The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.

OBJECTIVE: To perform a meta-analysis exploring the correlation between the apparent diffusion coefficient (ADC) and tumor cellularity in patients. MATERIALS AND METHODS: We searched medical and scientific literature databases for studies discussing the correlation between the ADC and tumor cellular...

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Main Authors: Lihua Chen, Min Liu, Jing Bao, Yunbao Xia, Jiuquan Zhang, Lin Zhang, Xuequan Huang, Jian Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3823989?pdf=render
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author Lihua Chen
Lihua Chen
Min Liu
Jing Bao
Yunbao Xia
Jiuquan Zhang
Lin Zhang
Xuequan Huang
Jian Wang
author_facet Lihua Chen
Lihua Chen
Min Liu
Jing Bao
Yunbao Xia
Jiuquan Zhang
Lin Zhang
Xuequan Huang
Jian Wang
author_sort Lihua Chen
collection DOAJ
description OBJECTIVE: To perform a meta-analysis exploring the correlation between the apparent diffusion coefficient (ADC) and tumor cellularity in patients. MATERIALS AND METHODS: We searched medical and scientific literature databases for studies discussing the correlation between the ADC and tumor cellularity in patients. Only studies that were published in English or Chinese prior to November 2012 were considered for inclusion. Summary correlation coefficient (r) values were extracted from each study, and 95% confidence intervals (CIs) were calculated. Sensitivity and subgroup analyses were performed to investigate potential heterogeneity. RESULTS: Of 189 studies, 28 were included in the meta-analysis, comprising 729 patients. The pooled r for all studies was -0.57 (95% CI: -0.62, -0.52), indicating notable heterogeneity (P<0.001). After the sensitivity analysis, two studies were excluded, and the pooled r was -0.61 (95% CI: -0.66, -0.56) and was not significantly heterogeneous (P = 0.127). Regarding tumor type subgroup analysis, there were sufficient data to support a strong negative correlation between the ADC and cellularity for brain tumors. There was no notable evidence of publication bias. CONCLUSIONS: There is a strong negative correlation between the ADC and tumor cellularity in patients, particularly in the brain. However, larger, prospective studies are warranted to validate these findings in other cancer types.
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spelling doaj.art-b6f49b7300f44d5286e2619ef27ecc102022-12-21T20:37:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7900810.1371/journal.pone.0079008The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.Lihua ChenLihua ChenMin LiuJing BaoYunbao XiaJiuquan ZhangLin ZhangXuequan HuangJian WangOBJECTIVE: To perform a meta-analysis exploring the correlation between the apparent diffusion coefficient (ADC) and tumor cellularity in patients. MATERIALS AND METHODS: We searched medical and scientific literature databases for studies discussing the correlation between the ADC and tumor cellularity in patients. Only studies that were published in English or Chinese prior to November 2012 were considered for inclusion. Summary correlation coefficient (r) values were extracted from each study, and 95% confidence intervals (CIs) were calculated. Sensitivity and subgroup analyses were performed to investigate potential heterogeneity. RESULTS: Of 189 studies, 28 were included in the meta-analysis, comprising 729 patients. The pooled r for all studies was -0.57 (95% CI: -0.62, -0.52), indicating notable heterogeneity (P<0.001). After the sensitivity analysis, two studies were excluded, and the pooled r was -0.61 (95% CI: -0.66, -0.56) and was not significantly heterogeneous (P = 0.127). Regarding tumor type subgroup analysis, there were sufficient data to support a strong negative correlation between the ADC and cellularity for brain tumors. There was no notable evidence of publication bias. CONCLUSIONS: There is a strong negative correlation between the ADC and tumor cellularity in patients, particularly in the brain. However, larger, prospective studies are warranted to validate these findings in other cancer types.http://europepmc.org/articles/PMC3823989?pdf=render
spellingShingle Lihua Chen
Lihua Chen
Min Liu
Jing Bao
Yunbao Xia
Jiuquan Zhang
Lin Zhang
Xuequan Huang
Jian Wang
The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.
PLoS ONE
title The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.
title_full The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.
title_fullStr The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.
title_full_unstemmed The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.
title_short The correlation between apparent diffusion coefficient and tumor cellularity in patients: a meta-analysis.
title_sort correlation between apparent diffusion coefficient and tumor cellularity in patients a meta analysis
url http://europepmc.org/articles/PMC3823989?pdf=render
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