Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk
Non-alcoholic fatty liver disease is associated with an increased risk of metabolic and cardiovascular diseases. Whether the severity of fatty liver on ultrasound correlates with metabolic or cardiovascular risk remains unclear. A total of 1000 people receiving health examinations were enrolled, and...
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| Format: | Article |
| Language: | English |
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Wiley
2012-03-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X11002282 |
| _version_ | 1819150138493370368 |
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| author | Chia-Chi Wang Tai-Chung Tseng Tsung-Cheng Hsieh Ching-Sheng Hsu Pin-Chao Wang Hans Hsienhong Lin Jia-Horng Kao |
| author_facet | Chia-Chi Wang Tai-Chung Tseng Tsung-Cheng Hsieh Ching-Sheng Hsu Pin-Chao Wang Hans Hsienhong Lin Jia-Horng Kao |
| author_sort | Chia-Chi Wang |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease is associated with an increased risk of metabolic and cardiovascular diseases. Whether the severity of fatty liver on ultrasound correlates with metabolic or cardiovascular risk remains unclear. A total of 1000 people receiving health examinations were enrolled, and 126 were excluded due to the presence of HBsAg, anti-HCV, known hepatic disorders or alcohol use (>140 g/wk). Significant fatty liver consisted of moderate and severe fatty liver on ultrasound. The definition of central obesity was modified to a waist circumference of >90 cm in men and >80 cm in women. Framingham risk score was used to estimate the risk of cardiovascular disease. A total of 874 subjects (485 women and 388 men with a mean age of 52.07 ± 11.68 years) were included in the final analysis. By using logistic regression analyses stratified by gender, the odds ratio for the prevalence of diabetes mellitus, metabolic syndrome and risk of cardiovascular disease increased with increasing fatty liver status in both genders (p ≤ 0.001). The difference was not only present between individuals with fatty liver vs. non-fatty liver but also between the mild fatty liver and significant fatty liver groups (p < 0.05). In conclusion, the severity of fatty liver on ultrasound could be useful for the risk stratification of metabolic syndrome, diabetes mellitus and cardiovascular disease in clinical practice. |
| first_indexed | 2024-12-22T14:12:44Z |
| format | Article |
| id | doaj.art-b6e1b4411f5f4c0da275a4fb3aa88333 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-22T14:12:44Z |
| publishDate | 2012-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-b6e1b4411f5f4c0da275a4fb3aa883332022-12-21T18:23:10ZengWileyKaohsiung Journal of Medical Sciences1607-551X2012-03-0128315116010.1016/j.kjms.2011.10.005Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular riskChia-Chi Wang0Tai-Chung Tseng1Tsung-Cheng Hsieh2Ching-Sheng Hsu3Pin-Chao Wang4Hans Hsienhong Lin5Jia-Horng Kao6Department of Hepatology, Buddhist Tzu Chi General Hospital, Taipei Branch and School of Medicine, Tzu Chi University, Hualien, TaiwanDepartment of Hepatology, Buddhist Tzu Chi General Hospital, Taipei Branch and School of Medicine, Tzu Chi University, Hualien, TaiwanInstitute of Medical Sciences, Tzu Chi University, Hualien, TaiwanDepartment of Hepatology, Buddhist Tzu Chi General Hospital, Taipei Branch and School of Medicine, Tzu Chi University, Hualien, TaiwanDepartment of Hepatology, Buddhist Tzu Chi General Hospital, Taipei Branch and School of Medicine, Tzu Chi University, Hualien, TaiwanDepartment of Hepatology, Buddhist Tzu Chi General Hospital, Taipei Branch and School of Medicine, Tzu Chi University, Hualien, TaiwanGraduate Institute of Clinical Medicine and Hepatitis Research Center, National Taiwan University College of Medicine and Hospital, TaiwanNon-alcoholic fatty liver disease is associated with an increased risk of metabolic and cardiovascular diseases. Whether the severity of fatty liver on ultrasound correlates with metabolic or cardiovascular risk remains unclear. A total of 1000 people receiving health examinations were enrolled, and 126 were excluded due to the presence of HBsAg, anti-HCV, known hepatic disorders or alcohol use (>140 g/wk). Significant fatty liver consisted of moderate and severe fatty liver on ultrasound. The definition of central obesity was modified to a waist circumference of >90 cm in men and >80 cm in women. Framingham risk score was used to estimate the risk of cardiovascular disease. A total of 874 subjects (485 women and 388 men with a mean age of 52.07 ± 11.68 years) were included in the final analysis. By using logistic regression analyses stratified by gender, the odds ratio for the prevalence of diabetes mellitus, metabolic syndrome and risk of cardiovascular disease increased with increasing fatty liver status in both genders (p ≤ 0.001). The difference was not only present between individuals with fatty liver vs. non-fatty liver but also between the mild fatty liver and significant fatty liver groups (p < 0.05). In conclusion, the severity of fatty liver on ultrasound could be useful for the risk stratification of metabolic syndrome, diabetes mellitus and cardiovascular disease in clinical practice.http://www.sciencedirect.com/science/article/pii/S1607551X11002282Cardiovascular diseaseDiabetes mellitusNon-alcoholic fatty liver disease (NAFLD)Metabolic syndromeUltrasound |
| spellingShingle | Chia-Chi Wang Tai-Chung Tseng Tsung-Cheng Hsieh Ching-Sheng Hsu Pin-Chao Wang Hans Hsienhong Lin Jia-Horng Kao Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk Kaohsiung Journal of Medical Sciences Cardiovascular disease Diabetes mellitus Non-alcoholic fatty liver disease (NAFLD) Metabolic syndrome Ultrasound |
| title | Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk |
| title_full | Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk |
| title_fullStr | Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk |
| title_full_unstemmed | Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk |
| title_short | Severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk |
| title_sort | severity of fatty liver on ultrasound correlates with metabolic and cardiovascular risk |
| topic | Cardiovascular disease Diabetes mellitus Non-alcoholic fatty liver disease (NAFLD) Metabolic syndrome Ultrasound |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X11002282 |
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