Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment
Cancer is a complex and multifaceted disease that continues to be a global health challenge. It exerts a tremendous burden on individuals, families, healthcare systems, and society as a whole. To mitigate the impact of cancer, concerted efforts and collaboration on a global scale are essential. This...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/9/2337 |
| _version_ | 1827724429808893952 |
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| author | Rile Ou Gerile Aodeng Jun Ai |
| author_facet | Rile Ou Gerile Aodeng Jun Ai |
| author_sort | Rile Ou |
| collection | DOAJ |
| description | Cancer is a complex and multifaceted disease that continues to be a global health challenge. It exerts a tremendous burden on individuals, families, healthcare systems, and society as a whole. To mitigate the impact of cancer, concerted efforts and collaboration on a global scale are essential. This includes strengthening preventive measures, promoting early detection, and advancing effective treatment strategies. In the field of cancer treatment, researchers and clinicians are constantly seeking new approaches and technologies to improve therapeutic outcomes and minimize adverse effects. One promising avenue of investigation is the utilization of the Fenton reaction, a chemical process that involves the generation of highly reactive hydroxyl radicals (·OH) through the interaction of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) with ferrous ions (Fe<sup>2+</sup>). The generated ·OH radicals possess strong oxidative properties, which can lead to the selective destruction of cancer cells. In recent years, researchers have successfully introduced the Fenton reaction into the cancer microenvironment through the application of nanotechnology, such as polymer nanoparticles and light-responsive nanoparticles. This article reviews the progress of the application of the Fenton reaction, catalyzed by polymer nanoparticles and light-responsive nanoparticles, in the cancer microenvironment, as well as the potential applications and future development directions of the Fenton reaction in the field of tumor treatment. |
| first_indexed | 2024-03-10T22:15:40Z |
| format | Article |
| id | doaj.art-b6ef1c5e24534c958e73801b20eb4fdf |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T22:15:40Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b6ef1c5e24534c958e73801b20eb4fdf2023-11-19T12:28:23ZengMDPI AGPharmaceutics1999-49232023-09-01159233710.3390/pharmaceutics15092337Advancements in the Application of the Fenton Reaction in the Cancer MicroenvironmentRile Ou0Gerile Aodeng1Jun Ai2Inner Mongolia Key Laboratory of Environmental Chemistry, College of Chemistry and Enviromental Science, Inner Mongolia Normal University, 81 Zhaowudalu, Hohhot 010022, ChinaInner Mongolia Key Laboratory of Environmental Chemistry, College of Chemistry and Enviromental Science, Inner Mongolia Normal University, 81 Zhaowudalu, Hohhot 010022, ChinaInner Mongolia Key Laboratory of Environmental Chemistry, College of Chemistry and Enviromental Science, Inner Mongolia Normal University, 81 Zhaowudalu, Hohhot 010022, ChinaCancer is a complex and multifaceted disease that continues to be a global health challenge. It exerts a tremendous burden on individuals, families, healthcare systems, and society as a whole. To mitigate the impact of cancer, concerted efforts and collaboration on a global scale are essential. This includes strengthening preventive measures, promoting early detection, and advancing effective treatment strategies. In the field of cancer treatment, researchers and clinicians are constantly seeking new approaches and technologies to improve therapeutic outcomes and minimize adverse effects. One promising avenue of investigation is the utilization of the Fenton reaction, a chemical process that involves the generation of highly reactive hydroxyl radicals (·OH) through the interaction of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) with ferrous ions (Fe<sup>2+</sup>). The generated ·OH radicals possess strong oxidative properties, which can lead to the selective destruction of cancer cells. In recent years, researchers have successfully introduced the Fenton reaction into the cancer microenvironment through the application of nanotechnology, such as polymer nanoparticles and light-responsive nanoparticles. This article reviews the progress of the application of the Fenton reaction, catalyzed by polymer nanoparticles and light-responsive nanoparticles, in the cancer microenvironment, as well as the potential applications and future development directions of the Fenton reaction in the field of tumor treatment.https://www.mdpi.com/1999-4923/15/9/2337Fenton-reactionmalignant tumornanoparticles |
| spellingShingle | Rile Ou Gerile Aodeng Jun Ai Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment Pharmaceutics Fenton-reaction malignant tumor nanoparticles |
| title | Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment |
| title_full | Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment |
| title_fullStr | Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment |
| title_full_unstemmed | Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment |
| title_short | Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment |
| title_sort | advancements in the application of the fenton reaction in the cancer microenvironment |
| topic | Fenton-reaction malignant tumor nanoparticles |
| url | https://www.mdpi.com/1999-4923/15/9/2337 |
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