Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation
Abstract Most pregnancy losses worldwide are caused by implantation failure for which there is a lack of effective therapeutics. Extracellular vesicles are considered potential endogenous nanomedicines because of their unique biological functions. However, the limited supply of ULF-EVs prevents thei...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-01834-1 |
| _version_ | 1797863695276048384 |
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| author | Linjun Hong Xupeng Zang Qun Hu Yanjuan He Zhiqian Xu Yanshe Xie Ting Gu Huaqiang Yang Jie Yang Junsong Shi Enqin Zheng Sixiu Huang Zheng Xu Dewu Liu Gengyuan Cai Zicong Li Zhenfang Wu |
| author_facet | Linjun Hong Xupeng Zang Qun Hu Yanjuan He Zhiqian Xu Yanshe Xie Ting Gu Huaqiang Yang Jie Yang Junsong Shi Enqin Zheng Sixiu Huang Zheng Xu Dewu Liu Gengyuan Cai Zicong Li Zhenfang Wu |
| author_sort | Linjun Hong |
| collection | DOAJ |
| description | Abstract Most pregnancy losses worldwide are caused by implantation failure for which there is a lack of effective therapeutics. Extracellular vesicles are considered potential endogenous nanomedicines because of their unique biological functions. However, the limited supply of ULF-EVs prevents their development and application in infertility diseases such as implantation failure. In this study, pigs were used as a human biomedical model, and ULF-EVs were isolated from the uterine luminal. We comprehensively characterized the proteins enriched in ULF-EVs and revealed their biological functions in promoting embryo implantation. By exogenously supplying ULF-EVs, we demonstrated that ULF-EVs improve embryo implantation, suggesting that ULF-EVs are a potential nanomaterial to treat implantation failure. Furthermore, we identified that MEP1B is important in improving embryo implantation by promoting trophoblast cell proliferation and migration. These results indicated that ULF-EVs can be a potential nanomaterial to improve embryo implantation. |
| first_indexed | 2024-04-09T22:39:39Z |
| format | Article |
| id | doaj.art-b6f51c74d4c54d0ba6b1f6ddaa81997e |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-09T22:39:39Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-b6f51c74d4c54d0ba6b1f6ddaa81997e2023-03-22T12:16:50ZengBMCJournal of Nanobiotechnology1477-31552023-03-0121111610.1186/s12951-023-01834-1Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantationLinjun Hong0Xupeng Zang1Qun Hu2Yanjuan He3Zhiqian Xu4Yanshe Xie5Ting Gu6Huaqiang Yang7Jie Yang8Junsong Shi9Enqin Zheng10Sixiu Huang11Zheng Xu12Dewu Liu13Gengyuan Cai14Zicong Li15Zhenfang Wu16National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural UniversityAbstract Most pregnancy losses worldwide are caused by implantation failure for which there is a lack of effective therapeutics. Extracellular vesicles are considered potential endogenous nanomedicines because of their unique biological functions. However, the limited supply of ULF-EVs prevents their development and application in infertility diseases such as implantation failure. In this study, pigs were used as a human biomedical model, and ULF-EVs were isolated from the uterine luminal. We comprehensively characterized the proteins enriched in ULF-EVs and revealed their biological functions in promoting embryo implantation. By exogenously supplying ULF-EVs, we demonstrated that ULF-EVs improve embryo implantation, suggesting that ULF-EVs are a potential nanomaterial to treat implantation failure. Furthermore, we identified that MEP1B is important in improving embryo implantation by promoting trophoblast cell proliferation and migration. These results indicated that ULF-EVs can be a potential nanomaterial to improve embryo implantation.https://doi.org/10.1186/s12951-023-01834-1Uterine luminal fluidExtracellular vesiclesNanomedicine materialsImplantationMEP1B |
| spellingShingle | Linjun Hong Xupeng Zang Qun Hu Yanjuan He Zhiqian Xu Yanshe Xie Ting Gu Huaqiang Yang Jie Yang Junsong Shi Enqin Zheng Sixiu Huang Zheng Xu Dewu Liu Gengyuan Cai Zicong Li Zhenfang Wu Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation Journal of Nanobiotechnology Uterine luminal fluid Extracellular vesicles Nanomedicine materials Implantation MEP1B |
| title | Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation |
| title_full | Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation |
| title_fullStr | Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation |
| title_full_unstemmed | Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation |
| title_short | Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation |
| title_sort | uterine luminal derived extracellular vesicles potential nanomaterials to improve embryo implantation |
| topic | Uterine luminal fluid Extracellular vesicles Nanomedicine materials Implantation MEP1B |
| url | https://doi.org/10.1186/s12951-023-01834-1 |
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