The Most Common Genetic Factors of Alzheimer’s disease and Importance of Fruit Fly in Disease Modeling Studies
Background & Objective: Alzheimer’s disease (AD) is the major frequent form of dementia in which progressive widespread neuronal death leads to death in affected individuals. AD is a highly heritable disorder and diverse genetic factors contribute to its cause and development. The aim of the pre...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2020-11-01
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| Series: | Journal of Advanced Biomedical Sciences |
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| Online Access: | http://jabs.fums.ac.ir/article-1-2576-en.pdf |
| _version_ | 1797679579471544320 |
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| author | Mohammad Haddadi |
| author_facet | Mohammad Haddadi |
| author_sort | Mohammad Haddadi |
| collection | DOAJ |
| description | Background & Objective: Alzheimer’s disease (AD) is the major frequent form of dementia in which progressive widespread neuronal death leads to death in affected individuals. AD is a highly heritable disorder and diverse genetic factors contribute to its cause and development. The aim of the present review is to introduce genetic factors involved in AD and to elucidate contributions of Drosophila melanogaster (fruit fly) in the study of mechanisms by which pathogenicity of identified genes occurs.
Materials & Methods: In this study, 100 published research papers on the genetics of AD and modelling AD in Drosophila melanogaster were investigated. The English articles were retrieved from verified biological databases published from 1992 to 2020.
Result: Based on the presence of clinical symptoms AD is divided into two main types: early-onset AD (EOAD) and late-onset AD (LOAD). The genetic basis for EOAD is mainly related to mutations in genes involved in the production, aggregation, and clearance of amyloid-beta (Aβ). The genetics of LOAD is more complicated and a mixture of common but less-penetrant genetic factors, such as E4 isoform of apolipoprotein E (APOE), interacts with environmental cues and epigenetic influences. Functional studies using fruit flies demonstrate an association between Aß aggregation/clearance and tau phosphorylation. It has been shown that Aß, tau, and APOE4 contribute to damage in axonal terminals in AD conditions.
Conclusion: Knowing the genetic basis of AD and mechanisms that underlie their pathogenicity can be essential for developing effective treatment strategies. Drosophila melanogaster as an ideal model organism with unique genetic characteristics possesses a crucial functional role in the study of the molecular mechanisms of human neurological disorders. |
| first_indexed | 2024-03-11T23:16:50Z |
| format | Article |
| id | doaj.art-b6dff04f57a9411d97201ad63878335c |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:16:50Z |
| publishDate | 2020-11-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-b6dff04f57a9411d97201ad63878335c2023-09-20T21:28:07ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232020-11-0110430853096The Most Common Genetic Factors of Alzheimer’s disease and Importance of Fruit Fly in Disease Modeling StudiesMohammad Haddadi0 Department of Biology, Faculty of Basic Sciences, University of Zabol, Zabol, Iran Background & Objective: Alzheimer’s disease (AD) is the major frequent form of dementia in which progressive widespread neuronal death leads to death in affected individuals. AD is a highly heritable disorder and diverse genetic factors contribute to its cause and development. The aim of the present review is to introduce genetic factors involved in AD and to elucidate contributions of Drosophila melanogaster (fruit fly) in the study of mechanisms by which pathogenicity of identified genes occurs. Materials & Methods: In this study, 100 published research papers on the genetics of AD and modelling AD in Drosophila melanogaster were investigated. The English articles were retrieved from verified biological databases published from 1992 to 2020. Result: Based on the presence of clinical symptoms AD is divided into two main types: early-onset AD (EOAD) and late-onset AD (LOAD). The genetic basis for EOAD is mainly related to mutations in genes involved in the production, aggregation, and clearance of amyloid-beta (Aβ). The genetics of LOAD is more complicated and a mixture of common but less-penetrant genetic factors, such as E4 isoform of apolipoprotein E (APOE), interacts with environmental cues and epigenetic influences. Functional studies using fruit flies demonstrate an association between Aß aggregation/clearance and tau phosphorylation. It has been shown that Aß, tau, and APOE4 contribute to damage in axonal terminals in AD conditions. Conclusion: Knowing the genetic basis of AD and mechanisms that underlie their pathogenicity can be essential for developing effective treatment strategies. Drosophila melanogaster as an ideal model organism with unique genetic characteristics possesses a crucial functional role in the study of the molecular mechanisms of human neurological disorders.http://jabs.fums.ac.ir/article-1-2576-en.pdfalzheimer’s diseasegenetic variantsfunctional studiesdrosophila melanogaster |
| spellingShingle | Mohammad Haddadi The Most Common Genetic Factors of Alzheimer’s disease and Importance of Fruit Fly in Disease Modeling Studies Journal of Advanced Biomedical Sciences alzheimer’s disease genetic variants functional studies drosophila melanogaster |
| title | The Most Common Genetic Factors of Alzheimer’s disease and Importance of Fruit Fly in Disease Modeling Studies |
| title_full | The Most Common Genetic Factors of Alzheimer’s disease and Importance of Fruit Fly in Disease Modeling Studies |
| title_fullStr | The Most Common Genetic Factors of Alzheimer’s disease and Importance of Fruit Fly in Disease Modeling Studies |
| title_full_unstemmed | The Most Common Genetic Factors of Alzheimer’s disease and Importance of Fruit Fly in Disease Modeling Studies |
| title_short | The Most Common Genetic Factors of Alzheimer’s disease and Importance of Fruit Fly in Disease Modeling Studies |
| title_sort | most common genetic factors of alzheimer s disease and importance of fruit fly in disease modeling studies |
| topic | alzheimer’s disease genetic variants functional studies drosophila melanogaster |
| url | http://jabs.fums.ac.ir/article-1-2576-en.pdf |
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