Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary Fructose
The harmful effect of a long-term high-fructose diet is well established, but the age-dependent physiological responses that can be triggered by a short-term high-fructose diet in skeletal muscles have not been deeply explored. Therefore, the aim of this work was to compare the alterations in mitoch...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/2/299 |
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| author | Cristina Gatto Angela Di Porzio Raffaella Crescenzo Valentina Barrella Susanna Iossa Arianna Mazzoli |
| author_facet | Cristina Gatto Angela Di Porzio Raffaella Crescenzo Valentina Barrella Susanna Iossa Arianna Mazzoli |
| author_sort | Cristina Gatto |
| collection | DOAJ |
| description | The harmful effect of a long-term high-fructose diet is well established, but the age-dependent physiological responses that can be triggered by a short-term high-fructose diet in skeletal muscles have not been deeply explored. Therefore, the aim of this work was to compare the alterations in mitochondrial energetic and insulin responsiveness in the skeletal muscle induced by a short-term (2 weeks) fructose feeding in rats of different ages. For this purpose, fructose and uric acid levels, insulin sensitivity, mitochondrial bioenergetics and oxidative status were evaluated in the skeletal muscles from young (30 days old) and adult (90 days old) rats. We showed that, even in the short term, a high-fructose diet has a strong impact on skeletal muscle metabolism, with more marked effects in young rats than in adults ones. In fact, despite both groups showing a decrease in insulin sensitivity, the marked mitochondrial dysfunction was found only in the young rats, thus leading to an increase in the mitochondrial production of ROS, and therefore, in oxidative damage. These findings underscore the need to reduce fructose consumption, especially in young people, to preserve the maintenance of a metabolically healthy status. |
| first_indexed | 2024-03-11T09:14:17Z |
| format | Article |
| id | doaj.art-b6dc0d7b057b4b9ab661db99dd1ad672 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T09:14:17Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-b6dc0d7b057b4b9ab661db99dd1ad6722023-11-16T18:46:12ZengMDPI AGAntioxidants2076-39212023-01-0112229910.3390/antiox12020299Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary FructoseCristina Gatto0Angela Di Porzio1Raffaella Crescenzo2Valentina Barrella3Susanna Iossa4Arianna Mazzoli5Department of Biology, University of Naples Federico II, Complesso Universitario Monte Sant’Angelo, Via Cinthia, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, Complesso Universitario Monte Sant’Angelo, Via Cinthia, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, Complesso Universitario Monte Sant’Angelo, Via Cinthia, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, Complesso Universitario Monte Sant’Angelo, Via Cinthia, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, Complesso Universitario Monte Sant’Angelo, Via Cinthia, 80126 Naples, ItalyDepartment of Biology, University of Naples Federico II, Complesso Universitario Monte Sant’Angelo, Via Cinthia, 80126 Naples, ItalyThe harmful effect of a long-term high-fructose diet is well established, but the age-dependent physiological responses that can be triggered by a short-term high-fructose diet in skeletal muscles have not been deeply explored. Therefore, the aim of this work was to compare the alterations in mitochondrial energetic and insulin responsiveness in the skeletal muscle induced by a short-term (2 weeks) fructose feeding in rats of different ages. For this purpose, fructose and uric acid levels, insulin sensitivity, mitochondrial bioenergetics and oxidative status were evaluated in the skeletal muscles from young (30 days old) and adult (90 days old) rats. We showed that, even in the short term, a high-fructose diet has a strong impact on skeletal muscle metabolism, with more marked effects in young rats than in adults ones. In fact, despite both groups showing a decrease in insulin sensitivity, the marked mitochondrial dysfunction was found only in the young rats, thus leading to an increase in the mitochondrial production of ROS, and therefore, in oxidative damage. These findings underscore the need to reduce fructose consumption, especially in young people, to preserve the maintenance of a metabolically healthy status.https://www.mdpi.com/2076-3921/12/2/299fructoseskeletal musclemitochondriaoxidative stressproton leakinsulin resistance |
| spellingShingle | Cristina Gatto Angela Di Porzio Raffaella Crescenzo Valentina Barrella Susanna Iossa Arianna Mazzoli Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary Fructose Antioxidants fructose skeletal muscle mitochondria oxidative stress proton leak insulin resistance |
| title | Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary Fructose |
| title_full | Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary Fructose |
| title_fullStr | Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary Fructose |
| title_full_unstemmed | Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary Fructose |
| title_short | Age-Dependent Skeletal Muscle Mitochondrial Response to Short-Term Increased Dietary Fructose |
| title_sort | age dependent skeletal muscle mitochondrial response to short term increased dietary fructose |
| topic | fructose skeletal muscle mitochondria oxidative stress proton leak insulin resistance |
| url | https://www.mdpi.com/2076-3921/12/2/299 |
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