Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome
Identification of gene expression changes between healthy and diseased individuals can reveal mechanistic insights and biomarkers. Here, the authors propose a bi-directional transcriptome-wide Mendelian Randomization approach to assess causal effects between gene expression and complex traits.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25805-y |
| _version_ | 1818858419581353984 |
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| author | Eleonora Porcu Marie C. Sadler Kaido Lepik Chiara Auwerx Andrew R. Wood Antoine Weihs Maroun S. Bou Sleiman Diogo M. Ribeiro Stefania Bandinelli Toshiko Tanaka Matthias Nauck Uwe Völker Olivier Delaneau Andres Metspalu Alexander Teumer Timothy Frayling Federico A. Santoni Alexandre Reymond Zoltán Kutalik |
| author_facet | Eleonora Porcu Marie C. Sadler Kaido Lepik Chiara Auwerx Andrew R. Wood Antoine Weihs Maroun S. Bou Sleiman Diogo M. Ribeiro Stefania Bandinelli Toshiko Tanaka Matthias Nauck Uwe Völker Olivier Delaneau Andres Metspalu Alexander Teumer Timothy Frayling Federico A. Santoni Alexandre Reymond Zoltán Kutalik |
| author_sort | Eleonora Porcu |
| collection | DOAJ |
| description | Identification of gene expression changes between healthy and diseased individuals can reveal mechanistic insights and biomarkers. Here, the authors propose a bi-directional transcriptome-wide Mendelian Randomization approach to assess causal effects between gene expression and complex traits. |
| first_indexed | 2024-12-19T08:55:59Z |
| format | Article |
| id | doaj.art-b6ea07fec9aa4a9aa84d8abbe352d3b1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:55:59Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b6ea07fec9aa4a9aa84d8abbe352d3b12022-12-21T20:28:37ZengNature PortfolioNature Communications2041-17232021-09-011211910.1038/s41467-021-25805-yDifferentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptomeEleonora Porcu0Marie C. Sadler1Kaido Lepik2Chiara Auwerx3Andrew R. Wood4Antoine Weihs5Maroun S. Bou Sleiman6Diogo M. Ribeiro7Stefania Bandinelli8Toshiko Tanaka9Matthias Nauck10Uwe Völker11Olivier Delaneau12Andres Metspalu13Alexander Teumer14Timothy Frayling15Federico A. Santoni16Alexandre Reymond17Zoltán Kutalik18Center for Integrative Genomics, University of LausanneSwiss Institute of BioinformaticsInstitute of Computer Science, University of TartuCenter for Integrative Genomics, University of LausanneGenetics of Complex Traits, College of Medicine and Health, University of ExeterDepartment of Psychiatry and Psychotherapy, University Medicine GreifswaldLaboratory of Integrative Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de LausanneSwiss Institute of BioinformaticsLocal Health Unit Toscana CentroClinical Res Branch, National Institute of AgingInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine GreifswaldDZHK (German Centre for Cardiovascular Research), partner site GreifswaldSwiss Institute of BioinformaticsEstonian Biobank, University of TartuDZHK (German Centre for Cardiovascular Research), partner site GreifswaldUniversity of Exeter Medical School, University of ExeterEndocrine, Diabetes, and Metabolism Service, Lausanne University HospitalCenter for Integrative Genomics, University of LausanneSwiss Institute of BioinformaticsIdentification of gene expression changes between healthy and diseased individuals can reveal mechanistic insights and biomarkers. Here, the authors propose a bi-directional transcriptome-wide Mendelian Randomization approach to assess causal effects between gene expression and complex traits.https://doi.org/10.1038/s41467-021-25805-y |
| spellingShingle | Eleonora Porcu Marie C. Sadler Kaido Lepik Chiara Auwerx Andrew R. Wood Antoine Weihs Maroun S. Bou Sleiman Diogo M. Ribeiro Stefania Bandinelli Toshiko Tanaka Matthias Nauck Uwe Völker Olivier Delaneau Andres Metspalu Alexander Teumer Timothy Frayling Federico A. Santoni Alexandre Reymond Zoltán Kutalik Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome Nature Communications |
| title | Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome |
| title_full | Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome |
| title_fullStr | Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome |
| title_full_unstemmed | Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome |
| title_short | Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome |
| title_sort | differentially expressed genes reflect disease induced rather than disease causing changes in the transcriptome |
| url | https://doi.org/10.1038/s41467-021-25805-y |
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