Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells.
While numerous studies have described the pathogenic and carcinogenic effects of nickel compounds, little has been done on the biological effects of metallic nickel. Moreover, the carcinogenetic potential of metallic nickel nanoparticles is unknown. Activator protein-1 (AP-1) and nuclear factor-κB (...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3972196?pdf=render |
| _version_ | 1818942037112651776 |
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| author | Ruth Magaye Qi Zhou Linda Bowman Baobo Zou Guochuan Mao Jin Xu Vincent Castranova Jinshun Zhao Min Ding |
| author_facet | Ruth Magaye Qi Zhou Linda Bowman Baobo Zou Guochuan Mao Jin Xu Vincent Castranova Jinshun Zhao Min Ding |
| author_sort | Ruth Magaye |
| collection | DOAJ |
| description | While numerous studies have described the pathogenic and carcinogenic effects of nickel compounds, little has been done on the biological effects of metallic nickel. Moreover, the carcinogenetic potential of metallic nickel nanoparticles is unknown. Activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) have been shown to play pivotal roles in tumor initiation, promotion, and progression. Mutation of the p53 tumor suppressor gene is considered to be one of the steps leading to the neoplastic state. The present study examines effects of metallic nickel fine and nanoparticles on tumor promoter or suppressor gene expressions as well as on cell transformation in JB6 cells. Our results demonstrate that metallic nickel nanoparticles caused higher activation of AP-1 and NF-κB, and a greater decrease of p53 transcription activity than fine particles. Western blot indicates that metallic nickel nanoparticles induced a higher level of protein expressions for R-Ras, c-myc, C-Jun, p65, and p50 in a time-dependent manner. In addition, both metallic nickel nano- and fine particles increased anchorage-independent colony formation in JB6 P+ cells in the soft agar assay. These results imply that metallic nickel fine and nanoparticles are both carcinogenetic in vitro in JB6 cells. Moreover, metallic nickel nanoparticles may exhibit higher carcinogenic potential, which suggests that precautionary measures should be taken in the use of nickel nanoparticles or its compounds in nanomedicine. |
| first_indexed | 2024-12-20T07:05:03Z |
| format | Article |
| id | doaj.art-b6f3d45c751843b580277b239af9f1a5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T07:05:03Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b6f3d45c751843b580277b239af9f1a52022-12-21T19:49:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9241810.1371/journal.pone.0092418Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells.Ruth MagayeQi ZhouLinda BowmanBaobo ZouGuochuan MaoJin XuVincent CastranovaJinshun ZhaoMin DingWhile numerous studies have described the pathogenic and carcinogenic effects of nickel compounds, little has been done on the biological effects of metallic nickel. Moreover, the carcinogenetic potential of metallic nickel nanoparticles is unknown. Activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) have been shown to play pivotal roles in tumor initiation, promotion, and progression. Mutation of the p53 tumor suppressor gene is considered to be one of the steps leading to the neoplastic state. The present study examines effects of metallic nickel fine and nanoparticles on tumor promoter or suppressor gene expressions as well as on cell transformation in JB6 cells. Our results demonstrate that metallic nickel nanoparticles caused higher activation of AP-1 and NF-κB, and a greater decrease of p53 transcription activity than fine particles. Western blot indicates that metallic nickel nanoparticles induced a higher level of protein expressions for R-Ras, c-myc, C-Jun, p65, and p50 in a time-dependent manner. In addition, both metallic nickel nano- and fine particles increased anchorage-independent colony formation in JB6 P+ cells in the soft agar assay. These results imply that metallic nickel fine and nanoparticles are both carcinogenetic in vitro in JB6 cells. Moreover, metallic nickel nanoparticles may exhibit higher carcinogenic potential, which suggests that precautionary measures should be taken in the use of nickel nanoparticles or its compounds in nanomedicine.http://europepmc.org/articles/PMC3972196?pdf=render |
| spellingShingle | Ruth Magaye Qi Zhou Linda Bowman Baobo Zou Guochuan Mao Jin Xu Vincent Castranova Jinshun Zhao Min Ding Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells. PLoS ONE |
| title | Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells. |
| title_full | Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells. |
| title_fullStr | Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells. |
| title_full_unstemmed | Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells. |
| title_short | Metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in JB6 cells. |
| title_sort | metallic nickel nanoparticles may exhibit higher carcinogenic potential than fine particles in jb6 cells |
| url | http://europepmc.org/articles/PMC3972196?pdf=render |
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