Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series
Abstract Background: Some women represent the inability to respond to endogenous and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm injection cycles leading to the follicular developmental arrest. The women with resistant ovaries could benefit from in vitro maturation....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2021-06-01
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| Series: | International Journal of Reproductive BioMedicine |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/ijrm.v19i6.9378 |
| _version_ | 1818642236939698176 |
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| author | Maryam Eftekhar Banafsheh Mohammadi Nasim Tabibnejad Mohammad Hossein Razi |
| author_facet | Maryam Eftekhar Banafsheh Mohammadi Nasim Tabibnejad Mohammad Hossein Razi |
| author_sort | Maryam Eftekhar |
| collection | DOAJ |
| description | Abstract Background: Some women represent the inability to respond to endogenous and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm injection cycles leading to the follicular developmental arrest. The women with resistant ovaries could benefit from in vitro maturation. Case: This case-series presents pregnancies resulting from initially scheduled conventional in vitro fertilization which led to arrested cycles because of resistant ovary syndrome. The protocol was changed to early oocyte triggering for 15 women due to the small follicles ≤ 12 mm in diameter on day 15 after stimulation with high doses of exogenous gonadotrophins instead of cycle cancellation. Germinal vesicle and metaphase I oocytes that were retrieved from follicles were matured in vitro and inseminated by intracytoplasmic sperm injection. Twenty formed embryos were transferred on day 3 after oocyte retrieval. This resulted in a 30.76% chemical pregnancy out of which no abortion occurred. Therefore, we reported a 30.76% singleton ongoing pregnancy. Conclusion: It seems that early oocyte triggering followed by in vitro maturation may be considered as a good modality in women experiencing follicular resistance to gonadotropins. These cycles can be rescued from cancellation with satisfactory clinical outcomes. |
| first_indexed | 2024-12-16T23:39:52Z |
| format | Article |
| id | doaj.art-b6eb1cb4061e473d8f19ee3fa9f7a49b |
| institution | Directory Open Access Journal |
| issn | 2476-4108 2476-3772 |
| language | English |
| last_indexed | 2024-12-16T23:39:52Z |
| publishDate | 2021-06-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-b6eb1cb4061e473d8f19ee3fa9f7a49b2022-12-21T22:11:38ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722021-06-0119656957410.18502/ijrm.v19i6.9378ijrm.v19i6.9378Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-seriesMaryam Eftekhar0Banafsheh Mohammadi1Nasim Tabibnejad2Mohammad Hossein Razi3Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Abstract Background: Some women represent the inability to respond to endogenous and exogenous gonadotropins during in vitro fertilization/intracytoplasmic sperm injection cycles leading to the follicular developmental arrest. The women with resistant ovaries could benefit from in vitro maturation. Case: This case-series presents pregnancies resulting from initially scheduled conventional in vitro fertilization which led to arrested cycles because of resistant ovary syndrome. The protocol was changed to early oocyte triggering for 15 women due to the small follicles ≤ 12 mm in diameter on day 15 after stimulation with high doses of exogenous gonadotrophins instead of cycle cancellation. Germinal vesicle and metaphase I oocytes that were retrieved from follicles were matured in vitro and inseminated by intracytoplasmic sperm injection. Twenty formed embryos were transferred on day 3 after oocyte retrieval. This resulted in a 30.76% chemical pregnancy out of which no abortion occurred. Therefore, we reported a 30.76% singleton ongoing pregnancy. Conclusion: It seems that early oocyte triggering followed by in vitro maturation may be considered as a good modality in women experiencing follicular resistance to gonadotropins. These cycles can be rescued from cancellation with satisfactory clinical outcomes.https://doi.org/10.18502/ijrm.v19i6.9378arrested stimulation cycle, early oocyte triggering, in vitro maturation, clinical outcome. |
| spellingShingle | Maryam Eftekhar Banafsheh Mohammadi Nasim Tabibnejad Mohammad Hossein Razi Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series International Journal of Reproductive BioMedicine arrested stimulation cycle, early oocyte triggering, in vitro maturation, clinical outcome. |
| title | Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series |
| title_full | Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series |
| title_fullStr | Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series |
| title_full_unstemmed | Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series |
| title_short | Early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome: A case-series |
| title_sort | early oocyte triggering followed by in vitro maturation is a good approach in women with resistance ovary syndrome a case series |
| topic | arrested stimulation cycle, early oocyte triggering, in vitro maturation, clinical outcome. |
| url | https://doi.org/10.18502/ijrm.v19i6.9378 |
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