Changes in the characteristics of community-onset fluoroquinolone-resistant Escherichia coli isolates causing community-acquired acute pyelonephritis in South Korea
Purpose: This study aimed to examine the changes in the characteristics of community-onset fluoroquinolone-resistant (FQ-R) Escherichia coli isolates causing community-acquired acute pyelonephritis (APN) in South Korea. Methods: Blood or urine samples were prospectively collected from patients aged...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-08-01
|
| Series: | Journal of Microbiology, Immunology and Infection |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118222000020 |
| _version_ | 1811281238906896384 |
|---|---|
| author | Bongyoung Kim Jeoungyeon Kim Hyun-uk Jo Ki Tae Kwon Seong-yeol Ryu Seong-Heon Wie Jieun Kim Se Yoon Park Kyung-Wook Hong Hye In Kim Hyun ah Kim Mi-Hee Kim Mi Hyun Bae Yong-Hak Sohn Jieun Kim Yangsoon Lee Hyunjoo Pai |
| author_facet | Bongyoung Kim Jeoungyeon Kim Hyun-uk Jo Ki Tae Kwon Seong-yeol Ryu Seong-Heon Wie Jieun Kim Se Yoon Park Kyung-Wook Hong Hye In Kim Hyun ah Kim Mi-Hee Kim Mi Hyun Bae Yong-Hak Sohn Jieun Kim Yangsoon Lee Hyunjoo Pai |
| author_sort | Bongyoung Kim |
| collection | DOAJ |
| description | Purpose: This study aimed to examine the changes in the characteristics of community-onset fluoroquinolone-resistant (FQ-R) Escherichia coli isolates causing community-acquired acute pyelonephritis (APN) in South Korea. Methods: Blood or urine samples were prospectively collected from patients aged ≥15 years with community-acquired APN who were admitted to one of the eight Korean hospitals included in this study between September 2017 and August 2018. Phylogenetic typing, multilocus sequence typing, and molecular characterization of β-lactamase resistance and plasmid-mediated quinolone resistance (PMQR) determinants were performed. The data were compared with those from a previous study with the same design conducted in 2010–2011. Results: A total of 300 and 346 isolates were identified in 2010–2011 and 2017–2018, respectively. Among them, 76 (22.0%) and 77 (25.7%) FQ-R isolates were identified in 2010–2011 and 2017–2018, respectively. A significantly higher antimicrobial resistance against third-to fourth-generation cephalosporins, including cefotaxime (23.9% vs. 77.9%, P < 0.001), were observed among FQ-R isolates in 2017–2018 than among those in 2010–2011. A higher proportion of ST131 isolates (27.6% vs. 66.2%, P < 0.001), as well as isolates that had extended-spectrum β-lactamase (ESBL)/plasmid-mediated AmpC β-lactamase (PABL) (23.7% vs. 79.2%, P < 0.001), was observed in 2017–2018 than in 2010–2011. Further, more PMQR determinants (11.8% vs. 40.8%, P < 0.001) were observed in 2017–2018 than in 2010–2011. Conclusions: Among uropathogenic FQ-R E. coli isolates in South Korea, the prevalence of ST131 and the proportion of isolates containing ESBL and/or PMQR determinants have increased. |
| first_indexed | 2024-04-13T01:30:12Z |
| format | Article |
| id | doaj.art-b6dff93a0dd148cf97b8c257afb1d6f6 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-04-13T01:30:12Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-b6dff93a0dd148cf97b8c257afb1d6f62022-12-22T03:08:32ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822022-08-01554678685Changes in the characteristics of community-onset fluoroquinolone-resistant Escherichia coli isolates causing community-acquired acute pyelonephritis in South KoreaBongyoung Kim0Jeoungyeon Kim1Hyun-uk Jo2Ki Tae Kwon3Seong-yeol Ryu4Seong-Heon Wie5Jieun Kim6Se Yoon Park7Kyung-Wook Hong8Hye In Kim9Hyun ah Kim10Mi-Hee Kim11Mi Hyun Bae12Yong-Hak Sohn13Jieun Kim14Yangsoon Lee15Hyunjoo Pai16Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, South Korea; Corresponding author. Department of Internal Medicine, Hanyang University College of Medicine, 222-1, Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. Fax: +82 2 2298 9183.Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, South KoreaDepartment of Urology, Good Moonhwa Hospital, Busan, South KoreaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South KoreaDepartment of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South KoreaDepartment of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South KoreaDepartment of Internal Medicine, College of Medicine, Hanyang University, Seoul, South KoreaDivision of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University, Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, South KoreaDivision of Infectious Diseases, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South KoreaDepartment of Internal Medicine, Daegu Fatima Hospital, Daegu, South KoreaDepartment of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South KoreaDivision of Infectious Diseases, Department of Internal Medicine, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, South KoreaDepartment of Laboratory Medicine, College of Medicine, Hanyang University, Seoul, South KoreaSeegene Medical Foundation, Seoul, South KoreaDepartment of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, South KoreaDepartment of Laboratory Medicine, College of Medicine, Hanyang University, Seoul, South KoreaDepartment of Internal Medicine, College of Medicine, Hanyang University, Seoul, South Korea; Corresponding author. Department of Internal Medicine, Hanyang University College of Medicine, 222-1, Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. Fax: +82 2 2298 9183.Purpose: This study aimed to examine the changes in the characteristics of community-onset fluoroquinolone-resistant (FQ-R) Escherichia coli isolates causing community-acquired acute pyelonephritis (APN) in South Korea. Methods: Blood or urine samples were prospectively collected from patients aged ≥15 years with community-acquired APN who were admitted to one of the eight Korean hospitals included in this study between September 2017 and August 2018. Phylogenetic typing, multilocus sequence typing, and molecular characterization of β-lactamase resistance and plasmid-mediated quinolone resistance (PMQR) determinants were performed. The data were compared with those from a previous study with the same design conducted in 2010–2011. Results: A total of 300 and 346 isolates were identified in 2010–2011 and 2017–2018, respectively. Among them, 76 (22.0%) and 77 (25.7%) FQ-R isolates were identified in 2010–2011 and 2017–2018, respectively. A significantly higher antimicrobial resistance against third-to fourth-generation cephalosporins, including cefotaxime (23.9% vs. 77.9%, P < 0.001), were observed among FQ-R isolates in 2017–2018 than among those in 2010–2011. A higher proportion of ST131 isolates (27.6% vs. 66.2%, P < 0.001), as well as isolates that had extended-spectrum β-lactamase (ESBL)/plasmid-mediated AmpC β-lactamase (PABL) (23.7% vs. 79.2%, P < 0.001), was observed in 2017–2018 than in 2010–2011. Further, more PMQR determinants (11.8% vs. 40.8%, P < 0.001) were observed in 2017–2018 than in 2010–2011. Conclusions: Among uropathogenic FQ-R E. coli isolates in South Korea, the prevalence of ST131 and the proportion of isolates containing ESBL and/or PMQR determinants have increased.http://www.sciencedirect.com/science/article/pii/S1684118222000020Urinary tract infectionEscherichia coliAntimicrobial resistanceST131Korea |
| spellingShingle | Bongyoung Kim Jeoungyeon Kim Hyun-uk Jo Ki Tae Kwon Seong-yeol Ryu Seong-Heon Wie Jieun Kim Se Yoon Park Kyung-Wook Hong Hye In Kim Hyun ah Kim Mi-Hee Kim Mi Hyun Bae Yong-Hak Sohn Jieun Kim Yangsoon Lee Hyunjoo Pai Changes in the characteristics of community-onset fluoroquinolone-resistant Escherichia coli isolates causing community-acquired acute pyelonephritis in South Korea Journal of Microbiology, Immunology and Infection Urinary tract infection Escherichia coli Antimicrobial resistance ST131 Korea |
| title | Changes in the characteristics of community-onset fluoroquinolone-resistant Escherichia coli isolates causing community-acquired acute pyelonephritis in South Korea |
| title_full | Changes in the characteristics of community-onset fluoroquinolone-resistant Escherichia coli isolates causing community-acquired acute pyelonephritis in South Korea |
| title_fullStr | Changes in the characteristics of community-onset fluoroquinolone-resistant Escherichia coli isolates causing community-acquired acute pyelonephritis in South Korea |
| title_full_unstemmed | Changes in the characteristics of community-onset fluoroquinolone-resistant Escherichia coli isolates causing community-acquired acute pyelonephritis in South Korea |
| title_short | Changes in the characteristics of community-onset fluoroquinolone-resistant Escherichia coli isolates causing community-acquired acute pyelonephritis in South Korea |
| title_sort | changes in the characteristics of community onset fluoroquinolone resistant escherichia coli isolates causing community acquired acute pyelonephritis in south korea |
| topic | Urinary tract infection Escherichia coli Antimicrobial resistance ST131 Korea |
| url | http://www.sciencedirect.com/science/article/pii/S1684118222000020 |
| work_keys_str_mv | AT bongyoungkim changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT jeoungyeonkim changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT hyunukjo changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT kitaekwon changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT seongyeolryu changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT seongheonwie changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT jieunkim changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT seyoonpark changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT kyungwookhong changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT hyeinkim changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT hyunahkim changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT miheekim changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT mihyunbae changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT yonghaksohn changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT jieunkim changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT yangsoonlee changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea AT hyunjoopai changesinthecharacteristicsofcommunityonsetfluoroquinoloneresistantescherichiacoliisolatescausingcommunityacquiredacutepyelonephritisinsouthkorea |