The Role of HECT E3 Ubiquitin Ligases in Colorectal Cancer

The Role of HECT E3 Ubiquitin Ligases in Colorectal Cancer

Colorectal cancer (CRC) is estimated to rank as the second reason for cancer-related deaths, and the prognosis of CRC patients remains unsatisfactory. Numerous studies on gastrointestinal cell biology have shown that the E3 ligase-mediated ubiquitination exerts key functions in the pathogenesis of C...

Full description

Bibliographic Details
Main Authors:	Aiqin Sun, Yifei Chen, Xianyan Tian, Qiong Lin
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Biomedicines
Subjects:	colorectal cancer HECT E3 ligases ubiquitination tumor promoter tumor suppressor therapeutic strategy
Online Access:	https://www.mdpi.com/2227-9059/11/2/478

Similar Items

Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer
by: Aiqin Sun, et al.
Published: (2023-02-01)

Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation
by: Gerry Melino, et al.
Published: (2019-10-01)

Emerging roles of the HECT-type E3 ubiquitin ligases in hematological malignancies
by: Vincenza Simona Delvecchio, et al.
Published: (2021-10-01)

HECT E3 Ligases: A Tale With Multiple Facets
by: Janine Weber, et al.
Published: (2019-04-01)

Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization
by: Sunil Singh, et al.
Published: (2023-09-01)

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
by: Hari B Kamadurai, et al.
Published: (2013-08-01)

The Role of HECT-Type E3 Ligase in the Development of Cardiac Disease
by: Jun Goto, et al.
Published: (2021-06-01)

HERC Ubiquitin Ligases in Cancer
by: Joan Sala-Gaston, et al.
Published: (2020-06-01)

Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5
by: Qingya Shen, et al.
Published: (2018-12-01)

Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases
by: Amira Brigui, et al.
Published: (2015-01-01)

RNF11 at the Crossroads of Protein Ubiquitination
by: Anna Mattioni, et al.
Published: (2020-11-01)

Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease
by: Andrew C. Giles, et al.
Published: (2020-04-01)

A conformational switch regulates the ubiquitin ligase HUWE1
by: Bodo Sander, et al.
Published: (2017-02-01)

The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration
by: Shanez Haouari, et al.
Published: (2022-03-01)

The Janus Face of p53-Targeting Ubiquitin Ligases
by: Qian Hao, et al.
Published: (2020-07-01)

Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer
by: Sujitha Jayaprakash, et al.
Published: (2022-10-01)

RUNX3 Meets the Ubiquitin-Proteasome System in Cancer
by: Albano Toska, et al.
Published: (2023-02-01)

Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice
by: Pavithra Suresh, et al.
Published: (2022-07-01)

The role of NEDD4 related HECT-type E3 ubiquitin ligases in defective autophagy in cancer cells: molecular mechanisms and therapeutic perspectives
by: Rui Zhang, et al.
Published: (2023-03-01)

Molecular Evolution, Neurodevelopmental Roles and Clinical Significance of HECT-Type UBE3 E3 Ubiquitin Ligases
by: Mateusz C. Ambrozkiewicz, et al.
Published: (2020-11-01)

Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1
by: Wesley O. Tucker, et al.
Published: (2018-03-01)

The Impact of the Ubiquitin System in the Pathogenesis of Squamous Cell Carcinomas
by: Veronica Gatti, et al.
Published: (2020-06-01)

New Aspects of HECT-E3 Ligases in Cell Senescence and Cell Death of Plants
by: Wei Lan, et al.
Published: (2019-11-01)

The HECT E3 Ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders
by: Asia Owais, et al.
Published: (2020-07-01)

Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases
by: Stephanie Diaz, et al.
Published: (2022-03-01)

WW Domain-Containing E3 Ubiquitin Protein Ligase 1: A Self-Disciplined Oncoprotein
by: Linghan Kuang, et al.
Published: (2021-10-01)

Editorial: E3 Ubiquitin Ligases: From Structure to Physiology
by: Julien D. F. Licchesi, et al.
Published: (2020-11-01)

Alpha Enolase 1 Ubiquitination and Degradation Mediated by <i>Ehrlichia chaffeensis</i> TRP120 Disrupts Glycolytic Flux and Promotes Infection
by: Bing Zhu, et al.
Published: (2021-07-01)

UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans
by: Komal Safdar, et al.
Published: (2016-07-01)

The roles of E3 ubiquitin ligases in cancer progression and targeted therapy
by: Chibuzo Sampson, et al.
Published: (2023-03-01)

A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1
by: Youqin Xu, et al.
Published: (2019-02-01)

How to Inactivate Human Ubiquitin E3 Ligases by Mutation
by: Cristina Garcia-Barcena, et al.
Published: (2020-02-01)

MEKK5 Interacts with and Negatively Regulates the E3 Ubiquitin Ligase NEDD4 for Mediating Lung Cancer Cell Migration
by: Aiqin Sun, et al.
Published: (2021-10-01)

Ubiquitin Ligases in Cholesterol Metabolism
by: Wei Jiang, et al.
Published: (2014-06-01)

Progress on Poxvirus E3 Ubiquitin Ligases and Adaptor Proteins
by: Haoran Cui, et al.
Published: (2021-12-01)

An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome
by: Ruyi Wang, et al.
Published: (2022-07-01)

The Role of E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe?
by: Min Zou, et al.
Published: (2021-12-01)

Caught in the act
by: Hermann-Josef Meyer, et al.
Published: (2013-08-01)

Targeting E3 ubiquitin ligases to sensitize cancer radiation therapy
by: Zan Chen, et al.
Published: (2019-09-01)

The Role of E3 Ubiquitin Ligases in Chloroplast Function
by: Katherine A. Hand, et al.
Published: (2022-08-01)