Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment
Synphilin-1 is a protein encoded by the human SNCAIP gene whose function has yet to be fully understood. However, it has been linked to familial Parkinson’s disease (PD). Synphilin-1 is a major component of the Lewy bodies found in neurons in the substantia nigra pars compacta of PD patients. Synphi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977059/?tool=EBI |
| _version_ | 1811160133181374464 |
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| author | Angel Carvajal-Oliveros Carmen Dominguez-Baleón Iván Sánchez-Díaz Diego Zambrano-Tipan René Hernández-Vargas Jorge M. Campusano Verónica Narváez-Padilla Enrique Reynaud |
| author_facet | Angel Carvajal-Oliveros Carmen Dominguez-Baleón Iván Sánchez-Díaz Diego Zambrano-Tipan René Hernández-Vargas Jorge M. Campusano Verónica Narváez-Padilla Enrique Reynaud |
| author_sort | Angel Carvajal-Oliveros |
| collection | DOAJ |
| description | Synphilin-1 is a protein encoded by the human SNCAIP gene whose function has yet to be fully understood. However, it has been linked to familial Parkinson’s disease (PD). Synphilin-1 is a major component of the Lewy bodies found in neurons in the substantia nigra pars compacta of PD patients. Synphilin-1 expression in serotonergic and/or dopaminergic neurons of Drosophila melanogaster induces neurodegeneration, as well as motor and non-motor PD like symptoms. In this work, we examined the contribution of the serotonergic and dopaminergic circuits in the development of PD-like phenotypes. We found that olfactory and visual symptoms are majorly contributed by the serotonergic system, and that motor symptoms and reduction in survival are mainly contributed by the dopaminergic system. Chronic nicotine treatment was able to suppress several of these symptoms. These results indicate that both the serotonergic and dopaminergic systems contribute to different aspects of PD symptomatology and that nicotine has beneficial effects on specific symptoms. |
| first_indexed | 2024-04-10T05:53:10Z |
| format | Article |
| id | doaj.art-b6ea5ff3ba57447b96bfb4d6beb57097 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T05:53:10Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b6ea5ff3ba57447b96bfb4d6beb570972023-03-04T05:31:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01183Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatmentAngel Carvajal-OliverosCarmen Dominguez-BaleónIván Sánchez-DíazDiego Zambrano-TipanRené Hernández-VargasJorge M. CampusanoVerónica Narváez-PadillaEnrique ReynaudSynphilin-1 is a protein encoded by the human SNCAIP gene whose function has yet to be fully understood. However, it has been linked to familial Parkinson’s disease (PD). Synphilin-1 is a major component of the Lewy bodies found in neurons in the substantia nigra pars compacta of PD patients. Synphilin-1 expression in serotonergic and/or dopaminergic neurons of Drosophila melanogaster induces neurodegeneration, as well as motor and non-motor PD like symptoms. In this work, we examined the contribution of the serotonergic and dopaminergic circuits in the development of PD-like phenotypes. We found that olfactory and visual symptoms are majorly contributed by the serotonergic system, and that motor symptoms and reduction in survival are mainly contributed by the dopaminergic system. Chronic nicotine treatment was able to suppress several of these symptoms. These results indicate that both the serotonergic and dopaminergic systems contribute to different aspects of PD symptomatology and that nicotine has beneficial effects on specific symptoms.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977059/?tool=EBI |
| spellingShingle | Angel Carvajal-Oliveros Carmen Dominguez-Baleón Iván Sánchez-Díaz Diego Zambrano-Tipan René Hernández-Vargas Jorge M. Campusano Verónica Narváez-Padilla Enrique Reynaud Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment PLoS ONE |
| title | Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment |
| title_full | Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment |
| title_fullStr | Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment |
| title_full_unstemmed | Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment |
| title_short | Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment |
| title_sort | parkinsonian phenotypes induced by synphilin 1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977059/?tool=EBI |
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