Evaluation of Chronic Hepatitis C in Patients with Diabetes Mellitus
Introduction: Chronic hepatitis C induces hepatosteatosis, causes insulin resistance increasing tumor necrosis factor-alfa (TNF- α), and leads to the development of type 2 diabetes. This study aimed to evaluate the prevalence of hepatitis C virus (HCV) and its risk factors in the diabetic patients....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Turkish |
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Galenos Yayinevi
2014-12-01
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| Series: | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| Subjects: |
| _version_ | 1797923423800786944 |
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| author | Şükran KÖSE Gürsel ERSAN Pelin ADAR Ufuk SÖNMEZ Sabri ATALAY |
| author_facet | Şükran KÖSE Gürsel ERSAN Pelin ADAR Ufuk SÖNMEZ Sabri ATALAY |
| author_sort | Şükran KÖSE |
| collection | DOAJ |
| description | Introduction: Chronic hepatitis C induces hepatosteatosis, causes insulin resistance increasing tumor necrosis factor-alfa (TNF- α), and leads to the development of type 2 diabetes. This study aimed to evaluate the prevalence of hepatitis C virus (HCV) and its risk factors in the diabetic patients.
Materials and Methods: Four hundred and twenty patients over 18 years of age diagnosed with diabetes in internal medicine services of our hospital were evaluated, retrospectively. Anti-HCV was evaluated by ELISA (Liaison, Diasorin, Italy) and HCVRNA was evaluated by real-time polymerase chain reaction (Ampliprep/Cobas Taqman HCV Quantitive Test, v2.0 Roche, Germany) in patients seropositive for Anti-HCV.
Results: The mean age of 420 patients was 64.7 (29-86) years and 54% (229 patient) were male. Among the patients, 92.8% (390) had type 2 diabetes and 7.2% (30) had type 1 diabetes, the mean time period for diabetes was 10.1 years (ranged between 1-43). Only one patient (0.2%) in the study having a history of surgery and transfusion was found to be seropositive for anti-HCV and confirmed by HCV-RNA test.
Conclusion: In this study, HCV was investigated in diabetic cases but no association was found between the increasing prevalance of HCV and diabetes mellitus. However, it is considered that the prevalence of HCV may increase due to the complications of HCV and some genotypes of HCV that leads to diabetes, and invasive operations such as transfusion, catheterization and hemodialysis. |
| first_indexed | 2024-04-10T14:46:09Z |
| format | Article |
| id | doaj.art-b6f04d465eef4c3299a3de4f5c3684f1 |
| institution | Directory Open Access Journal |
| issn | 2147-673X |
| language | Turkish |
| last_indexed | 2024-04-10T14:46:09Z |
| publishDate | 2014-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Mediterranean Journal of Infection, Microbes and Antimicrobials |
| spelling | doaj.art-b6f04d465eef4c3299a3de4f5c3684f12023-02-15T16:07:53ZturGalenos YayineviMediterranean Journal of Infection, Microbes and Antimicrobials2147-673X2014-12-01310.5578/mjima.7897Evaluation of Chronic Hepatitis C in Patients with Diabetes MellitusŞükran KÖSE0Gürsel ERSAN1Pelin ADAR2Ufuk SÖNMEZ3Sabri ATALAY4İzmir Tepecik Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İzmir, Türkiyeİzmir Tepecik Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İzmir, Türkiyeİzmir Tepecik Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İzmir, Türkiyeİzmir Tepecik Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İzmir, Türkiyeİzmir Tepecik Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İzmir, TürkiyeIntroduction: Chronic hepatitis C induces hepatosteatosis, causes insulin resistance increasing tumor necrosis factor-alfa (TNF- α), and leads to the development of type 2 diabetes. This study aimed to evaluate the prevalence of hepatitis C virus (HCV) and its risk factors in the diabetic patients. Materials and Methods: Four hundred and twenty patients over 18 years of age diagnosed with diabetes in internal medicine services of our hospital were evaluated, retrospectively. Anti-HCV was evaluated by ELISA (Liaison, Diasorin, Italy) and HCVRNA was evaluated by real-time polymerase chain reaction (Ampliprep/Cobas Taqman HCV Quantitive Test, v2.0 Roche, Germany) in patients seropositive for Anti-HCV. Results: The mean age of 420 patients was 64.7 (29-86) years and 54% (229 patient) were male. Among the patients, 92.8% (390) had type 2 diabetes and 7.2% (30) had type 1 diabetes, the mean time period for diabetes was 10.1 years (ranged between 1-43). Only one patient (0.2%) in the study having a history of surgery and transfusion was found to be seropositive for anti-HCV and confirmed by HCV-RNA test. Conclusion: In this study, HCV was investigated in diabetic cases but no association was found between the increasing prevalance of HCV and diabetes mellitus. However, it is considered that the prevalence of HCV may increase due to the complications of HCV and some genotypes of HCV that leads to diabetes, and invasive operations such as transfusion, catheterization and hemodialysis.Diabetes mellituschronic hepatitis Ccomplication |
| spellingShingle | Şükran KÖSE Gürsel ERSAN Pelin ADAR Ufuk SÖNMEZ Sabri ATALAY Evaluation of Chronic Hepatitis C in Patients with Diabetes Mellitus Mediterranean Journal of Infection, Microbes and Antimicrobials Diabetes mellitus chronic hepatitis C complication |
| title | Evaluation of Chronic Hepatitis C in Patients with Diabetes Mellitus |
| title_full | Evaluation of Chronic Hepatitis C in Patients with Diabetes Mellitus |
| title_fullStr | Evaluation of Chronic Hepatitis C in Patients with Diabetes Mellitus |
| title_full_unstemmed | Evaluation of Chronic Hepatitis C in Patients with Diabetes Mellitus |
| title_short | Evaluation of Chronic Hepatitis C in Patients with Diabetes Mellitus |
| title_sort | evaluation of chronic hepatitis c in patients with diabetes mellitus |
| topic | Diabetes mellitus chronic hepatitis C complication |
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