Ferredoxin 1, the key regulator of cuproptosis, was associated with prognosis and immune cell infiltration in clear cell renal cell carcinoma
Abstract According to a number of studies, the occurrence and progression clear cell renal cell carcinoma (ccRCC), among the most prevalent cancerous tumors of the urinary bladder, may be inextricable from metabolism and immunology. The recent discovery of cuproptosis revealed a novel cell death mec...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | MedComm – Future Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mef2.36 |
| _version_ | 1797858707106693120 |
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| author | Dian Xia Kun Liu Wen Jiao Longfei Peng Qi Liu Chang Liu Liangkuan Bi |
| author_facet | Dian Xia Kun Liu Wen Jiao Longfei Peng Qi Liu Chang Liu Liangkuan Bi |
| author_sort | Dian Xia |
| collection | DOAJ |
| description | Abstract According to a number of studies, the occurrence and progression clear cell renal cell carcinoma (ccRCC), among the most prevalent cancerous tumors of the urinary bladder, may be inextricable from metabolism and immunology. The recent discovery of cuproptosis revealed a novel cell death mechanism based on mitochondrial respiration and the tricarboxylic acid cycle, and cuproptosis is strongly linked to the metabolic process. The cuproptosis process is different from the previously revealed cell death processes such as pyroptosis, apoptosis and ferroptosis, which is expected to provide a new perspective in the study of tumor mechanism. Here we aim to explore the important role of key regulators of cuproptosis in renal cancer using a combination of bioinformatics and experimental validation. We found that Ferredoxin 1 (FDX1) was related to the infiltration of various immune cells in the tumor microenvironment and the response to immunotherapy in ccRCC. At the same time, the experiment confirmed that FDX1 was significantly lower in ccRCC, which was consistent with the previous analysis results. In conclusions, FDX1 was expected to be an important marker of immune infiltration, immunotherapy, and tumor prognosis in ccRCC. |
| first_indexed | 2024-04-09T21:17:43Z |
| format | Article |
| id | doaj.art-b6f4cd6279234097886afd5e66f5e2bd |
| institution | Directory Open Access Journal |
| issn | 2769-6456 |
| language | English |
| last_indexed | 2024-04-09T21:17:43Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Future Medicine |
| spelling | doaj.art-b6f4cd6279234097886afd5e66f5e2bd2023-03-28T06:58:31ZengWileyMedComm – Future Medicine2769-64562023-03-0121n/an/a10.1002/mef2.36Ferredoxin 1, the key regulator of cuproptosis, was associated with prognosis and immune cell infiltration in clear cell renal cell carcinomaDian Xia0Kun Liu1Wen Jiao2Longfei Peng3Qi Liu4Chang Liu5Liangkuan Bi6Department of Urology The Second Hospital of Anhui Medical University Hefei ChinaDepartment of Urology The Second Hospital of Anhui Medical University Hefei ChinaDepartment of Urology The Second Hospital of Anhui Medical University Hefei ChinaDepartment of Urology The Second Hospital of Anhui Medical University Hefei ChinaDepartment of Oncology The First Affiliated Hospital of Anhui Medical University Hefei ChinaDepartment of Urology The Second Hospital of Anhui Medical University Hefei ChinaDepartment of Urology The Second Hospital of Anhui Medical University Hefei ChinaAbstract According to a number of studies, the occurrence and progression clear cell renal cell carcinoma (ccRCC), among the most prevalent cancerous tumors of the urinary bladder, may be inextricable from metabolism and immunology. The recent discovery of cuproptosis revealed a novel cell death mechanism based on mitochondrial respiration and the tricarboxylic acid cycle, and cuproptosis is strongly linked to the metabolic process. The cuproptosis process is different from the previously revealed cell death processes such as pyroptosis, apoptosis and ferroptosis, which is expected to provide a new perspective in the study of tumor mechanism. Here we aim to explore the important role of key regulators of cuproptosis in renal cancer using a combination of bioinformatics and experimental validation. We found that Ferredoxin 1 (FDX1) was related to the infiltration of various immune cells in the tumor microenvironment and the response to immunotherapy in ccRCC. At the same time, the experiment confirmed that FDX1 was significantly lower in ccRCC, which was consistent with the previous analysis results. In conclusions, FDX1 was expected to be an important marker of immune infiltration, immunotherapy, and tumor prognosis in ccRCC.https://doi.org/10.1002/mef2.36bioinformatics engineeringclear cell renal cell carcinoma (ccRCC)cuproptosisFDX1tumor immunotherapytumor microenvironment |
| spellingShingle | Dian Xia Kun Liu Wen Jiao Longfei Peng Qi Liu Chang Liu Liangkuan Bi Ferredoxin 1, the key regulator of cuproptosis, was associated with prognosis and immune cell infiltration in clear cell renal cell carcinoma MedComm – Future Medicine bioinformatics engineering clear cell renal cell carcinoma (ccRCC) cuproptosis FDX1 tumor immunotherapy tumor microenvironment |
| title | Ferredoxin 1, the key regulator of cuproptosis, was associated with prognosis and immune cell infiltration in clear cell renal cell carcinoma |
| title_full | Ferredoxin 1, the key regulator of cuproptosis, was associated with prognosis and immune cell infiltration in clear cell renal cell carcinoma |
| title_fullStr | Ferredoxin 1, the key regulator of cuproptosis, was associated with prognosis and immune cell infiltration in clear cell renal cell carcinoma |
| title_full_unstemmed | Ferredoxin 1, the key regulator of cuproptosis, was associated with prognosis and immune cell infiltration in clear cell renal cell carcinoma |
| title_short | Ferredoxin 1, the key regulator of cuproptosis, was associated with prognosis and immune cell infiltration in clear cell renal cell carcinoma |
| title_sort | ferredoxin 1 the key regulator of cuproptosis was associated with prognosis and immune cell infiltration in clear cell renal cell carcinoma |
| topic | bioinformatics engineering clear cell renal cell carcinoma (ccRCC) cuproptosis FDX1 tumor immunotherapy tumor microenvironment |
| url | https://doi.org/10.1002/mef2.36 |
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