PTCH1 mutations' role in keratocystic odontogenic tumors and nevoid basal cell carcinoma syndrome

PTCH1 mutations' role in keratocystic odontogenic tumors and nevoid basal cell carcinoma syndrome

Nevoid basal cell carcinoma syndrome (NBCCS) is a typical autosomal dominant disorder distinguished by malformations in development and an increased susceptibility to cancer. Keratocystic Odontogenic Tumors (KOTs) are highly malignant lesions of the jaw that, in isolation or conjunction with NBCCS,...

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Bibliographic Details
Main Authors: Archana Behera, Mukesh Kumar Dharmalingam Jothinathan
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Oral Oncology Reports
Subjects:
Keratocystic odontogenic tumors (KOTs)
Nevoid basal cell carcinoma syndrome (NBCCS)
PTCH1
Smoothened (SMO) genes
Sonic hedgehog (SHH) pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2772906024003406

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http://www.sciencedirect.com/science/article/pii/S2772906024003406

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