Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)
To define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (C...
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MDPI AG
2023-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/17/5738 |
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| author | Anna Winter Stefan M. Schulz Marc Schmitter Urs Müller-Richter Alexander Kübler Sylvia Kasper Stefan Hartmann |
| author_facet | Anna Winter Stefan M. Schulz Marc Schmitter Urs Müller-Richter Alexander Kübler Sylvia Kasper Stefan Hartmann |
| author_sort | Anna Winter |
| collection | DOAJ |
| description | To define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (CGA) was performed on 21 r/m HNSCC patients at two defined assessments, and the QoL aspects and the impact of descriptive data were evaluated. The Kolmogorov–Smirnov test, Spearman’s rho correlation, and two-way mixed ANOVA were used for statistical analysis. All patients were found to be “frail”. Pain, fatigue, and the burden of illness were the highest-rated symptoms. Oral function and orofacial appearance were highly impaired. A significant impact of descriptive data on the CGA and QoL results was found (all <i>p</i> ≤ 0.05). Thus, the CGA results revealed high frailty, severe comorbidities, and high impairments in QoL aspects. The CGA and QoL results were negatively affected by the primary HNSCC treatment approach, the need for prosthetic treatment, and worse oral functional capacity. Therefore, frailty in r/m HNSCC patients seems to be multidimensional. The evaluation of the CGA and QoL aspects in r/m HNSCC patients can be recommended to detect special needs, organize aftercare, and improve the support for frail and vulnerable cancer patients to create a multidisciplinary treatment approach. |
| first_indexed | 2024-03-10T23:19:47Z |
| format | Article |
| id | doaj.art-b6e91d8632cc40a28f860f40c0bf170f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:19:47Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b6e91d8632cc40a28f860f40c0bf170f2023-11-19T08:24:42ZengMDPI AGJournal of Clinical Medicine2077-03832023-09-011217573810.3390/jcm12175738Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)Anna Winter0Stefan M. Schulz1Marc Schmitter2Urs Müller-Richter3Alexander Kübler4Sylvia Kasper5Stefan Hartmann6Department of Prosthodontics, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, GermanyFaculty I, Nursing Science, Department of Behavioural Medicine and Principles of Human Biology for the Health Sciences, Trier University, Universitätsring 15, 54296 Trier, GermanyDepartment of Prosthodontics, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, GermanyDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, GermanyDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, GermanyDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, GermanyDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, GermanyTo define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (CGA) was performed on 21 r/m HNSCC patients at two defined assessments, and the QoL aspects and the impact of descriptive data were evaluated. The Kolmogorov–Smirnov test, Spearman’s rho correlation, and two-way mixed ANOVA were used for statistical analysis. All patients were found to be “frail”. Pain, fatigue, and the burden of illness were the highest-rated symptoms. Oral function and orofacial appearance were highly impaired. A significant impact of descriptive data on the CGA and QoL results was found (all <i>p</i> ≤ 0.05). Thus, the CGA results revealed high frailty, severe comorbidities, and high impairments in QoL aspects. The CGA and QoL results were negatively affected by the primary HNSCC treatment approach, the need for prosthetic treatment, and worse oral functional capacity. Therefore, frailty in r/m HNSCC patients seems to be multidimensional. The evaluation of the CGA and QoL aspects in r/m HNSCC patients can be recommended to detect special needs, organize aftercare, and improve the support for frail and vulnerable cancer patients to create a multidisciplinary treatment approach.https://www.mdpi.com/2077-0383/12/17/5738frailtygeriatric cancer patientrecurrent/metastatic head and neck squamous cell carcinomaoral health-related quality of lifeprosthetic rehabilitationoral functional capacity |
| spellingShingle | Anna Winter Stefan M. Schulz Marc Schmitter Urs Müller-Richter Alexander Kübler Sylvia Kasper Stefan Hartmann Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) Journal of Clinical Medicine frailty geriatric cancer patient recurrent/metastatic head and neck squamous cell carcinoma oral health-related quality of life prosthetic rehabilitation oral functional capacity |
| title | Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) |
| title_full | Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) |
| title_fullStr | Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) |
| title_full_unstemmed | Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) |
| title_short | Comprehensive Geriatric Assessment and Quality of Life Aspects in Patients with Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) |
| title_sort | comprehensive geriatric assessment and quality of life aspects in patients with recurrent metastatic head and neck squamous cell carcinoma hnscc |
| topic | frailty geriatric cancer patient recurrent/metastatic head and neck squamous cell carcinoma oral health-related quality of life prosthetic rehabilitation oral functional capacity |
| url | https://www.mdpi.com/2077-0383/12/17/5738 |
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