BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females
The pathophysiological processes undermining brain functioning decades before the onset of the clinical symptoms associated with dementia are still not well understood. Several heritability studies have reported that the Brain Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism could co...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2018.00684/full |
| _version_ | 1819101708394954752 |
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| author | Inmaculada C. Rodríguez-Rojo Inmaculada C. Rodríguez-Rojo Pablo Cuesta Pablo Cuesta María Eugenia López María Eugenia López Jaisalmer de Frutos-Lucas Jaisalmer de Frutos-Lucas Ricardo Bruña Ricardo Bruña Ricardo Bruña Ernesto Pereda Ernesto Pereda Ana Barabash Ana Barabash Pedro Montejo Mercedes Montenegro-Peña Alberto Marcos Ramón López-Higes Alberto Fernández Alberto Fernández Fernando Maestú Fernando Maestú Fernando Maestú |
| author_facet | Inmaculada C. Rodríguez-Rojo Inmaculada C. Rodríguez-Rojo Pablo Cuesta Pablo Cuesta María Eugenia López María Eugenia López Jaisalmer de Frutos-Lucas Jaisalmer de Frutos-Lucas Ricardo Bruña Ricardo Bruña Ricardo Bruña Ernesto Pereda Ernesto Pereda Ana Barabash Ana Barabash Pedro Montejo Mercedes Montenegro-Peña Alberto Marcos Ramón López-Higes Alberto Fernández Alberto Fernández Fernando Maestú Fernando Maestú Fernando Maestú |
| author_sort | Inmaculada C. Rodríguez-Rojo |
| collection | DOAJ |
| description | The pathophysiological processes undermining brain functioning decades before the onset of the clinical symptoms associated with dementia are still not well understood. Several heritability studies have reported that the Brain Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging. This mutation may affect brain functional connectivity (FC), especially in those who are carriers of the BDNF Met allele. The aim of this work was to explore the influence of the BDNF Val66Met polymorphism in whole brain eyes-closed, resting-state magnetoencephalography (MEG) FC in a sample of 36 cognitively intact (CI) older females. All of them were ε3ε3 homozygotes for the apolipoprotein E (APOE) gene and were divided into two subgroups according to the presence of the Met allele: Val/Met group (n = 16) and Val/Val group (n = 20). They did not differ in age, years of education, Mini-Mental State Examination scores, or normalized hippocampal volumes. Our results showed reduced antero-posterior gamma band FC within the Val/Met genetic risk group, which may be caused by a GABAergic network impairment. Despite the lack of cognitive decline, these results might suggest a selective brain network vulnerability due to the carriage of the BDNF Met allele, which is linked to a potential progression to dementia. This neurophysiological signature, as tracked with MEG FC, indicates that age-related brain functioning changes could be mediated by the influence of particular genetic risk factors. |
| first_indexed | 2024-12-22T01:22:58Z |
| format | Article |
| id | doaj.art-b6dc7b936d654c0284be5ad1d4a646bb |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-22T01:22:58Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-b6dc7b936d654c0284be5ad1d4a646bb2022-12-21T18:43:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-10-011210.3389/fnins.2018.00684401630BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older FemalesInmaculada C. Rodríguez-Rojo0Inmaculada C. Rodríguez-Rojo1Pablo Cuesta2Pablo Cuesta3María Eugenia López4María Eugenia López5Jaisalmer de Frutos-Lucas6Jaisalmer de Frutos-Lucas7Ricardo Bruña8Ricardo Bruña9Ricardo Bruña10Ernesto Pereda11Ernesto Pereda12Ana Barabash13Ana Barabash14Pedro Montejo15Mercedes Montenegro-Peña16Alberto Marcos17Ramón López-Higes18Alberto Fernández19Alberto Fernández20Fernando Maestú21Fernando Maestú22Fernando Maestú23Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense and Universidad Politécnica de Madrid, Madrid, SpainDepartment of Experimental Psychology, Cognitive Processes and Speech Therapy, Universidad Complutense de Madrid, Madrid, SpainLaboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense and Universidad Politécnica de Madrid, Madrid, SpainElectrical Engineering and Bioengineering Lab, Department of Industrial Engineering and IUNE, Universidad de La Laguna, Tenerife, SpainLaboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense and Universidad Politécnica de Madrid, Madrid, SpainDepartment of Experimental Psychology, Cognitive Processes and Speech Therapy, Universidad Complutense de Madrid, Madrid, SpainLaboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense and Universidad Politécnica de Madrid, Madrid, SpainBiological and Health Psychology Department, Universidad Autónoma de Madrid, Madrid, SpainLaboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense and Universidad Politécnica de Madrid, Madrid, SpainDepartment of Experimental Psychology, Cognitive Processes and Speech Therapy, Universidad Complutense de Madrid, Madrid, SpainNetworking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, SpainLaboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense and Universidad Politécnica de Madrid, Madrid, SpainElectrical Engineering and Bioengineering Lab, Department of Industrial Engineering and IUNE, Universidad de La Laguna, Tenerife, SpainLaboratory of Psychoneuroendocrinology and Genetics, Hospital Clínico San Carlos, Madrid, SpainInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainCenter for the Prevention of Cognitive Impairment, Public Health Institute, Madrid-Salud, Madrid, SpainCenter for the Prevention of Cognitive Impairment, Public Health Institute, Madrid-Salud, Madrid, SpainNeurology Department, Hospital Clínico San Carlos, Madrid, SpainDepartment of Experimental Psychology, Cognitive Processes and Speech Therapy, Universidad Complutense de Madrid, Madrid, SpainLaboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense and Universidad Politécnica de Madrid, Madrid, Spain0Department of Legal Medicine, Psychiatry, and Pathology, Universidad Complutense de Madrid, Madrid, SpainLaboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense and Universidad Politécnica de Madrid, Madrid, SpainDepartment of Experimental Psychology, Cognitive Processes and Speech Therapy, Universidad Complutense de Madrid, Madrid, SpainNetworking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, SpainThe pathophysiological processes undermining brain functioning decades before the onset of the clinical symptoms associated with dementia are still not well understood. Several heritability studies have reported that the Brain Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging. This mutation may affect brain functional connectivity (FC), especially in those who are carriers of the BDNF Met allele. The aim of this work was to explore the influence of the BDNF Val66Met polymorphism in whole brain eyes-closed, resting-state magnetoencephalography (MEG) FC in a sample of 36 cognitively intact (CI) older females. All of them were ε3ε3 homozygotes for the apolipoprotein E (APOE) gene and were divided into two subgroups according to the presence of the Met allele: Val/Met group (n = 16) and Val/Val group (n = 20). They did not differ in age, years of education, Mini-Mental State Examination scores, or normalized hippocampal volumes. Our results showed reduced antero-posterior gamma band FC within the Val/Met genetic risk group, which may be caused by a GABAergic network impairment. Despite the lack of cognitive decline, these results might suggest a selective brain network vulnerability due to the carriage of the BDNF Met allele, which is linked to a potential progression to dementia. This neurophysiological signature, as tracked with MEG FC, indicates that age-related brain functioning changes could be mediated by the influence of particular genetic risk factors.https://www.frontiersin.org/article/10.3389/fnins.2018.00684/fullBDNF Val66Metmagnetoencephalographygamma rhythmscognitive functioninghealthy agingAlzheimer's disease |
| spellingShingle | Inmaculada C. Rodríguez-Rojo Inmaculada C. Rodríguez-Rojo Pablo Cuesta Pablo Cuesta María Eugenia López María Eugenia López Jaisalmer de Frutos-Lucas Jaisalmer de Frutos-Lucas Ricardo Bruña Ricardo Bruña Ricardo Bruña Ernesto Pereda Ernesto Pereda Ana Barabash Ana Barabash Pedro Montejo Mercedes Montenegro-Peña Alberto Marcos Ramón López-Higes Alberto Fernández Alberto Fernández Fernando Maestú Fernando Maestú Fernando Maestú BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females Frontiers in Neuroscience BDNF Val66Met magnetoencephalography gamma rhythms cognitive functioning healthy aging Alzheimer's disease |
| title | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
| title_full | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
| title_fullStr | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
| title_full_unstemmed | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
| title_short | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
| title_sort | bdnf val66met polymorphism and gamma band disruption in resting state brain functional connectivity a magnetoencephalography study in cognitively intact older females |
| topic | BDNF Val66Met magnetoencephalography gamma rhythms cognitive functioning healthy aging Alzheimer's disease |
| url | https://www.frontiersin.org/article/10.3389/fnins.2018.00684/full |
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