A case report of cerebral venous sinus thrombosis presenting with rapidly progressive dementia
BackgroundCerebral venous sinus thrombosis (CVST) is a rare but serious and treatable cause of neurologic symptoms. Due to the variable clinical presentation, CVST was often misdiagnosed. According to published case reports, common clinical manifestations of CVST include headache, focal neurological...
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Frontiers Media S.A.
2022-08-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.985361/full |
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| author | Yaqiang Li Yaqiang Li Mei Zhang Min Xue Ming Wei Jiale He Chunhui Dong |
| author_facet | Yaqiang Li Yaqiang Li Mei Zhang Min Xue Ming Wei Jiale He Chunhui Dong |
| author_sort | Yaqiang Li |
| collection | DOAJ |
| description | BackgroundCerebral venous sinus thrombosis (CVST) is a rare but serious and treatable cause of neurologic symptoms. Due to the variable clinical presentation, CVST was often misdiagnosed. According to published case reports, common clinical manifestations of CVST include headache, focal neurological deficit, epilepsy, papilledema, etc. It is rare, nevertheless, to mention cases of rapidly progressive dementia (RPD).Case presentationWe reported a case of a 62-year-old retired male accountant, a Han Chinese from eastern China, who initially presented with slow response and memory decline. Until 2 months later, his memory declined and slow response deteriorated significantly, and he could not even complete simple tasks like brushing his teeth, washing his face, washing his feet, and dressing himself, and sometimes developed fecal incontinence. His neuropsychological test demonstrated severe cognitive decline. The cerebrospinal fluid (CSF) studies revealed markedly high opening pressure (260 mm of water), and coagulation tests indicated a mild elevation of D-Dimer of 1.19 mg/L. The magnetic resonance venography (MRV) showed thrombosis of the left transverse sinus, sigmoid sinus, and jugular venous bulb and was diagnosed as CVST. He switched from subcutaneous low molecular weight heparin (LMWH) and transitioned to oral anticoagulants at the time of discharge. The repeated CSF studies revealed normal opening pressure. After 5 days of anticoagulant treatment, his symptoms considerably improved, and a 1-month follow-up revealed that he had fully healed with no signs of recurrence.ConclusionThis case demonstrated the clinical heterogeneity of CVST, which should be taken into account for differential diagnosis of RPD. This case study also offered fresh data for the categorization of the clinical traits and the diagnosis of CVST. |
| first_indexed | 2024-04-14T02:56:09Z |
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| id | doaj.art-b6e7cb38fbc4418c9b331521380d2d8f |
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| language | English |
| last_indexed | 2024-04-14T02:56:09Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-b6e7cb38fbc4418c9b331521380d2d8f2022-12-22T02:16:07ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.985361985361A case report of cerebral venous sinus thrombosis presenting with rapidly progressive dementiaYaqiang Li0Yaqiang Li1Mei Zhang2Min Xue3Ming Wei4Jiale He5Chunhui Dong6Department of Neurology, The First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan), Huainan, ChinaDepartment of Neurology, People’s Hospital of Lixin County, Bozhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan), Huainan, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan), Huainan, ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan), Huainan, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan), Huainan, ChinaDepartment of Laboratory, The First Affiliated Hospital of Anhui University of Science and Technology (First People’s Hospital of Huainan), Huainan, ChinaBackgroundCerebral venous sinus thrombosis (CVST) is a rare but serious and treatable cause of neurologic symptoms. Due to the variable clinical presentation, CVST was often misdiagnosed. According to published case reports, common clinical manifestations of CVST include headache, focal neurological deficit, epilepsy, papilledema, etc. It is rare, nevertheless, to mention cases of rapidly progressive dementia (RPD).Case presentationWe reported a case of a 62-year-old retired male accountant, a Han Chinese from eastern China, who initially presented with slow response and memory decline. Until 2 months later, his memory declined and slow response deteriorated significantly, and he could not even complete simple tasks like brushing his teeth, washing his face, washing his feet, and dressing himself, and sometimes developed fecal incontinence. His neuropsychological test demonstrated severe cognitive decline. The cerebrospinal fluid (CSF) studies revealed markedly high opening pressure (260 mm of water), and coagulation tests indicated a mild elevation of D-Dimer of 1.19 mg/L. The magnetic resonance venography (MRV) showed thrombosis of the left transverse sinus, sigmoid sinus, and jugular venous bulb and was diagnosed as CVST. He switched from subcutaneous low molecular weight heparin (LMWH) and transitioned to oral anticoagulants at the time of discharge. The repeated CSF studies revealed normal opening pressure. After 5 days of anticoagulant treatment, his symptoms considerably improved, and a 1-month follow-up revealed that he had fully healed with no signs of recurrence.ConclusionThis case demonstrated the clinical heterogeneity of CVST, which should be taken into account for differential diagnosis of RPD. This case study also offered fresh data for the categorization of the clinical traits and the diagnosis of CVST.https://www.frontiersin.org/articles/10.3389/fmed.2022.985361/fullcerebral venous sinus thrombosis (CVST)dementiarapidly progressive dementiaidiopathic intracranial hypertension (IIH)anticoagulant |
| spellingShingle | Yaqiang Li Yaqiang Li Mei Zhang Min Xue Ming Wei Jiale He Chunhui Dong A case report of cerebral venous sinus thrombosis presenting with rapidly progressive dementia Frontiers in Medicine cerebral venous sinus thrombosis (CVST) dementia rapidly progressive dementia idiopathic intracranial hypertension (IIH) anticoagulant |
| title | A case report of cerebral venous sinus thrombosis presenting with rapidly progressive dementia |
| title_full | A case report of cerebral venous sinus thrombosis presenting with rapidly progressive dementia |
| title_fullStr | A case report of cerebral venous sinus thrombosis presenting with rapidly progressive dementia |
| title_full_unstemmed | A case report of cerebral venous sinus thrombosis presenting with rapidly progressive dementia |
| title_short | A case report of cerebral venous sinus thrombosis presenting with rapidly progressive dementia |
| title_sort | case report of cerebral venous sinus thrombosis presenting with rapidly progressive dementia |
| topic | cerebral venous sinus thrombosis (CVST) dementia rapidly progressive dementia idiopathic intracranial hypertension (IIH) anticoagulant |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.985361/full |
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