mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways

mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways

Summary: mTOR, the sensor of nutrients and growth factors, has important roles in tissue homeostasis and tumorigenesis. However, how mTOR controls gastric epithelial cell turnover and gastric cancer development, a leading malignancy, remains poorly understood. Here, we provide genetic evidence that...

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Bibliographic Details
Main Authors: Ke Li, Hongguang Wu, Ao Wang, Jean Charron, Yuji Mishina, Samy L. Habib, Huijuan Liu, Baojie Li
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
gastric cancer
gastric epithelial progenitor
mTOR
MEK1
Smad1
Lgr5
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004009

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