Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat
Functional magnetic resonance imaging (fMRI) studies in animal models provide invaluable information regarding normal and abnormal brain function, especially when combined with complementary stimulation and recording techniques. The echo planar imaging (EPI) pulse sequence is the most common choice...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811919309292 |
| _version_ | 1819205628773531648 |
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| author | Jaakko Paasonen Hanne Laakso Tiina Pirttimäki Petteri Stenroos Raimo A. Salo Ekaterina Zhurakovskaya Lauri J. Lehto Heikki Tanila Michael Garwood Shalom Michaeli Djaudat Idiyatullin Silvia Mangia Olli Gröhn |
| author_facet | Jaakko Paasonen Hanne Laakso Tiina Pirttimäki Petteri Stenroos Raimo A. Salo Ekaterina Zhurakovskaya Lauri J. Lehto Heikki Tanila Michael Garwood Shalom Michaeli Djaudat Idiyatullin Silvia Mangia Olli Gröhn |
| author_sort | Jaakko Paasonen |
| collection | DOAJ |
| description | Functional magnetic resonance imaging (fMRI) studies in animal models provide invaluable information regarding normal and abnormal brain function, especially when combined with complementary stimulation and recording techniques. The echo planar imaging (EPI) pulse sequence is the most common choice for fMRI investigations, but it has several shortcomings. EPI is one of the loudest sequences and very prone to movement and susceptibility-induced artefacts, making it suboptimal for awake imaging. Additionally, the fast gradient-switching of EPI induces disrupting currents in simultaneous electrophysiological recordings. Therefore, we investigated whether the unique features of Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) overcome these issues at a high 9.4 T magnetic field, making it a potential alternative to EPI. MB-SWIFT had 32-dB and 20-dB lower peak and average sound pressure levels, respectively, than EPI with typical fMRI parameters. Body movements had little to no effect on MB-SWIFT images or functional connectivity analyses, whereas they severely affected EPI data. The minimal gradient steps of MB-SWIFT induced significantly lower currents in simultaneous electrophysiological recordings than EPI, and there were no electrode-induced distortions in MB-SWIFT images. An independent component analysis of the awake rat functional connectivity data obtained with MB-SWIFT resulted in near whole-brain level functional parcellation, and simultaneous electrophysiological and fMRI measurements in isoflurane-anesthetized rats indicated that MB-SWIFT signal is tightly linked to neuronal resting-state activity. Therefore, we conclude that the MB-SWIFT sequence is a robust preclinical brain mapping tool that can overcome many of the drawbacks of conventional EPI fMRI at high magnetic fields. |
| first_indexed | 2024-12-23T04:54:44Z |
| format | Article |
| id | doaj.art-b6f52f864549463d8b46662113a927db |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-23T04:54:44Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-b6f52f864549463d8b46662113a927db2022-12-21T17:59:22ZengElsevierNeuroImage1095-95722020-02-01206116338Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in ratJaakko Paasonen0Hanne Laakso1Tiina Pirttimäki2Petteri Stenroos3Raimo A. Salo4Ekaterina Zhurakovskaya5Lauri J. Lehto6Heikki Tanila7Michael Garwood8Shalom Michaeli9Djaudat Idiyatullin10Silvia Mangia11Olli Gröhn12A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USAA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Department of Psychology, University of Jyväskyla, Jyväskyla, FinlandA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USAA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USAA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USACenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USACenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USACenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USAA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Corresponding author. A.I.V. Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.Functional magnetic resonance imaging (fMRI) studies in animal models provide invaluable information regarding normal and abnormal brain function, especially when combined with complementary stimulation and recording techniques. The echo planar imaging (EPI) pulse sequence is the most common choice for fMRI investigations, but it has several shortcomings. EPI is one of the loudest sequences and very prone to movement and susceptibility-induced artefacts, making it suboptimal for awake imaging. Additionally, the fast gradient-switching of EPI induces disrupting currents in simultaneous electrophysiological recordings. Therefore, we investigated whether the unique features of Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) overcome these issues at a high 9.4 T magnetic field, making it a potential alternative to EPI. MB-SWIFT had 32-dB and 20-dB lower peak and average sound pressure levels, respectively, than EPI with typical fMRI parameters. Body movements had little to no effect on MB-SWIFT images or functional connectivity analyses, whereas they severely affected EPI data. The minimal gradient steps of MB-SWIFT induced significantly lower currents in simultaneous electrophysiological recordings than EPI, and there were no electrode-induced distortions in MB-SWIFT images. An independent component analysis of the awake rat functional connectivity data obtained with MB-SWIFT resulted in near whole-brain level functional parcellation, and simultaneous electrophysiological and fMRI measurements in isoflurane-anesthetized rats indicated that MB-SWIFT signal is tightly linked to neuronal resting-state activity. Therefore, we conclude that the MB-SWIFT sequence is a robust preclinical brain mapping tool that can overcome many of the drawbacks of conventional EPI fMRI at high magnetic fields.http://www.sciencedirect.com/science/article/pii/S1053811919309292AwakeElectroencephalographyFunctional connectivityFunctional magnetic resonance imagingRats |
| spellingShingle | Jaakko Paasonen Hanne Laakso Tiina Pirttimäki Petteri Stenroos Raimo A. Salo Ekaterina Zhurakovskaya Lauri J. Lehto Heikki Tanila Michael Garwood Shalom Michaeli Djaudat Idiyatullin Silvia Mangia Olli Gröhn Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat NeuroImage Awake Electroencephalography Functional connectivity Functional magnetic resonance imaging Rats |
| title | Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat |
| title_full | Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat |
| title_fullStr | Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat |
| title_full_unstemmed | Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat |
| title_short | Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat |
| title_sort | multi band swift enables quiet and artefact free eeg fmri and awake fmri studies in rat |
| topic | Awake Electroencephalography Functional connectivity Functional magnetic resonance imaging Rats |
| url | http://www.sciencedirect.com/science/article/pii/S1053811919309292 |
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