Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs.

Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs.

<h4>Background</h4>Ex-vivo lung perfusion (EVLP) is a save way to verify performance of donor lungs prior to implantation. A major problem of lung transplantation is a donor-to-recipient-transmission of bacterial cultures. Thus, a broadspectrum anti-infective treatment with sphingosine i...

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Main Authors: Henning Carstens, Katharina Kalka, Rabea Verhaegh, Fabian Schumacher, Matthias Soddemann, Barbara Wilker, Simone Keitsch, Carolin Sehl, Burkhard Kleuser, Michael Hübler, Ursula Rauen, Anne Katrin Becker, Achim Koch, Erich Gulbins, Markus Kamler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0271620

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