Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys
Objective: Alteration of the antioxidant status in the kidneys may be related to lead (Pb) intoxication. The present study aimed to investigate the possible beneficial effect of thymoquinone (TQ), the major active ingredient of the volatile oil of Nigella sativa seeds, on Pb-induced renal antioxidan...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2016-04-01
|
| Series: | Libyan Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.libyanjournalofmedicine.net/index.php/ljm/article/view/31018/45866 |
| _version_ | 1818515668403748864 |
|---|---|
| author | Aymen Mabrouk Hassen Ben Cheikh |
| author_facet | Aymen Mabrouk Hassen Ben Cheikh |
| author_sort | Aymen Mabrouk |
| collection | DOAJ |
| description | Objective: Alteration of the antioxidant status in the kidneys may be related to lead (Pb) intoxication. The present study aimed to investigate the possible beneficial effect of thymoquinone (TQ), the major active ingredient of the volatile oil of Nigella sativa seeds, on Pb-induced renal antioxidant defense system impairment. Methods: A total of thirty two healthy adult male Wistar rats were randomly divided into four equal groups as follows: a control group, which received no treatment; a Pb group, which was exposed to 2,000 ppm of Pb acetate in drinking water; a Pb-TQ group, which was cotreated with Pb plus TQ (5 mg/kg/day, per os); and a TQ group receiving only TQ. All treatments were applied for five weeks. Results: TQ alone did not induce any significant changes in the antioxidant defense system. By contrast, Pb exposure significantly decreased reduced glutathione level and superoxide dismutase, glutathione peroxidase, catalase, and glutathione reductase activities in the renal tissue. Interestingly, supplementation with TQ significantly improved the affected antioxidant parameters. Conclusion: Our data are the first to provide evidence on the protective effect of TQ against Pb-induced renal antioxidant capacity impairment and suggest that this component might be a clinically promising alternative in Pb nephrotoxicity. |
| first_indexed | 2024-12-11T00:31:47Z |
| format | Article |
| id | doaj.art-b6e9269fdb7f4e2f9902d92187ee6d8e |
| institution | Directory Open Access Journal |
| issn | 1819-6357 |
| language | English |
| last_indexed | 2024-12-11T00:31:47Z |
| publishDate | 2016-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Libyan Journal of Medicine |
| spelling | doaj.art-b6e9269fdb7f4e2f9902d92187ee6d8e2022-12-22T01:27:19ZengTaylor & Francis GroupLibyan Journal of Medicine1819-63572016-04-011101510.3402/ljm.v11.3101831018Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneysAymen Mabrouk0Hassen Ben Cheikh1Laboratory of Histology and Cytogenetic (Research Unit of Genetic, Genotoxicity and Childhood Illness UR12ES10), Faculty of Medicine of Monastir, University of Monastir, Monastir, TunisiaLaboratory of Histology and Cytogenetic (Research Unit of Genetic, Genotoxicity and Childhood Illness UR12ES10), Faculty of Medicine of Monastir, University of Monastir, Monastir, TunisiaObjective: Alteration of the antioxidant status in the kidneys may be related to lead (Pb) intoxication. The present study aimed to investigate the possible beneficial effect of thymoquinone (TQ), the major active ingredient of the volatile oil of Nigella sativa seeds, on Pb-induced renal antioxidant defense system impairment. Methods: A total of thirty two healthy adult male Wistar rats were randomly divided into four equal groups as follows: a control group, which received no treatment; a Pb group, which was exposed to 2,000 ppm of Pb acetate in drinking water; a Pb-TQ group, which was cotreated with Pb plus TQ (5 mg/kg/day, per os); and a TQ group receiving only TQ. All treatments were applied for five weeks. Results: TQ alone did not induce any significant changes in the antioxidant defense system. By contrast, Pb exposure significantly decreased reduced glutathione level and superoxide dismutase, glutathione peroxidase, catalase, and glutathione reductase activities in the renal tissue. Interestingly, supplementation with TQ significantly improved the affected antioxidant parameters. Conclusion: Our data are the first to provide evidence on the protective effect of TQ against Pb-induced renal antioxidant capacity impairment and suggest that this component might be a clinically promising alternative in Pb nephrotoxicity.http://www.libyanjournalofmedicine.net/index.php/ljm/article/view/31018/45866heavy metalsthymoquinoneantioxidant parametersnephrotoxicityrat |
| spellingShingle | Aymen Mabrouk Hassen Ben Cheikh Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys Libyan Journal of Medicine heavy metals thymoquinone antioxidant parameters nephrotoxicity rat |
| title | Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys |
| title_full | Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys |
| title_fullStr | Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys |
| title_full_unstemmed | Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys |
| title_short | Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys |
| title_sort | thymoquinone ameliorates lead induced suppression of the antioxidant system in rat kidneys |
| topic | heavy metals thymoquinone antioxidant parameters nephrotoxicity rat |
| url | http://www.libyanjournalofmedicine.net/index.php/ljm/article/view/31018/45866 |
| work_keys_str_mv | AT aymenmabrouk thymoquinoneamelioratesleadinducedsuppressionoftheantioxidantsysteminratkidneys AT hassenbencheikh thymoquinoneamelioratesleadinducedsuppressionoftheantioxidantsysteminratkidneys |