Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia
Abstract Currently, antibiotic-resistant bacterial infections are a challenge for the health care system. Although physicians demand timely drug resistance data to guide empirical treatment, local data is rather scarce. Hence, this study performed a retrospective analysis of microbiological findings...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-99272-2 |
| _version_ | 1818398620878110720 |
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| author | Mengistu Hailemariam Tsegaye Alemayehu Bereket Tadesse Netsanete Nigussie Asnakech Agegnehu Techilo Habtemariam Mulubrhan Ali Enkosilassie Mitiku Elshaday Azerefegne |
| author_facet | Mengistu Hailemariam Tsegaye Alemayehu Bereket Tadesse Netsanete Nigussie Asnakech Agegnehu Techilo Habtemariam Mulubrhan Ali Enkosilassie Mitiku Elshaday Azerefegne |
| author_sort | Mengistu Hailemariam |
| collection | DOAJ |
| description | Abstract Currently, antibiotic-resistant bacterial infections are a challenge for the health care system. Although physicians demand timely drug resistance data to guide empirical treatment, local data is rather scarce. Hence, this study performed a retrospective analysis of microbiological findings at the Hawassa public hospital. Secondary data were retrieved to assess the prevalence and level of drug resistance for the most common bacterial isolates from clinical samples processed at Hawassa University Comprehensive Specialized Hospital. Out of 1085 clinical samples processed in the microbiology laboratory, the prevalence of bacterial infection was 32.6%. Bacterial bloodstream infection was higher in children than in adults (OR, 4; 95% CI 1.8–14.6; p = 0.005). E. coli and K. pneumoniae were the commonest bacterial isolate both in children (36.8%, 26.3%) and in adults (33.3%, 26.7%) from the urine sample while, the leading bacteria identified from the CSF sample was P. aeruginosa, 37% in children and 43% in adult. In this study, all identified bacterial isolates were multi-drug resistant (MDR) ranging from 50 to 91%. The highest proportion of MDR was S. aureus 91.1 followed by K. pneumoniae 87.6%. Since the nationwide investigation of bacterial isolate, and drug resistance is rare in Ethiopia, a report from such type of local surveillance is highly useful to guide empirical therapy by providing awareness on the level resistance of isolates. |
| first_indexed | 2024-12-14T07:07:41Z |
| format | Article |
| id | doaj.art-b6e60bc99d5e4d38ac65a1838d1fd9a2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T07:07:41Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b6e60bc99d5e4d38ac65a1838d1fd9a22022-12-21T23:12:06ZengNature PortfolioScientific Reports2045-23222021-10-011111910.1038/s41598-021-99272-2Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern EthiopiaMengistu Hailemariam0Tsegaye Alemayehu1Bereket Tadesse2Netsanete Nigussie3Asnakech Agegnehu4Techilo Habtemariam5Mulubrhan Ali6Enkosilassie Mitiku7Elshaday Azerefegne8School of Medical Laboratory Science, Hawassa University College of Medicine and Health SciencesSchool of Medical Laboratory Science, Hawassa University College of Medicine and Health SciencesHawassa University Comprehensive and Specialized HospitalHawassa University Comprehensive and Specialized HospitalHawassa University Comprehensive and Specialized HospitalHawassa University Comprehensive and Specialized HospitalSchool of Medical Laboratory Science, Hawassa University College of Medicine and Health SciencesHawassa University Comprehensive and Specialized HospitalHawassa University Comprehensive and Specialized HospitalAbstract Currently, antibiotic-resistant bacterial infections are a challenge for the health care system. Although physicians demand timely drug resistance data to guide empirical treatment, local data is rather scarce. Hence, this study performed a retrospective analysis of microbiological findings at the Hawassa public hospital. Secondary data were retrieved to assess the prevalence and level of drug resistance for the most common bacterial isolates from clinical samples processed at Hawassa University Comprehensive Specialized Hospital. Out of 1085 clinical samples processed in the microbiology laboratory, the prevalence of bacterial infection was 32.6%. Bacterial bloodstream infection was higher in children than in adults (OR, 4; 95% CI 1.8–14.6; p = 0.005). E. coli and K. pneumoniae were the commonest bacterial isolate both in children (36.8%, 26.3%) and in adults (33.3%, 26.7%) from the urine sample while, the leading bacteria identified from the CSF sample was P. aeruginosa, 37% in children and 43% in adult. In this study, all identified bacterial isolates were multi-drug resistant (MDR) ranging from 50 to 91%. The highest proportion of MDR was S. aureus 91.1 followed by K. pneumoniae 87.6%. Since the nationwide investigation of bacterial isolate, and drug resistance is rare in Ethiopia, a report from such type of local surveillance is highly useful to guide empirical therapy by providing awareness on the level resistance of isolates.https://doi.org/10.1038/s41598-021-99272-2 |
| spellingShingle | Mengistu Hailemariam Tsegaye Alemayehu Bereket Tadesse Netsanete Nigussie Asnakech Agegnehu Techilo Habtemariam Mulubrhan Ali Enkosilassie Mitiku Elshaday Azerefegne Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia Scientific Reports |
| title | Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia |
| title_full | Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia |
| title_fullStr | Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia |
| title_full_unstemmed | Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia |
| title_short | Major bacterial isolate and antibiotic resistance from routine clinical samples in Southern Ethiopia |
| title_sort | major bacterial isolate and antibiotic resistance from routine clinical samples in southern ethiopia |
| url | https://doi.org/10.1038/s41598-021-99272-2 |
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