Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury
IntroductionPhytochemicals present in Moringa oleifera (M. oleifera) leaves have performed several physiological functions in human system such as anticarcinogenic, antidiabetic, antioxidant, immunomodulatory, hepatoprotective and antiatherogenic functions.MethodsPhytochemical and antioxidant potent...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1078896/full |
| _version_ | 1828270395838431232 |
|---|---|
| author | Noor Younis Muhammad Issa Khan Tahir Zahoor Muhammad Naeem Faisal |
| author_facet | Noor Younis Muhammad Issa Khan Tahir Zahoor Muhammad Naeem Faisal |
| author_sort | Noor Younis |
| collection | DOAJ |
| description | IntroductionPhytochemicals present in Moringa oleifera (M. oleifera) leaves have performed several physiological functions in human system such as anticarcinogenic, antidiabetic, antioxidant, immunomodulatory, hepatoprotective and antiatherogenic functions.MethodsPhytochemical and antioxidant potential of M. oleifera leaves extracts were measured. Histopathology, biochemical analysis, and gene expression tests were performed on serum, blood, and liver in animal model.Results and discussionsThe toxic dose of N-acetyl-para-aminophenol (APAP) induced severe structural and functional changes in liver. Pre-treatment with M. oleifera ameliorated organ injury by normalizing the level of liver biomarkers and serum proteins. A low expression level of MAPK-8, TRAF-4, and TRAF-6 genes was observed in the M. oleifera treated group in comparison to positive control (hepatotoxic rats). M. oleifera leaves pretreatment amended APAP induced apoptosis and replenished hepatic cells. M. oleifera leaves extract as low-cost and sustainable treatment could be used in pharmaceutical industry for reducing hepatic degenerative changes in non-communicable diseases. |
| first_indexed | 2024-04-13T05:42:30Z |
| format | Article |
| id | doaj.art-b6f0a9994c67475b98d6052b0a34a1b2 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T05:42:30Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-b6f0a9994c67475b98d6052b0a34a1b22022-12-22T03:00:03ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-12-01910.3389/fnut.2022.10788961078896Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injuryNoor Younis0Muhammad Issa Khan1Tahir Zahoor2Muhammad Naeem Faisal3National Institute of Food Science and Technology, University of Agriculture, Faisalabad, PakistanNational Institute of Food Science and Technology, University of Agriculture, Faisalabad, PakistanNational Institute of Food Science and Technology, University of Agriculture, Faisalabad, PakistanInstitute of Physiology and Pharmacology, University of Agriculture, Faisalabad, PakistanIntroductionPhytochemicals present in Moringa oleifera (M. oleifera) leaves have performed several physiological functions in human system such as anticarcinogenic, antidiabetic, antioxidant, immunomodulatory, hepatoprotective and antiatherogenic functions.MethodsPhytochemical and antioxidant potential of M. oleifera leaves extracts were measured. Histopathology, biochemical analysis, and gene expression tests were performed on serum, blood, and liver in animal model.Results and discussionsThe toxic dose of N-acetyl-para-aminophenol (APAP) induced severe structural and functional changes in liver. Pre-treatment with M. oleifera ameliorated organ injury by normalizing the level of liver biomarkers and serum proteins. A low expression level of MAPK-8, TRAF-4, and TRAF-6 genes was observed in the M. oleifera treated group in comparison to positive control (hepatotoxic rats). M. oleifera leaves pretreatment amended APAP induced apoptosis and replenished hepatic cells. M. oleifera leaves extract as low-cost and sustainable treatment could be used in pharmaceutical industry for reducing hepatic degenerative changes in non-communicable diseases.https://www.frontiersin.org/articles/10.3389/fnut.2022.1078896/fullMoringa oleiferaacetaminophenhepatic injuryantioxidant potentialsilymarin |
| spellingShingle | Noor Younis Muhammad Issa Khan Tahir Zahoor Muhammad Naeem Faisal Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury Frontiers in Nutrition Moringa oleifera acetaminophen hepatic injury antioxidant potential silymarin |
| title | Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury |
| title_full | Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury |
| title_fullStr | Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury |
| title_full_unstemmed | Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury |
| title_short | Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury |
| title_sort | phytochemical and antioxidant screening of moringa oleifera for its utilization in the management of hepatic injury |
| topic | Moringa oleifera acetaminophen hepatic injury antioxidant potential silymarin |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1078896/full |
| work_keys_str_mv | AT nooryounis phytochemicalandantioxidantscreeningofmoringaoleiferaforitsutilizationinthemanagementofhepaticinjury AT muhammadissakhan phytochemicalandantioxidantscreeningofmoringaoleiferaforitsutilizationinthemanagementofhepaticinjury AT tahirzahoor phytochemicalandantioxidantscreeningofmoringaoleiferaforitsutilizationinthemanagementofhepaticinjury AT muhammadnaeemfaisal phytochemicalandantioxidantscreeningofmoringaoleiferaforitsutilizationinthemanagementofhepaticinjury |