Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles
Abstract Selenium (Se), a well‐known essential element in human health, plays a vital role in regulating metabolism owing to its antioxidative nature. However, organic Se compounds are toxic and cannot be used for biomedical applications. Selenium nanoparticles (SeNPs) exhibit low biological toxicit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Biosurface and Biotribology |
| Subjects: | |
| Online Access: | https://doi.org/10.1049/bsb2.12067 |
| _version_ | 1797374244805410816 |
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| author | Rong Hu Xiao Wang Lu Han Xiong Lu |
| author_facet | Rong Hu Xiao Wang Lu Han Xiong Lu |
| author_sort | Rong Hu |
| collection | DOAJ |
| description | Abstract Selenium (Se), a well‐known essential element in human health, plays a vital role in regulating metabolism owing to its antioxidative nature. However, organic Se compounds are toxic and cannot be used for biomedical applications. Selenium nanoparticles (SeNPs) exhibit low biological toxicity and high bioavailability; however, they are prone to aggregation and are extremely unstable, thereby diminishing their bioactivity and bioavailability. To overcome these limitations, ultra‐small, highly stable, and bioactive SeNPs were synthesised based on an in‐situ hybridisation strategy by using polyphenol‐grafted‐chitosan (GA‐CS) to control and restrict crystal growth of Se nanoparticles. The resultant GA‐CS@nSe exhibited an average particle size of ∼30 nm and was highly stable in aqueous solutions. In addition, GA‐CS@nSe displayed improved biocompatibility and enhanced antioxidative activity. Taken together, the authors provide a basis for polyphenol‐mediated construction of Se‐based particles with increased bioactivity. |
| first_indexed | 2024-03-08T19:02:05Z |
| format | Article |
| id | doaj.art-b6f2ca5d283249a493fa3473720ec96c |
| institution | Directory Open Access Journal |
| issn | 2405-4518 |
| language | English |
| last_indexed | 2024-03-08T19:02:05Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biosurface and Biotribology |
| spelling | doaj.art-b6f2ca5d283249a493fa3473720ec96c2023-12-28T04:57:57ZengWileyBiosurface and Biotribology2405-45182023-11-019415116010.1049/bsb2.12067Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticlesRong Hu0Xiao Wang1Lu Han2Xiong Lu3School of Materials Science and Engineering Key Lab of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University Chengdu Sichuan ChinaSchool of Materials Science and Engineering Key Lab of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University Chengdu Sichuan ChinaKey Laboratory of Marine Drugs Ministry of Education School of Medicine and Pharmaceutics Ocean University of China Qingdao Shandong ChinaSchool of Materials Science and Engineering Key Lab of Advanced Technologies of Materials Ministry of Education Southwest Jiaotong University Chengdu Sichuan ChinaAbstract Selenium (Se), a well‐known essential element in human health, plays a vital role in regulating metabolism owing to its antioxidative nature. However, organic Se compounds are toxic and cannot be used for biomedical applications. Selenium nanoparticles (SeNPs) exhibit low biological toxicity and high bioavailability; however, they are prone to aggregation and are extremely unstable, thereby diminishing their bioactivity and bioavailability. To overcome these limitations, ultra‐small, highly stable, and bioactive SeNPs were synthesised based on an in‐situ hybridisation strategy by using polyphenol‐grafted‐chitosan (GA‐CS) to control and restrict crystal growth of Se nanoparticles. The resultant GA‐CS@nSe exhibited an average particle size of ∼30 nm and was highly stable in aqueous solutions. In addition, GA‐CS@nSe displayed improved biocompatibility and enhanced antioxidative activity. Taken together, the authors provide a basis for polyphenol‐mediated construction of Se‐based particles with increased bioactivity.https://doi.org/10.1049/bsb2.12067bioactivitybiomaterials |
| spellingShingle | Rong Hu Xiao Wang Lu Han Xiong Lu Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles Biosurface and Biotribology bioactivity biomaterials |
| title | Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles |
| title_full | Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles |
| title_fullStr | Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles |
| title_full_unstemmed | Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles |
| title_short | Polyphenol‐mediated construction of highly stable and bioactive selenium nanoparticles |
| title_sort | polyphenol mediated construction of highly stable and bioactive selenium nanoparticles |
| topic | bioactivity biomaterials |
| url | https://doi.org/10.1049/bsb2.12067 |
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