Assessment of the association between diabetes mellitus and chronic kidney disease in adult cats
Abstract Background Diabetes mellitus is the main cause of chronic kidney disease (CKD) in humans. The relationship between the 2 diseases in cats is unclear. Objective To assess the association between diabetes and CKD in a population of adult cats. Animals Five hundred sixty‐one cats that attended...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-09-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.15559 |
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| author | Laura Pérez‐López Mauro Boronat Carlos Melián Pedro Saavedra Yeray Brito‐Casillas Ana M. Wägner |
| author_facet | Laura Pérez‐López Mauro Boronat Carlos Melián Pedro Saavedra Yeray Brito‐Casillas Ana M. Wägner |
| author_sort | Laura Pérez‐López |
| collection | DOAJ |
| description | Abstract Background Diabetes mellitus is the main cause of chronic kidney disease (CKD) in humans. The relationship between the 2 diseases in cats is unclear. Objective To assess the association between diabetes and CKD in a population of adult cats. Animals Five hundred sixty‐one cats that attended 2 veterinary centers in Gran Canaria, Spain, between 2014 and 2016. Methods Medical records were retrospectively reviewed. Cats aged 3 years or older, with sufficient data to define whether or not they had diabetes and CKD, were selected. Cats in critical condition, with dehydration or potential causes of prerenal azotemia and those treated with nephrotoxic drugs were excluded. Diagnosis of CKD was established when creatinine concentrations were >2 mg/dL, or serum creatinine 1.6‐2 mg/dL and urine specific gravity <1.035, or serum creatinine 1.6‐2 mg/dL and urine protein/creatinine ratio >0.4. Factors associated with CKD were identified through multivariate logistic regression analyses. Results Sixty‐seven (11.9%) cats had CKD and 16 (2.9%) cats had diabetes. Sixty cats without diabetes (11%) and 7 with diabetes (44%) had CKD. Among the latter, both conditions were diagnosed simultaneously in 6 cases, whereas diabetes preceded CKD in the other. Multivariate analysis showed that diabetes was significantly associated with CKD (odds ratio = 4.47; 95% confidence interval, 1.51‐13.28; P = .007). Other variables associated with CKD were age and mixed breed. Conclusions and Clinical Importance After adjusting for age, this study showed an association between diabetes and CKD in adult cats. |
| first_indexed | 2024-04-12T16:16:47Z |
| format | Article |
| id | doaj.art-b6e366b96da34645a739505454c4a4af |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-12T16:16:47Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-b6e366b96da34645a739505454c4a4af2022-12-22T03:25:42ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762019-09-013351921192510.1111/jvim.15559Assessment of the association between diabetes mellitus and chronic kidney disease in adult catsLaura Pérez‐López0Mauro Boronat1Carlos Melián2Pedro Saavedra3Yeray Brito‐Casillas4Ana M. Wägner5Institute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC) Las Palmas de Gran Canaria SpainInstitute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC) Las Palmas de Gran Canaria SpainInstitute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC) Las Palmas de Gran Canaria SpainMathematics Department of the University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria SpainInstitute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC) Las Palmas de Gran Canaria SpainInstitute of Biomedical and Health Research (IUIBS), University of Las Palmas de Gran Canaria (ULPGC) Las Palmas de Gran Canaria SpainAbstract Background Diabetes mellitus is the main cause of chronic kidney disease (CKD) in humans. The relationship between the 2 diseases in cats is unclear. Objective To assess the association between diabetes and CKD in a population of adult cats. Animals Five hundred sixty‐one cats that attended 2 veterinary centers in Gran Canaria, Spain, between 2014 and 2016. Methods Medical records were retrospectively reviewed. Cats aged 3 years or older, with sufficient data to define whether or not they had diabetes and CKD, were selected. Cats in critical condition, with dehydration or potential causes of prerenal azotemia and those treated with nephrotoxic drugs were excluded. Diagnosis of CKD was established when creatinine concentrations were >2 mg/dL, or serum creatinine 1.6‐2 mg/dL and urine specific gravity <1.035, or serum creatinine 1.6‐2 mg/dL and urine protein/creatinine ratio >0.4. Factors associated with CKD were identified through multivariate logistic regression analyses. Results Sixty‐seven (11.9%) cats had CKD and 16 (2.9%) cats had diabetes. Sixty cats without diabetes (11%) and 7 with diabetes (44%) had CKD. Among the latter, both conditions were diagnosed simultaneously in 6 cases, whereas diabetes preceded CKD in the other. Multivariate analysis showed that diabetes was significantly associated with CKD (odds ratio = 4.47; 95% confidence interval, 1.51‐13.28; P = .007). Other variables associated with CKD were age and mixed breed. Conclusions and Clinical Importance After adjusting for age, this study showed an association between diabetes and CKD in adult cats.https://doi.org/10.1111/jvim.15559creatininefelineglucosenephropathy |
| spellingShingle | Laura Pérez‐López Mauro Boronat Carlos Melián Pedro Saavedra Yeray Brito‐Casillas Ana M. Wägner Assessment of the association between diabetes mellitus and chronic kidney disease in adult cats Journal of Veterinary Internal Medicine creatinine feline glucose nephropathy |
| title | Assessment of the association between diabetes mellitus and chronic kidney disease in adult cats |
| title_full | Assessment of the association between diabetes mellitus and chronic kidney disease in adult cats |
| title_fullStr | Assessment of the association between diabetes mellitus and chronic kidney disease in adult cats |
| title_full_unstemmed | Assessment of the association between diabetes mellitus and chronic kidney disease in adult cats |
| title_short | Assessment of the association between diabetes mellitus and chronic kidney disease in adult cats |
| title_sort | assessment of the association between diabetes mellitus and chronic kidney disease in adult cats |
| topic | creatinine feline glucose nephropathy |
| url | https://doi.org/10.1111/jvim.15559 |
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