Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis
Objectives: The study aimed to explore the efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis. Methods: The randomized controlled study included 50 Mycobacterium tuberculosis culture or pathological-confirmed multi...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122200159X |
| _version_ | 1828349168045785088 |
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| author | Jie Qiao Lin Yang Jing Feng Xiyong Dai Feng Xu Ping Xia |
| author_facet | Jie Qiao Lin Yang Jing Feng Xiyong Dai Feng Xu Ping Xia |
| author_sort | Jie Qiao |
| collection | DOAJ |
| description | Objectives: The study aimed to explore the efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis. Methods: The randomized controlled study included 50 Mycobacterium tuberculosis culture or pathological-confirmed multidrug resistant tuberculosis patients who received spinal surgery from January 2018 to February 2020. Twenty-five patients were assigned to the control group and the study group, respectively. Random number method was used for patient allocation and they were treated with levofloxacin, pyrazinamide, thioisonicotinamide enteric-coated tablet, amikacin sulfate injection, and sodium p-amino salicylate injection, accompanied by linezolid or not. Results: The overall effective rate of the study group was higher than that of the control group (88.00% vs 64.00%, P<0.05). The severity of pain at 3 and 6 months postoperatively was lower in the study group than that in the control group (P<0.05). Postoperatively, the study group had higher bone graft fusion rate, shorter mean bone graft fusion time, and higher paraspinal cyst absorption rate than the control group (P<0.05). Postoperatively, the study group had lower levels of PCT, ESR, and CRP than the control group (P <0.05). All patients had normal hepatic and renal function, and no statistical difference of adverse effects between 2 groups were found. Conclusions: Linezolid-based chemotherapeutic regimens can effectively treat patients with postoperative multidrug-resistant spinal tuberculosis but have higher rates of adverse reactions. |
| first_indexed | 2024-04-14T01:05:41Z |
| format | Article |
| id | doaj.art-b6ef17cbe5b44e09b3e3d2719f3e0952 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-14T01:05:41Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-b6ef17cbe5b44e09b3e3d2719f3e09522022-12-22T02:21:15ZengElsevierInternational Journal of Infectious Diseases1201-97122022-05-01118264269Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosisJie Qiao0Lin Yang1Jing Feng2Xiyong Dai3Feng Xu4Ping Xia5Department of Orthopedics, The Central Hospital of Wuhan, Wuhan, ChinaDepartment of Orthopedics, The Central Hospital of Wuhan, Wuhan, China; Hubei University of Chinese Medicine,Wuhan, China; Department of Surgery, Wuhan Pulmonary Hospital, Wuhan, China; Department of Orthopedics, Wuhan No.1 Hospital, Wuhan, ChinaDepartment of Orthopedics, The Central Hospital of Wuhan, Wuhan, China; Hubei University of Chinese Medicine,Wuhan, China; Department of Surgery, Wuhan Pulmonary Hospital, Wuhan, China; Department of Orthopedics, Wuhan No.1 Hospital, Wuhan, ChinaDepartment of Orthopedics, The Central Hospital of Wuhan, Wuhan, China; Hubei University of Chinese Medicine,Wuhan, China; Department of Surgery, Wuhan Pulmonary Hospital, Wuhan, China; Department of Orthopedics, Wuhan No.1 Hospital, Wuhan, ChinaDepartment of Orthopedics, The Central Hospital of Wuhan, Wuhan, China; Hubei University of Chinese Medicine,Wuhan, China; Department of Surgery, Wuhan Pulmonary Hospital, Wuhan, China; Department of Orthopedics, Wuhan No.1 Hospital, Wuhan, ChinaDepartment of Orthopedics, The Central Hospital of Wuhan, Wuhan, China; Corresponding author: Ping Xia, Department of Orthopedics, The Central Hospital of Wuhan, No.26 Shengli Street, Jiangan District, Wuhan, Hubei 430014, China; Tel.: +86- 15607181066.Objectives: The study aimed to explore the efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis. Methods: The randomized controlled study included 50 Mycobacterium tuberculosis culture or pathological-confirmed multidrug resistant tuberculosis patients who received spinal surgery from January 2018 to February 2020. Twenty-five patients were assigned to the control group and the study group, respectively. Random number method was used for patient allocation and they were treated with levofloxacin, pyrazinamide, thioisonicotinamide enteric-coated tablet, amikacin sulfate injection, and sodium p-amino salicylate injection, accompanied by linezolid or not. Results: The overall effective rate of the study group was higher than that of the control group (88.00% vs 64.00%, P<0.05). The severity of pain at 3 and 6 months postoperatively was lower in the study group than that in the control group (P<0.05). Postoperatively, the study group had higher bone graft fusion rate, shorter mean bone graft fusion time, and higher paraspinal cyst absorption rate than the control group (P<0.05). Postoperatively, the study group had lower levels of PCT, ESR, and CRP than the control group (P <0.05). All patients had normal hepatic and renal function, and no statistical difference of adverse effects between 2 groups were found. Conclusions: Linezolid-based chemotherapeutic regimens can effectively treat patients with postoperative multidrug-resistant spinal tuberculosis but have higher rates of adverse reactions.http://www.sciencedirect.com/science/article/pii/S120197122200159XLinezolid-based chemotherapeutic regimenspostoperative multidrug-resistant spinal tuberculosisefficacysafety |
| spellingShingle | Jie Qiao Lin Yang Jing Feng Xiyong Dai Feng Xu Ping Xia Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis International Journal of Infectious Diseases Linezolid-based chemotherapeutic regimens postoperative multidrug-resistant spinal tuberculosis efficacy safety |
| title | Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis |
| title_full | Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis |
| title_fullStr | Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis |
| title_full_unstemmed | Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis |
| title_short | Analysis of efficacy and safety of linezolid-based chemotherapeutic regimens for patients with postoperative multidrug-resistant spinal tuberculosis |
| title_sort | analysis of efficacy and safety of linezolid based chemotherapeutic regimens for patients with postoperative multidrug resistant spinal tuberculosis |
| topic | Linezolid-based chemotherapeutic regimens postoperative multidrug-resistant spinal tuberculosis efficacy safety |
| url | http://www.sciencedirect.com/science/article/pii/S120197122200159X |
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