Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression
Plumbagin is a natural compound that is isolated from the root of the medicinal plant Plumbago zeylanica L. Based on a previous in vitro study performed by our group, which demonstrated the effectiveness of plumbagin against glioma cells, we further ascertained whether plumbagin exhibits the same ef...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-07-01
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| Series: | Journal of Pharmacological Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861315001115 |
| _version_ | 1818538140658302976 |
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| author | Mingshan Niu Wei Cai Huize Liu Yulong Chong Wenqiang Hu Shangfeng Gao Qiong Shi Xiuping Zhou Xuejiao Liu Rutong Yu |
| author_facet | Mingshan Niu Wei Cai Huize Liu Yulong Chong Wenqiang Hu Shangfeng Gao Qiong Shi Xiuping Zhou Xuejiao Liu Rutong Yu |
| author_sort | Mingshan Niu |
| collection | DOAJ |
| description | Plumbagin is a natural compound that is isolated from the root of the medicinal plant Plumbago zeylanica L. Based on a previous in vitro study performed by our group, which demonstrated the effectiveness of plumbagin against glioma cells, we further ascertained whether plumbagin exhibits the same effectiveness against glioma cell xenografts in nude mice. Our results revealed that tumor volume was reduced by 54.48% in the plumbagin-treated group compared with the controls. Furthermore, there were no obvious signs of toxicity as assessed by the organ sizes and cell morphologies of the mice that were treated with plumbagin. Immunofluorescence assays further revealed that plumbagin significantly inhibited glioma cell proliferation and induced cell apoptosis. Importantly, we also determined that the expressions of FOXM1 and its downstream target effectors, including cyclin D1 and Cdc25B, were down-regulated in the treated group, while the expressions of p21 and p27 were increased; the latter findings corroborate the results of our previous in vitro study. Taken together, these findings indicate that plumbagin may be a natural downregulator of FOXM1 with potential therapeutic effectiveness for the treatment of gliomas. |
| first_indexed | 2024-12-11T21:25:10Z |
| format | Article |
| id | doaj.art-b6f5826306a04d2d834a6ea1c86769dc |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-11T21:25:10Z |
| publishDate | 2015-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-b6f5826306a04d2d834a6ea1c86769dc2022-12-22T00:50:22ZengElsevierJournal of Pharmacological Sciences1347-86132015-07-01128313113610.1016/j.jphs.2015.06.005Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expressionMingshan Niu0Wei Cai1Huize Liu2Yulong Chong3Wenqiang Hu4Shangfeng Gao5Qiong Shi6Xiuping Zhou7Xuejiao Liu8Rutong Yu9Institute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaInstitute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaInstitute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaInstitute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaInstitute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaInstitute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaInstitute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaInstitute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaInstitute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaInstitute of Nervous System Diseases, Xuzhou Medical College, Xuzhou, Jiangsu, ChinaPlumbagin is a natural compound that is isolated from the root of the medicinal plant Plumbago zeylanica L. Based on a previous in vitro study performed by our group, which demonstrated the effectiveness of plumbagin against glioma cells, we further ascertained whether plumbagin exhibits the same effectiveness against glioma cell xenografts in nude mice. Our results revealed that tumor volume was reduced by 54.48% in the plumbagin-treated group compared with the controls. Furthermore, there were no obvious signs of toxicity as assessed by the organ sizes and cell morphologies of the mice that were treated with plumbagin. Immunofluorescence assays further revealed that plumbagin significantly inhibited glioma cell proliferation and induced cell apoptosis. Importantly, we also determined that the expressions of FOXM1 and its downstream target effectors, including cyclin D1 and Cdc25B, were down-regulated in the treated group, while the expressions of p21 and p27 were increased; the latter findings corroborate the results of our previous in vitro study. Taken together, these findings indicate that plumbagin may be a natural downregulator of FOXM1 with potential therapeutic effectiveness for the treatment of gliomas.http://www.sciencedirect.com/science/article/pii/S1347861315001115GliomaPlumbaginProliferationApoptosisFOXM1 |
| spellingShingle | Mingshan Niu Wei Cai Huize Liu Yulong Chong Wenqiang Hu Shangfeng Gao Qiong Shi Xiuping Zhou Xuejiao Liu Rutong Yu Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression Journal of Pharmacological Sciences Glioma Plumbagin Proliferation Apoptosis FOXM1 |
| title | Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression |
| title_full | Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression |
| title_fullStr | Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression |
| title_full_unstemmed | Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression |
| title_short | Plumbagin inhibits growth of gliomas in vivo via suppression of FOXM1 expression |
| title_sort | plumbagin inhibits growth of gliomas in vivo via suppression of foxm1 expression |
| topic | Glioma Plumbagin Proliferation Apoptosis FOXM1 |
| url | http://www.sciencedirect.com/science/article/pii/S1347861315001115 |
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