008 and June 2013. Post-treatment tumor response was assessed by cross-sectional imaging using the Response Evaluation Criteria in Solid Tumors (RECIST). Prognostic variables that affected survival were determined.RESULTSThe mean follow-up was 23.0±19.4 months and the median overall survival was 39 months (95% CI, 12.6–65.4 months), with one- and two-year survival rates of 71% and 45%, respectively. Imaging follow-up using RECIST at three-month intervals demonstrated partial response in 43%, complete remission in 3%, stable disease in 37%, and progressive disease in 17% of patients. Extent of tumor involvement was found to have a statistically significant influence on overall survival (P = 0.03). The existence of extrahepatic disease at the time of radioembolization, radiographic response, age, and primary neuroendocrine tumor site were not significant prognostic factors.CONCLUSIONThe current study demonstrates the effectiveness and safety of radioembolization for the treatment of unresectable NETLMs. We identified that the extent of tumor involvement has a significant effect on overall survival. The use of imaging methods reflecting metabolic activity or cellularity such as scintigraphy or diffusion-weighted MRI would be more appropriate, for the response evaluation of liver metastases after radioembolization. |
| first_indexed | 2024-03-12T02:10:27Z |
| format | Article |
| id | doaj.art-b6da1fd9ed39462ca59d9f222956f2f6 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:10:27Z |
| publishDate | 2015-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-b6da1fd9ed39462ca59d9f222956f2f62023-09-06T13:50:48ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122015-01-01211545910.5152/dir.2014.1403613049054Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastasesAhmet Peker0Okan Çiçek1Çiğdem Soydal2Nuriye Özlem Küçük3Sadık Bilgiç4 Department of Radiology Ankara University Medical School, Ankara, Turkey Department of Radiology, Hakkari State Hospital, Hakkari, Turkey Department of Nuclear Medicine, Ankara University Medical School, Ankara, Turkey Department of Nuclear Medicine, Ankara University Medical School, Ankara, Turkey Department of Radiology Ankara University Medical School, Ankara, Turkey PURPOSEWe aimed to evaluate the effectiveness and safety of radioembolization with yttrium-90 (90Y) microspheres in cases with unresectable neuroendocrine tumor liver metastases (NETLMs).METHODSThirty patients (mean age, 55 years) underwent resin-based 90Y radioembolization for unresectable NETLM at a single institution between April 2008 and June 2013. Post-treatment tumor response was assessed by cross-sectional imaging using the Response Evaluation Criteria in Solid Tumors (RECIST). Prognostic variables that affected survival were determined.RESULTSThe mean follow-up was 23.0±19.4 months and the median overall survival was 39 months (95% CI, 12.6–65.4 months), with one- and two-year survival rates of 71% and 45%, respectively. Imaging follow-up using RECIST at three-month intervals demonstrated partial response in 43%, complete remission in 3%, stable disease in 37%, and progressive disease in 17% of patients. Extent of tumor involvement was found to have a statistically significant influence on overall survival (P = 0.03). The existence of extrahepatic disease at the time of radioembolization, radiographic response, age, and primary neuroendocrine tumor site were not significant prognostic factors.CONCLUSIONThe current study demonstrates the effectiveness and safety of radioembolization for the treatment of unresectable NETLMs. We identified that the extent of tumor involvement has a significant effect on overall survival. The use of imaging methods reflecting metabolic activity or cellularity such as scintigraphy or diffusion-weighted MRI would be more appropriate, for the response evaluation of liver metastases after radioembolization. http://www.dirjournal.org/archives/archive-detail/article-preview/radioembolization-with-yttrium-90-resin-microspher/55927 |
| spellingShingle | Ahmet Peker Okan Çiçek Çiğdem Soydal Nuriye Özlem Küçük Sadık Bilgiç Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases Diagnostic and Interventional Radiology |
| title | Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases |
| title_full | Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases |
| title_fullStr | Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases |
| title_full_unstemmed | Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases |
| title_short | Radioembolization with yttrium-90 resin microspheres for neuroendocrine tumor liver metastases |
| title_sort | radioembolization with yttrium 90 resin microspheres for neuroendocrine tumor liver metastases |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/radioembolization-with-yttrium-90-resin-microspher/55927
|
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