THE ROLE OF LABORATORY METHODS IN DIAGNOSIS AND FOLLOW-UP OF PATIENTS WITH TUBERCULOSIS
Objective. To conduct a literature review regarding the role of laboratory methods in diagnosis and follow-up of patients with tuberculosis for establishing the need for developing new diagnostic techniques and methods. Material and methods. A systematic literature review was conducted through wh...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Association of Surgeons of the Republic of Moldova
2022-11-01
|
| Series: | Arta Medica |
| Subjects: | |
| Online Access: | https://artamedica.md/index.php/artamedica/article/view/209 |
| _version_ | 1811232685007306752 |
|---|---|
| author | Evelina Lesnic Serghei Ghinda |
| author_facet | Evelina Lesnic Serghei Ghinda |
| author_sort | Evelina Lesnic |
| collection | DOAJ |
| description |
Objective. To conduct a literature review regarding the role of laboratory methods in diagnosis and follow-up of patients with tuberculosis for establishing the need for developing new diagnostic techniques and methods.
Material and methods. A systematic literature review was conducted through which the electronic sources published in PubMed and HINARI collection of health literature, and printed material searched according to the Universal Decimal Classification (UDC) were evaluated. The results were grouped and systematized according to the level of scientific evidence.
Results. Microbiological methods are recommended in all patients with tuberculosis, for diagnosis and follow-up. The most used immune test is the tuberculin skin test. The disorders of the immune are currently evaluated according to the white cell blood count. Immune research could not provide relevant and reproducible biomarkers.
Conclusions. Dynamic approach for the research on immune biomarkers in longitudinal studies, on a large number of patients and multianalyte assays, could provide predictive immune biomarkers to be used for the correction of the anti-TB treatment and intensification of immune modulating treatment.
|
| first_indexed | 2024-04-12T11:07:07Z |
| format | Article |
| id | doaj.art-b6f232d5311443209e2632a13c6e8088 |
| institution | Directory Open Access Journal |
| issn | 1810-1852 1810-1879 |
| language | English |
| last_indexed | 2024-04-12T11:07:07Z |
| publishDate | 2022-11-01 |
| publisher | Association of Surgeons of the Republic of Moldova |
| record_format | Article |
| series | Arta Medica |
| spelling | doaj.art-b6f232d5311443209e2632a13c6e80882022-12-22T03:35:44ZengAssociation of Surgeons of the Republic of MoldovaArta Medica1810-18521810-18792022-11-0184310.5281/zenodo.7305543THE ROLE OF LABORATORY METHODS IN DIAGNOSIS AND FOLLOW-UP OF PATIENTS WITH TUBERCULOSISEvelina Lesnic0Serghei Ghinda1State University of Medicine and Pharmacy ”Nicolae Testemițanu”, Chișinău, Republic of MoldovaInstitute of Phthisiopneumology „Chiril Draganiuc”, Chișinău, Republic of Moldova Objective. To conduct a literature review regarding the role of laboratory methods in diagnosis and follow-up of patients with tuberculosis for establishing the need for developing new diagnostic techniques and methods. Material and methods. A systematic literature review was conducted through which the electronic sources published in PubMed and HINARI collection of health literature, and printed material searched according to the Universal Decimal Classification (UDC) were evaluated. The results were grouped and systematized according to the level of scientific evidence. Results. Microbiological methods are recommended in all patients with tuberculosis, for diagnosis and follow-up. The most used immune test is the tuberculin skin test. The disorders of the immune are currently evaluated according to the white cell blood count. Immune research could not provide relevant and reproducible biomarkers. Conclusions. Dynamic approach for the research on immune biomarkers in longitudinal studies, on a large number of patients and multianalyte assays, could provide predictive immune biomarkers to be used for the correction of the anti-TB treatment and intensification of immune modulating treatment. https://artamedica.md/index.php/artamedica/article/view/209microbiology, immunology, tuberculosis, diagnosis, follow-up |
| spellingShingle | Evelina Lesnic Serghei Ghinda THE ROLE OF LABORATORY METHODS IN DIAGNOSIS AND FOLLOW-UP OF PATIENTS WITH TUBERCULOSIS Arta Medica microbiology, immunology, tuberculosis, diagnosis, follow-up |
| title | THE ROLE OF LABORATORY METHODS IN DIAGNOSIS AND FOLLOW-UP OF PATIENTS WITH TUBERCULOSIS |
| title_full | THE ROLE OF LABORATORY METHODS IN DIAGNOSIS AND FOLLOW-UP OF PATIENTS WITH TUBERCULOSIS |
| title_fullStr | THE ROLE OF LABORATORY METHODS IN DIAGNOSIS AND FOLLOW-UP OF PATIENTS WITH TUBERCULOSIS |
| title_full_unstemmed | THE ROLE OF LABORATORY METHODS IN DIAGNOSIS AND FOLLOW-UP OF PATIENTS WITH TUBERCULOSIS |
| title_short | THE ROLE OF LABORATORY METHODS IN DIAGNOSIS AND FOLLOW-UP OF PATIENTS WITH TUBERCULOSIS |
| title_sort | role of laboratory methods in diagnosis and follow up of patients with tuberculosis |
| topic | microbiology, immunology, tuberculosis, diagnosis, follow-up |
| url | https://artamedica.md/index.php/artamedica/article/view/209 |
| work_keys_str_mv | AT evelinalesnic theroleoflaboratorymethodsindiagnosisandfollowupofpatientswithtuberculosis AT sergheighinda theroleoflaboratorymethodsindiagnosisandfollowupofpatientswithtuberculosis AT evelinalesnic roleoflaboratorymethodsindiagnosisandfollowupofpatientswithtuberculosis AT sergheighinda roleoflaboratorymethodsindiagnosisandfollowupofpatientswithtuberculosis |