Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy
Introduction: Proteinuria is a common complication in patients with type 2 diabetic nephropathy (DN). The aim of this study was to evaluate the anti-proteinuria effect of active vitamin D in patients with type 2 DN. Methods: A double-blind randomized clinical trial study was conducted on 42 DN patie...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=12;spage=7735;epage=7742;aulast=Aref |
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| author | Asieh Aref Mina Khodhal Homeira Rashidi Zahra Farhangiyan Saeid Bitaraf |
| author_facet | Asieh Aref Mina Khodhal Homeira Rashidi Zahra Farhangiyan Saeid Bitaraf |
| author_sort | Asieh Aref |
| collection | DOAJ |
| description | Introduction: Proteinuria is a common complication in patients with type 2 diabetic nephropathy (DN). The aim of this study was to evaluate the anti-proteinuria effect of active vitamin D in patients with type 2 DN. Methods: A double-blind randomized clinical trial study was conducted on 42 DN patients selected by convenience sampling method. After selecting patients based on inclusion criteria, they were randomly divided into control and intervention groups. Patients in the intervention group received 0.25 mg of active vitamin D per day for 12 weeks. The variables evaluated in the patients on the first day of the intervention included fasting blood sugar (FBS), calcium, phosphorus, creatinine, glomerular filtration rate (GFR), systolic and diastolic blood pressure, and proteinuria. These variables were also evaluated at the end of the first, second, and third month of intervention. Data were collected and analyzed in Statistical Package for Social Sciences software version 22. Results: Around 52.5% of the patients participating in this study were male and 47.5% were female. The mean age of the patients was 55.52 ± 6.58 years. The results of repeated measures analysis showed that active vitamin D significantly reduced proteinuria (P = 0.000) in patients in the intervention group. The changes in FBS (P = 0.235), calcium (P = 0.393), phosphorus (P = 0.694), creatinine (P = 0.232), GFR (P = 0.347), systolic blood pressure (P = 0.615), and diastolic blood pressure (P = 0.115) were not significant in patients in the intervention group. Conclusion: Prescription of active vitamin D can significantly reduce the incidence of proteinuria in patients with DN. |
| first_indexed | 2024-04-10T09:55:46Z |
| format | Article |
| id | doaj.art-b6f18fe417ff4d09b06c6daeb3c6948d |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-04-10T09:55:46Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-b6f18fe417ff4d09b06c6daeb3c6948d2023-02-16T12:30:40ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632022-01-0111127735774210.4103/jfmpc.jfmpc_627_22Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathyAsieh ArefMina KhodhalHomeira RashidiZahra FarhangiyanSaeid BitarafIntroduction: Proteinuria is a common complication in patients with type 2 diabetic nephropathy (DN). The aim of this study was to evaluate the anti-proteinuria effect of active vitamin D in patients with type 2 DN. Methods: A double-blind randomized clinical trial study was conducted on 42 DN patients selected by convenience sampling method. After selecting patients based on inclusion criteria, they were randomly divided into control and intervention groups. Patients in the intervention group received 0.25 mg of active vitamin D per day for 12 weeks. The variables evaluated in the patients on the first day of the intervention included fasting blood sugar (FBS), calcium, phosphorus, creatinine, glomerular filtration rate (GFR), systolic and diastolic blood pressure, and proteinuria. These variables were also evaluated at the end of the first, second, and third month of intervention. Data were collected and analyzed in Statistical Package for Social Sciences software version 22. Results: Around 52.5% of the patients participating in this study were male and 47.5% were female. The mean age of the patients was 55.52 ± 6.58 years. The results of repeated measures analysis showed that active vitamin D significantly reduced proteinuria (P = 0.000) in patients in the intervention group. The changes in FBS (P = 0.235), calcium (P = 0.393), phosphorus (P = 0.694), creatinine (P = 0.232), GFR (P = 0.347), systolic blood pressure (P = 0.615), and diastolic blood pressure (P = 0.115) were not significant in patients in the intervention group. Conclusion: Prescription of active vitamin D can significantly reduce the incidence of proteinuria in patients with DN.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=12;spage=7735;epage=7742;aulast=Arefactive vitamin danti-proteinuriadiabetic nephropathytype 2 diabetes mellitus |
| spellingShingle | Asieh Aref Mina Khodhal Homeira Rashidi Zahra Farhangiyan Saeid Bitaraf Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy Journal of Family Medicine and Primary Care active vitamin d anti-proteinuria diabetic nephropathy type 2 diabetes mellitus |
| title | Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy |
| title_full | Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy |
| title_fullStr | Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy |
| title_full_unstemmed | Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy |
| title_short | Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy |
| title_sort | anti proteinuria effect of active vitamin d in patients with type 2 diabetic nephropathy |
| topic | active vitamin d anti-proteinuria diabetic nephropathy type 2 diabetes mellitus |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2022;volume=11;issue=12;spage=7735;epage=7742;aulast=Aref |
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