Increased MARCKS Activity in BRAF Inhibitor-Resistant Melanoma Cells Is Essential for Their Enhanced Metastatic Behavior Independent of Elevated WNT5A and IL-6 Signaling

Increased MARCKS Activity in BRAF Inhibitor-Resistant Melanoma Cells Is Essential for Their Enhanced Metastatic Behavior Independent of Elevated WNT5A and IL-6 Signaling

Treatment of melanoma with a BRAF inhibitor (BRAFi) frequently initiates development of BRAFi resistance, leading to increased tumor progression and metastasis. Previously, we showed that combined inhibition of elevated WNT5A and IL-6 signaling reduced the invasion and migration of BRAFi-resistant (...

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Bibliographic Details
Main Authors: Vikas Yadav, Njainday Jobe, Shakti Ranjan Satapathy, Purusottam Mohapatra, Tommy Andersson
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cancers
Subjects:
melanoma
BRAF inhibitor resistance
WNT5A
MARCKS
metastasis
Online Access:https://www.mdpi.com/2072-6694/14/24/6077

Internet

https://www.mdpi.com/2072-6694/14/24/6077

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