Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research
Exogenous stem cell therapy (SCT) has been recognized recently as a promising neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem cells (MSCs) are the primary source of stem cells used in the majority of both pre-clinical and clinical studies in stroke. In the absenc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-12-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/0963689718806846 |
| _version_ | 1811286510777925632 |
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| author | Haiqing Zheng Bin Zhang Pratik Y. Chhatbar Yi Dong Ali Alawieh Forrest Lowe Xiquan Hu Wuwei Feng |
| author_facet | Haiqing Zheng Bin Zhang Pratik Y. Chhatbar Yi Dong Ali Alawieh Forrest Lowe Xiquan Hu Wuwei Feng |
| author_sort | Haiqing Zheng |
| collection | DOAJ |
| description | Exogenous stem cell therapy (SCT) has been recognized recently as a promising neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem cells (MSCs) are the primary source of stem cells used in the majority of both pre-clinical and clinical studies in stroke. In the absence of evidence-based guidelines on the use of SCT in stroke patients, understanding the progress of MSC research across published studies will assist researchers and clinicians in better achieving success in translating research. We conducted a systematic review on published literature using MSCs in both pre-clinical studies and clinical trials between 2008 and 2017 using the public databases PubMed and Ovid Medline, and the clinical trial registry ( www.clinicaltrials.gov ). A total of 78 pre-clinical studies and eight clinical studies were identified. While majority of the pre-clinical and clinical studies demonstrated statistically significant effects, the clinical significance of these findings was still unclear. Effect sizes could not be measured mainly due to reporting issues in pre-clinical studies, thus limiting our ability to compare results across studies quantitatively. The overall quality of both pre-clinical and clinical studies was sub-optimal. By conducting a systematic review of both pre-clinical and clinical studies on MSCs therapy in stroke, we assessed the quality of current evidence and identified several issues and gaps in translating animal studies to human trials. Addressing these issues and incorporating changes into future animal studies and human trials may lead to better success of stem cells-based therapeutics in the near future. |
| first_indexed | 2024-04-13T03:01:53Z |
| format | Article |
| id | doaj.art-b6ed5ba5f6c34e1eaaca451e070c2bee |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-04-13T03:01:53Z |
| publishDate | 2018-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-b6ed5ba5f6c34e1eaaca451e070c2bee2022-12-22T03:05:24ZengSAGE PublishingCell Transplantation0963-68971555-38922018-12-012710.1177/0963689718806846Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical ResearchHaiqing Zheng0Bin Zhang1Pratik Y. Chhatbar2Yi Dong3Ali Alawieh4Forrest Lowe5Xiquan Hu6Wuwei Feng7 Department of Neurology, Medical University of South Carolina, Charleston, SC, USA Department of Neurology, Shanghai Jiaotong University Affiliated the Sixth People’s Hospital, Shanghai, China Department of Neurology, Medical University of South Carolina, Charleston, SC, USA Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China Department of Neurology, Medical University of South Carolina, Charleston, SC, USA Department of Neurology, Medical University of South Carolina, Charleston, SC, USA Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of Neurology, Medical University of South Carolina, Charleston, SC, USAExogenous stem cell therapy (SCT) has been recognized recently as a promising neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem cells (MSCs) are the primary source of stem cells used in the majority of both pre-clinical and clinical studies in stroke. In the absence of evidence-based guidelines on the use of SCT in stroke patients, understanding the progress of MSC research across published studies will assist researchers and clinicians in better achieving success in translating research. We conducted a systematic review on published literature using MSCs in both pre-clinical studies and clinical trials between 2008 and 2017 using the public databases PubMed and Ovid Medline, and the clinical trial registry ( www.clinicaltrials.gov ). A total of 78 pre-clinical studies and eight clinical studies were identified. While majority of the pre-clinical and clinical studies demonstrated statistically significant effects, the clinical significance of these findings was still unclear. Effect sizes could not be measured mainly due to reporting issues in pre-clinical studies, thus limiting our ability to compare results across studies quantitatively. The overall quality of both pre-clinical and clinical studies was sub-optimal. By conducting a systematic review of both pre-clinical and clinical studies on MSCs therapy in stroke, we assessed the quality of current evidence and identified several issues and gaps in translating animal studies to human trials. Addressing these issues and incorporating changes into future animal studies and human trials may lead to better success of stem cells-based therapeutics in the near future.https://doi.org/10.1177/0963689718806846 |
| spellingShingle | Haiqing Zheng Bin Zhang Pratik Y. Chhatbar Yi Dong Ali Alawieh Forrest Lowe Xiquan Hu Wuwei Feng Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research Cell Transplantation |
| title | Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research |
| title_full | Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research |
| title_fullStr | Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research |
| title_full_unstemmed | Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research |
| title_short | Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research |
| title_sort | mesenchymal stem cell therapy in stroke a systematic review of literature in pre clinical and clinical research |
| url | https://doi.org/10.1177/0963689718806846 |
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