The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer
Abstract The effect of apical lymph node (APN) metastasis on the prognosis of colon cancer is unknown. The present study investigated the impact of APN metastasis on the prognosis of the patients with high-risk stage III colon cancer. This retrospective multi-institutional study included patients wi...
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Nature Portfolio
2022-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-06054-5 |
| _version_ | 1818977167757803520 |
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| author | Kenichi Ishii Jun Watanabe Kouki Goto Yusuke Suwa Kazuya Nakagawa Hirokazu Suwa Mayumi Ozawa Atsushi Ishibe Chikara Kunisaki Itaru Endo |
| author_facet | Kenichi Ishii Jun Watanabe Kouki Goto Yusuke Suwa Kazuya Nakagawa Hirokazu Suwa Mayumi Ozawa Atsushi Ishibe Chikara Kunisaki Itaru Endo |
| author_sort | Kenichi Ishii |
| collection | DOAJ |
| description | Abstract The effect of apical lymph node (APN) metastasis on the prognosis of colon cancer is unknown. The present study investigated the impact of APN metastasis on the prognosis of the patients with high-risk stage III colon cancer. This retrospective multi-institutional study included patients with pathological high-risk stage III colon cancer who underwent surgery between April 2009 and December 2014. Clinicopathological factors were examined by univariate and multivariate analyses to clarify independent risk factors for overall survival (OS) and relapse-free survival (RFS). A total of 185 patients were collected. The 5-year OS rates of patients with and without APN metastasis were 35.0% and 72.1%, respectively (p = 0.0014). The 5-year RFS rates of patients with and without APN metastasis was 16.2% and 57.2%, respectively (p = 0.0002). The rate of distant metastasis in patients with APN metastasis was significantly higher than that in patients without APN metastasis (68.8% vs. 36.7%, p = 0.012). The univariate analysis revealed that the differentiation, lymph node ratio, and APN metastasis were significantly associated with 5-year OS, and the preoperative CEA and CA19-9 levels and APN metastasis were significantly associated with 5-year RFS. The multivariate analysis showed that APN metastasis was an independent risk factor for 5-year OS and RFS. APN metastasis may be independently associated with the prognosis of patients with high-risk Stage III colon cancer. |
| first_indexed | 2024-12-20T16:23:26Z |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T16:23:26Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-b6ea33dd63b3441c9e473a4009d3abcf2022-12-21T19:33:32ZengNature PortfolioScientific Reports2045-23222022-02-011211810.1038/s41598-022-06054-5The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancerKenichi Ishii0Jun Watanabe1Kouki Goto2Yusuke Suwa3Kazuya Nakagawa4Hirokazu Suwa5Mayumi Ozawa6Atsushi Ishibe7Chikara Kunisaki8Itaru Endo9Department of Surgery, Gastroenterological Center, Yokohama City University Medical CenterDepartment of Surgery, Gastroenterological Center, Yokohama City University Medical CenterDepartment of Surgery, Gastroenterological Center, Yokohama City University Medical CenterDepartment of Surgery, Gastroenterological Center, Yokohama City University Medical CenterDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of MedicineDepartment of Surgery, Yokosuka Kyosai HospitalDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of MedicineDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of MedicineDepartment of Surgery, Gastroenterological Center, Yokohama City University Medical CenterDepartment of Gastroenterological Surgery, Yokohama City University Graduate School of MedicineAbstract The effect of apical lymph node (APN) metastasis on the prognosis of colon cancer is unknown. The present study investigated the impact of APN metastasis on the prognosis of the patients with high-risk stage III colon cancer. This retrospective multi-institutional study included patients with pathological high-risk stage III colon cancer who underwent surgery between April 2009 and December 2014. Clinicopathological factors were examined by univariate and multivariate analyses to clarify independent risk factors for overall survival (OS) and relapse-free survival (RFS). A total of 185 patients were collected. The 5-year OS rates of patients with and without APN metastasis were 35.0% and 72.1%, respectively (p = 0.0014). The 5-year RFS rates of patients with and without APN metastasis was 16.2% and 57.2%, respectively (p = 0.0002). The rate of distant metastasis in patients with APN metastasis was significantly higher than that in patients without APN metastasis (68.8% vs. 36.7%, p = 0.012). The univariate analysis revealed that the differentiation, lymph node ratio, and APN metastasis were significantly associated with 5-year OS, and the preoperative CEA and CA19-9 levels and APN metastasis were significantly associated with 5-year RFS. The multivariate analysis showed that APN metastasis was an independent risk factor for 5-year OS and RFS. APN metastasis may be independently associated with the prognosis of patients with high-risk Stage III colon cancer.https://doi.org/10.1038/s41598-022-06054-5 |
| spellingShingle | Kenichi Ishii Jun Watanabe Kouki Goto Yusuke Suwa Kazuya Nakagawa Hirokazu Suwa Mayumi Ozawa Atsushi Ishibe Chikara Kunisaki Itaru Endo The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer Scientific Reports |
| title | The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer |
| title_full | The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer |
| title_fullStr | The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer |
| title_full_unstemmed | The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer |
| title_short | The prognostic significance of apical lymph node metastasis in patients with high-risk stage III colon cancer |
| title_sort | prognostic significance of apical lymph node metastasis in patients with high risk stage iii colon cancer |
| url | https://doi.org/10.1038/s41598-022-06054-5 |
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