A Novel Approach towards Synthesis and Characterization of Non-Cytotoxic Gold Nanoparticles Using Taurine as Capping Agent
Metal gold nanoparticles are of great interest due to their unique physico-chemical properties and their potential to be used as nano-probes in biosensors, drug delivery, and therapeutic applications. Currently, many capping agents are used for metal gold nanoparticles, such as cetyltrimethylammoniu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-12-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/1/45 |
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| author | Akash Kumar Nabojit Das Neeraj Kumar Satija Kapil Mandrah Somendu Kumar Roy Raja Gopal Rayavarapu |
| author_facet | Akash Kumar Nabojit Das Neeraj Kumar Satija Kapil Mandrah Somendu Kumar Roy Raja Gopal Rayavarapu |
| author_sort | Akash Kumar |
| collection | DOAJ |
| description | Metal gold nanoparticles are of great interest due to their unique physico-chemical properties and their potential to be used as nano-probes in biosensors, drug delivery, and therapeutic applications. Currently, many capping agents are used for metal gold nanoparticles, such as cetyltrimethylammonium bromide (CTAB) and tri-sodium citrate that have been reported to be toxic and hinders biological applications. To address this issue, we report, for the first time, the use of taurine as a stable non-cytotoxic capping agent for synthesizing gold nanoparticles by using an in situ wet-chemical method. This facile method resulted in monodisperse gold nanospheres with a high yield and stability. Monodisperse gold nanospheres with average diameters of 6.9 nm and 46 nm were synthesized at a high yield with controlled morphology. Temperature played a critical role in determining the size of the taurine-capped gold nanoparticles. The subtle changes in the reaction parameters had a tremendous effect on the final size of nanoparticles and their stability. The synthesized nanoparticles were characterized by using optical spectroscopy, a ZetaSizer, a NanoSight, Fourier Transform Infrared (FTIR) spectroscopy, X-ray Diffraction (XRD), X-ray Photon Spectroscopy (XPS) and Electron Microscopy to understand their physico-chemical properties. Taurine was explored as a capping and stabilizing agent for gold nanospheres, which were evaluated for their toxicity responses towards human liver carcinoma cells (HepG2) via MTT assay. |
| first_indexed | 2024-12-22T02:47:59Z |
| format | Article |
| id | doaj.art-b6e79efe1b444f16b3ff443828631aca |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-22T02:47:59Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-b6e79efe1b444f16b3ff443828631aca2022-12-21T18:41:27ZengMDPI AGNanomaterials2079-49912019-12-011014510.3390/nano10010045nano10010045A Novel Approach towards Synthesis and Characterization of Non-Cytotoxic Gold Nanoparticles Using Taurine as Capping AgentAkash Kumar0Nabojit Das1Neeraj Kumar Satija2Kapil Mandrah3Somendu Kumar Roy4Raja Gopal Rayavarapu5Nanomaterial Toxicology Laboratory, Nanomaterial Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow 226001, IndiaNanomaterial Toxicology Laboratory, Nanomaterial Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow 226001, IndiaAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, IndiaAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, IndiaAcademy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, IndiaNanomaterial Toxicology Laboratory, Nanomaterial Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow 226001, IndiaMetal gold nanoparticles are of great interest due to their unique physico-chemical properties and their potential to be used as nano-probes in biosensors, drug delivery, and therapeutic applications. Currently, many capping agents are used for metal gold nanoparticles, such as cetyltrimethylammonium bromide (CTAB) and tri-sodium citrate that have been reported to be toxic and hinders biological applications. To address this issue, we report, for the first time, the use of taurine as a stable non-cytotoxic capping agent for synthesizing gold nanoparticles by using an in situ wet-chemical method. This facile method resulted in monodisperse gold nanospheres with a high yield and stability. Monodisperse gold nanospheres with average diameters of 6.9 nm and 46 nm were synthesized at a high yield with controlled morphology. Temperature played a critical role in determining the size of the taurine-capped gold nanoparticles. The subtle changes in the reaction parameters had a tremendous effect on the final size of nanoparticles and their stability. The synthesized nanoparticles were characterized by using optical spectroscopy, a ZetaSizer, a NanoSight, Fourier Transform Infrared (FTIR) spectroscopy, X-ray Diffraction (XRD), X-ray Photon Spectroscopy (XPS) and Electron Microscopy to understand their physico-chemical properties. Taurine was explored as a capping and stabilizing agent for gold nanospheres, which were evaluated for their toxicity responses towards human liver carcinoma cells (HepG2) via MTT assay.https://www.mdpi.com/2079-4991/10/1/45gold nanoparticlestoxicitycapping agentsynthesistaurinecharacterization |
| spellingShingle | Akash Kumar Nabojit Das Neeraj Kumar Satija Kapil Mandrah Somendu Kumar Roy Raja Gopal Rayavarapu A Novel Approach towards Synthesis and Characterization of Non-Cytotoxic Gold Nanoparticles Using Taurine as Capping Agent Nanomaterials gold nanoparticles toxicity capping agent synthesis taurine characterization |
| title | A Novel Approach towards Synthesis and Characterization of Non-Cytotoxic Gold Nanoparticles Using Taurine as Capping Agent |
| title_full | A Novel Approach towards Synthesis and Characterization of Non-Cytotoxic Gold Nanoparticles Using Taurine as Capping Agent |
| title_fullStr | A Novel Approach towards Synthesis and Characterization of Non-Cytotoxic Gold Nanoparticles Using Taurine as Capping Agent |
| title_full_unstemmed | A Novel Approach towards Synthesis and Characterization of Non-Cytotoxic Gold Nanoparticles Using Taurine as Capping Agent |
| title_short | A Novel Approach towards Synthesis and Characterization of Non-Cytotoxic Gold Nanoparticles Using Taurine as Capping Agent |
| title_sort | novel approach towards synthesis and characterization of non cytotoxic gold nanoparticles using taurine as capping agent |
| topic | gold nanoparticles toxicity capping agent synthesis taurine characterization |
| url | https://www.mdpi.com/2079-4991/10/1/45 |
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