Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease
The incidence of autoimmune disease continues to rise, which urges for new prevention and treatment modalities. The composition of the gut microbiota is associated with both susceptibility and progression of disease. Nutrition significantly shapes the gut microbial composition, and poses as such a m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1107016/full |
| _version_ | 1828066534252085248 |
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| author | Olaf F. A. Larsen |
| author_facet | Olaf F. A. Larsen |
| author_sort | Olaf F. A. Larsen |
| collection | DOAJ |
| description | The incidence of autoimmune disease continues to rise, which urges for new prevention and treatment modalities. The composition of the gut microbiota is associated with both susceptibility and progression of disease. Nutrition significantly shapes the gut microbial composition, and poses as such a modality for both prevention and treatment/adjuvant therapy. At very young age, nutritional intervention targeting the gut microbiota is still possible within a one-size-fits all regime, accompanied by a relatively high effect size. As ageing results in higher interindividual variation induced by cumulative exposome factors, a more personalized approach is needed, having a higher effect size than that of current nutritional intervention. As such, supplementation of microbial consortia consisting of keystone taxa and microbial guilds that are involved in the pathophysiology seem a promising direction to lower the burden of autoimmune disease. |
| first_indexed | 2024-04-10T23:32:08Z |
| format | Article |
| id | doaj.art-b6dd5d41bf7c4faf8f8e8b3d11ed0102 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T23:32:08Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-b6dd5d41bf7c4faf8f8e8b3d11ed01022023-01-12T04:57:34ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-01-01910.3389/fnut.2022.11070161107016Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune diseaseOlaf F. A. LarsenThe incidence of autoimmune disease continues to rise, which urges for new prevention and treatment modalities. The composition of the gut microbiota is associated with both susceptibility and progression of disease. Nutrition significantly shapes the gut microbial composition, and poses as such a modality for both prevention and treatment/adjuvant therapy. At very young age, nutritional intervention targeting the gut microbiota is still possible within a one-size-fits all regime, accompanied by a relatively high effect size. As ageing results in higher interindividual variation induced by cumulative exposome factors, a more personalized approach is needed, having a higher effect size than that of current nutritional intervention. As such, supplementation of microbial consortia consisting of keystone taxa and microbial guilds that are involved in the pathophysiology seem a promising direction to lower the burden of autoimmune disease.https://www.frontiersin.org/articles/10.3389/fnut.2022.1107016/fullgut microbiotaold friendsautoimmuneprobioticsnutritionOne Health |
| spellingShingle | Olaf F. A. Larsen Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease Frontiers in Nutrition gut microbiota old friends autoimmune probiotics nutrition One Health |
| title | Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease |
| title_full | Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease |
| title_fullStr | Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease |
| title_full_unstemmed | Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease |
| title_short | Nurturing by nutrition: On the future of gut microbiota management strategies for autoimmune disease |
| title_sort | nurturing by nutrition on the future of gut microbiota management strategies for autoimmune disease |
| topic | gut microbiota old friends autoimmune probiotics nutrition One Health |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1107016/full |
| work_keys_str_mv | AT olaffalarsen nurturingbynutritiononthefutureofgutmicrobiotamanagementstrategiesforautoimmunedisease |