Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats
Cigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.737204/full |
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| author | Xiang Wang Xiang Wang Pei Ye Li Fang Sheng Ge Fan Huang Peter J. Polverini Weiwei Heng Lichun Zheng Qingang Hu Fuhua Yan Wenmei Wang |
| author_facet | Xiang Wang Xiang Wang Pei Ye Li Fang Sheng Ge Fan Huang Peter J. Polverini Weiwei Heng Lichun Zheng Qingang Hu Fuhua Yan Wenmei Wang |
| author_sort | Xiang Wang |
| collection | DOAJ |
| description | Cigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investigated. Here, we developed a rat model of active smoking and characterized the effects of active smoking on the microbiota within multiple regions along the digestive tract. Blood glucose and some metabolic factors levels, the microbial diversity and composition, relative abundances of taxa, bacterial network correlations and predictive functional profiles were compared between the control group and active smoking group. We found that active smoking induced hyperglycemia and significant reductions in serum insulin and leptin levels. Active smoking induced region-specific shifts in microbiota structure, composition, network correlation and metabolism function along the digestive tract. Our results demonstrated that active smoking resulted in a reduced abundance of some potentially beneficial genera (i.e. Clostridium, Turicibacter) and increased abundance of potentially harmful genera (i.e. Desulfovibrio, Bilophila). Functional prediction suggested that amino acid, lipid, propanoate metabolism function could be impaired and antioxidant activity may be triggered. Active smoking may be an overlooked risk to health through its potential effects on the digestive tract microbiota, which is involved in the cause and severity of an array of chronic diseases. |
| first_indexed | 2024-12-21T09:58:07Z |
| format | Article |
| id | doaj.art-b6e731baef0c47a78b5b6694b4df3fec |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-21T09:58:07Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-b6e731baef0c47a78b5b6694b4df3fec2022-12-21T19:08:00ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-11-011110.3389/fcimb.2021.737204737204Active Smoking Induces Aberrations in Digestive Tract Microbiota of RatsXiang Wang0Xiang Wang1Pei Ye2Li Fang3Sheng Ge4Fan Huang5Peter J. Polverini6Weiwei Heng7Lichun Zheng8Qingang Hu9Fuhua Yan10Wenmei Wang11Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, United StatesNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, United StatesNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaCigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investigated. Here, we developed a rat model of active smoking and characterized the effects of active smoking on the microbiota within multiple regions along the digestive tract. Blood glucose and some metabolic factors levels, the microbial diversity and composition, relative abundances of taxa, bacterial network correlations and predictive functional profiles were compared between the control group and active smoking group. We found that active smoking induced hyperglycemia and significant reductions in serum insulin and leptin levels. Active smoking induced region-specific shifts in microbiota structure, composition, network correlation and metabolism function along the digestive tract. Our results demonstrated that active smoking resulted in a reduced abundance of some potentially beneficial genera (i.e. Clostridium, Turicibacter) and increased abundance of potentially harmful genera (i.e. Desulfovibrio, Bilophila). Functional prediction suggested that amino acid, lipid, propanoate metabolism function could be impaired and antioxidant activity may be triggered. Active smoking may be an overlooked risk to health through its potential effects on the digestive tract microbiota, which is involved in the cause and severity of an array of chronic diseases.https://www.frontiersin.org/articles/10.3389/fcimb.2021.737204/fullsmokingmicrobiotadigestive tractgastrointestinal tractoral cavity |
| spellingShingle | Xiang Wang Xiang Wang Pei Ye Li Fang Sheng Ge Fan Huang Peter J. Polverini Weiwei Heng Lichun Zheng Qingang Hu Fuhua Yan Wenmei Wang Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats Frontiers in Cellular and Infection Microbiology smoking microbiota digestive tract gastrointestinal tract oral cavity |
| title | Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats |
| title_full | Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats |
| title_fullStr | Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats |
| title_full_unstemmed | Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats |
| title_short | Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats |
| title_sort | active smoking induces aberrations in digestive tract microbiota of rats |
| topic | smoking microbiota digestive tract gastrointestinal tract oral cavity |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.737204/full |
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